Gloria G Li, 5020 Confucius Plz APT 18F, New York, NY 10002

6808887, Oct 26, 2004

Jun 3, 2002

10/161025

Gloria C. Li - New York NY
Carlos Cordon-Cardo - New York NY
Honghai Ouyang - West Windsor NJ

Sloan-Kettering Institute for Cancer Research - New York NY

C12Q 168

435 6, 435 4, 435 71, 435183, 435455, 436 94

This invention provides a method of diagnosing a predisposition to cancer in a subject comprising: (a) obtaining a nucleic acid sample from the subject; and; (b) determining whether one or more of the subjects Ku70 alleles or regulatory regions to those alleles are deleted or different from the wild type so as to reduce or eliminate the subjects expression of polypeptide having tumor suppressor activity. This invention also provides a method of assessing the severity of cancer in a subject comprising: (a) obtaining a nucleic acid sample from the subject; and (b) determining whether one or more of the subjects Ku70 alleles or regulatory regions to those alleles are deleted or different from the wild type so as to reduce or eliminate the subjects expression of polypeptide having tumor suppressor activity. This invention also provides a method of assessing the severity of cancer in a subject comprising: determining the subcellular localization of Ku70 in the subject, wherein an abnormal subcellular localization of Ku70 indicates a predisposition to cancer.

7592319, Sep 22, 2009

Nov 12, 2003

10/712642

Gloria C. Li - New York NY, US
Paul W. J. J. Burgman - New York NY, US

Sloan-Kettering Institute for Cancer Research - New York NY

A01N 43/04
A01N 61/00
C12Q 1/68
C12N 15/63
C07H 21/04

514 44, 435 6, 435 911, 4353201, 435455, 514 1, 514 2, 536 231, 536 245

This invention provides a method for increasing the susceptibility of a cell to DNA-damaging agents, comprising introducing into the cell an antisense oligonucleotide that specifically hybridizes to a nucleic acid encoding a DNA dependent protein kinase subunit so as to prevent expression of the DNA dependent protein kinase subunit; wherein the antisense oligonucleotide is in an amount sufficient to increase the sensitivity of the cell to heat, chemical, or radiation-induced DNA damage; and wherein the DNA dependent protein kinase subunit is a DNA dependent protein kinase catalytic subunit, a Ku70, or a Ku80. This invention also provides a method of treating a tumor in a subject, comprising administering to the subject an antisense oligonucleotide that specifically hybridizes to a nucleic acid encoding a DNA dependent protein kinase subunit so as to prevent expression of the DNA dependent protein kinase subunit; wherein the antisense oligonucleotide is in an amount sufficient to increase the sensitivity of the tumor to heat, chemical or radiation-induced DNA damage; and wherein the DNA dependent protein kinase subunit is a DNA dependent protein kinase catalytic subunit, a Ku70, or a Ku80. This invention provides an antisense oligonucleotide that specifically hybridizes to a nucleic acid encoding a DNA dependent protein kinase subunit, wherein the DNA dependent protein kinase subunit is a DNA, dependent protein kinase catalytic subunit, Ku70, or Ku80, so as to prevent expression of the DNA dependent protein kinase subunit.

7700568, Apr 20, 2010

Dec 28, 2000

09/750410

Gloria C. Li - New York NY, US
Paul W. J. J. Burgman - Astoria NY, US

Sloan-Kettering Institute for Cancer Research - New York NY

A01N 43/04
C12Q 1/68
C12P 19/34
C12N 15/58
C07H 21/04

514 44, 435 6, 435 911, 435 9131, 435458, 514 1, 536 231, 536 245

This invention provides methods for increasing the susceptibility of cells to DNA-damaging agents, and for treating tumors in a subject, comprising introducing antisense that prevent expression of DNA dependent protein kinase catalytic subunit Ku70 or Ku80, wherein the antisense is in an amount sufficient to increase the sensitivity of the cells and tumors to heat, chemical, or radiation-induced DNA damage.

6399298, Jun 4, 2002

Jun 30, 1999

09/343634

Gloria C. Li - New York NY
Carlos Cordon-Cardo - New York NY
Honghai Ouyang - New York NY

Sloan-Kettering Institute for Cancer Research - New York NY

C12Q 168

435 6, 435 71, 435 912

This invention provides a method of diagnosing a predisposition to cancer in a subject comprising: (a) obtaining a nucleic acid sample from the subject; and; (b) determining whether one or more of the subjects Ku70 alleles or regulatory regions to those alleles are deleted or different from the wild type so as to reduce or eliminate the subjects expression of polypeptide having tumor suppressor activity. This invention also provides a method of assessing the severity of cancer in a subject comprising: (a) obtaining a nucleic acid sample from the subject; and (b) determining whether one or more of the subjects Ku70 alleles or regulatory regions to those alleles are deleted or different from the wild type so as to reduce or eliminate the subjects expression of polypeptide having tumor suppressor activity. This invention also provides a method of assessing the severity of cancer in a subject comprising: determining the subcellular localization of Ku70 in the subject, wherein an abnormal subcellular localization of Ku70 indicates a predisposition to cancer.