Inventors:
James Aggen - San Francisco CA
John H. Griffin - Atherton CA
Mathai Mammen - San Mateo CA
Daniel Marquess - Half Moon Bay CA
Edmund J. Moran - San Francisco CA
David Oare - Belmont CA
Assignee:
Theravance, Inc. - South San Francisco CA
International Classification:
C07D20700
US Classification:
548537, 435 71, 435 72, 436501, 436518, 514 79, 51425212, 514315, 514317, 514361, 514419, 514482, 514506, 514588, 540450, 544358, 546190, 546191, 546192, 546244, 548400, 548469, 548473, 548477, 548486, 548530, 548517, 548518, 548519, 548520, 548521, 562400
Abstract:
Disclosed are multibinding compounds which are muscarinic receptor antagonists. The multibinding compounds of this invention containing from 2 to 10 ligands covalently attached to one or more linkers. Each ligand is, independently of each other, a muscarinic receptor antagonist or an allosteric modulator provided that at least one of said ligand is a muscarinic receptor antagonist. The multibinding compounds of this invention are useful in the treatment and prevention of diseases such as chronic obstructive pulmonary disease, chronic bronchitis, irritable bowel syndrome, urinary incontinence, and the like.