Xian J Zhang, 463704 Camino Real Trl, Denton, TX 76208

2019014, May 16, 2019

May 5, 2017

16/098914

- HOUSTON TX, US
Zhilin LI - Houston TX, US
Xian ZHANG - Houston TX, US

C12P 7/64
C12N 15/74
C12N 1/20
C12N 15/52
C12N 9/02

This invention describes a method of using microbial to produce fats, such as fatty acids and their derivatives, or products derived from the fatty acid synthesis cycle, such as hydroxyfatty acids, methyl ketones, and the like.

2018014, May 31, 2018

Feb 22, 2016

15/553129

- Houston TX, US
Xian ZHANG - Houston TX, US
Hui WU - Houston TX, US
Dan WANG - Houston TX, US

C12P 7/64
C12N 1/20
C12N 9/04
C12N 9/10
C12N 9/16
C12N 9/88

The present disclosure describes a genetically engineered a KASIII-independent fatty acid biosynthetic pathway that makes use of the promiscuous nature of the rest of the FAS enzymes (3-ketoacyl-ACP synthetase, 3-ketoacyl-ACP reductase, 3-hydroxyacyl ACP dehydrase, enoyl-ACP reductase) to bypass the KASIII step by providing a Co-A precursor of two or higher than two carbons (such as the four carbon butyryl-CoA) as the starting molecule. Since many CoA-based starter molecules can be supplied for the fatty acid synthesis, much more diversified products can be obtained with various carbon-chain lengths. As such, this disclosure will serve as a powerful and efficient platform to produce low to medium chain length products carrying many different functional groups.