Mingqi ZhaoAtlanta, GA

7007710, Mar 7, 2006

Apr 21, 2003

10/421677

Jonathan Heller - San Francisco CA, US
John Stults - Redwood City CA, US
Uthara Srinivasan - Palo Alto CA, US
Luc Bousse - Los Altos CA, US
Mingqi Zhao - Cupertino CA, US

Predicant Biosciences, Inc. - South San Francisco CA

B08B 7/00
F15B 21/00

137 1501, 137807, 137827, 137833, 251368, 204601, 422100, 436180

Microfluidic devices provide substances to a mass spectrometer. The microfluidic devices include first and second surfaces, at least one microchannel formed by the surfaces, and an outlet at an edge of the surfaces which is recessed back from an adjacent portion of the edge. Hydrophilic surfaces and/or hydrophobic surfaces guide substances out of the outlet. A source of electrical potential can help move substances through the microchannel, separate substances and/or provide electrospray ionization.

7654127, Feb 2, 2010

Dec 21, 2006

11/614211

Peter Krulevitch - Pleasanton CA, US
Mingqi Zhao - San Jose CA, US
Sebastian Bohm - Los Gatos CA, US
Deon Anex - Livermore CA, US
Michael Gearhart - Fremont CA, US

Lifescan, Inc. - Milpitas CA

G01F 25/00
G01N 19/00

73 116, 738659

The present application is directed to systems and methods associated with infusion pumps, which can optionally utilize an electrokinetic driving mechanism. Infusion pumps, including electrokinetically-driven pumps, are discussed, along with schemes for controlling their operation. As well, systems and methods of detecting malfunctions in infusion pumps are discussed. Any number of malfunctions can be detected including the presence of occlusions and/or leaks. In some instances, a measurement associated with some aspect of electrokinetic phenomena (e. g. , an electrode measurement such as voltage or current) is compared with one or more sample values, the comparison allowing an indication of pump malfunction to be determined. A variety of such measurements and comparison techniques are discussed in the present disclosure.

7944366, May 17, 2011

Sep 18, 2006

11/532691

Peter Krulevitch - Pleasanton CA, US
Sebastian Bohm - Los Gatos CA, US
Mingqi Zhao - San Jose CA, US
Deon Anex - Livermore CA, US

Lifescan, Inc. - Milpitas CA

G08B 21/00
A61M 31/00
A61M 37/00
A61M 1/00
G01F 25/00
B23H 11/00
G01R 31/00

340679, 604 48, 604131, 604151, 73 116, 2042751, 324500

Systems and methods of detecting occlusions and fluid-loss conditions (e. g. , disconnects and/or leakages) in an infusion pump are discussed. For example, electrokinetic infusion pumps may develop an occlusion in the fluid flow path, which can disrupt control of fluid dispersed from the pump. As well, an infusion set disconnect can also result in a fluid-loss that can be disruptive. Such disruptions can be troublesome to systems that control the infusion pump, such as closed loop controllers. Accordingly, systems and methods described herein can be used to detect such occlusions and fluid-loss conditions during infusion pump operation. For example, a position sensor can be used to monitor fluid flow from the infusion pump, with the measurement being compared with an expected value to detect an occlusion or fluid-loss condition. Other algorithms for utilizing the position sensor are also described.

2006005, Mar 16, 2006

Sep 16, 2004

10/942612

Robert Chapman - San Mateo CA, US
Mingqi Zhao - San Jose CA, US
Jing Ni - Sunnyvale CA, US
Luc Bousse - Los Altos CA, US
John Stults - Redwood City CA, US
Say Yang - Daly City CA, US

Predicant Biosciences, Inc. - South San Francisco CA

A61K 9/14

424486000

Methods are disclosed for coating at least a portion of a hydrophobic surface, including the surfaces of plastics or other polymers. Such methods include the use of a first coating layer and/or region that interacts with the hydrophobic surface, although the formation of a chemical bond between the first coating layer and the hydrophobic surface is not required. Subsequent layers may then interact chemically or non-chemically with at least a portion of the first coating layer and/or region. Such coated surfaces may be part of a device or apparatus, including microfluidic devices.

2007006, Mar 22, 2007

Sep 18, 2006

11/532653

Arjuna Karunaratne - Fremont CA, US
Anthony Lam - Fremont CA, US
Mingqi Zhao - San Jose CA, US
Braddon Van Slyke - Arvada CO, US

LifeScan, Inc. - Milpitas CA

A61M 1/00

604152000

An infusion pump (e.g., an electrokinetic infusion pump) includes an infusion pump module and an engine that can drive a moveable piston non-mechanically. In addition, the infusion pump module includes a position detector configured for sensing a dispensing state of the infusion pump module. Such information can be utilized in a control scheme to control fluid displacement within and out of the pump. Descriptions of different types of position detectors, such as magnetic sensors (e.g., an anisotropic magnetic resistive sensor), and their implementation in detecting infusion pump fluid displacement are described.

2007009, Apr 26, 2007

Sep 18, 2006

11/532726

Peter Krulevitch - Pleasanton CA, US
Sebastian Bohm - Los Gatos CA, US
Mingqi Zhao - San Jose CA, US
Deon Anex - Livermore CA, US

LifeScan, Inc. - Milpitas CA

A61M 37/00
A61K 9/22

604131000, 604891100

Systems and methods of detecting occlusions and fluid-loss conditions (e.g., disconnects and/or leakages) in an infusion pump are discussed. For example, electrokinetic infusion pumps may develop an occlusion in the fluid flow path, which can disrupt control of fluid dispersed from the pump. As well, an infusion set disconnect can also result in a fluid-loss that can be disruptive. Such disruptions can be troublesome to systems that control the infusion pump, such as closed loop controllers. Accordingly, systems and methods described herein can be used to detect such occlusions and fluid-loss conditions during infusion pump operation. For example, a position sensor can be used to monitor fluid flow from the infusion pump, with the measurement being compared with an expected value to detect an occlusion or fluid-loss condition. Other algorithms for utilizing the position sensor are also described.

2009024, Oct 1, 2009

Mar 19, 2009

12/407173

Peter Krulevitch - Pleasanton CA, US
Robert Wilk - Sierra Village CA, US
Sean O'Connor - West Chester PA, US
Mingqi Zhao - San Jose CA, US
Zara Sieh - Pleasanton CA, US
Donna Savage - Rolling Hills Estates CA, US

LifeScan Inc. - Milpitas CA

A61M 1/00
H04Q 5/22

604500, 604151, 340 101

A medical device pump with a housing with a compartment for removably receiving a cartridge containing a therapeutic agent, a conduit configured to operatively provide a fluid flow path for therapeutic agent to exit from the cartridge, a user activated delivery button, a trigger mechanism, and a mechanical pump mechanism. The trigger mechanism, user activated delivery button and mechanical pump mechanism of the medical device pump are configured such that the trigger mechanism is activated by a user fully activating the user activated delivery button. Moreover, such full activation generates mechanical power employed by, and sufficient for, the mechanical pump mechanism to pump a predetermined volume of therapeutic agent from the cartridge and through the fluid flow path.

2010030, Dec 2, 2010

May 28, 2009

12/473953

Donna SAVAGE - Rolling Hills Estates CA, US
Peter Krulevitch - Pleasanton CA, US
Mingqi Zhao - San Jose CA, US

LifeScan, Inc. - Milpitas CA

G01N 33/487
G01N 33/50

205782, 20440301

A flexible indwelling electrochemical-based biosensor includes an elongated framework and an integrated electrochemical-based biosensor. The elongated framework is formed of an electrically conductive flexible material (e.g., a Nitinol) with a body portion, a sharp head, a distal end and a proximal end. The integrated electrochemical-based biosensor (such as an electrochemical-based glucose sensor) is integrated with the elongated framework in that the biosensor has a sensing element that is disposed over the body portion or sharp head of the elongated framework and a portion of the elongated framework is configured as an electrode component that electrically cooperates with the sensing element. The electrode component can, for example, be configured to electrically cooperate as a working electrode, counter electrode, reference electrode or combined reference/counter electrode of the sensing element. Moreover, the sharp head is disposed at the distal end of the elongated framework and the sharp head, the electrode component and at least the sensing element of the biosensor are configured for insertion into a target site (for example, a subcutaneous target site).