David C Alsop, 60247 Country Club Rd, Newton, MA 02459

6489766, Dec 3, 2002

Oct 10, 2000

09/673039

David C. Alsop - Newton MA

The Trustees of the University of Pennsylvania - Philadelphia PA

G01V 300

324313, 324309, 324307

A method for eliminating then on-MG component in RARE imaging that does not require a poor slice profile or discarding a substantial number of echoes (FIG. ). This method relies upon the observation that the magnetization in each component is determined by the phase at one half of the echo time before the first refocusing pulse. A ninety degree pulse applied at this time will rotate one of the components to the longitudinal axis where it will be invisible in the subsequent sequence, (b RF). If the phase of the ninety degree pulse is the same as that of the refocusing pulses, then it will be the non-MG component that is eliminated. The combination of the tailored RF train and this ninety degree pulse permits acquisition of data from the very first echo without artifact (FIGS. ).

6717405, Apr 6, 2004

Apr 12, 2002

10/121963

David Alsop - Newton MA

Beth Israel Deaconess Medical Center, Inc. - Boston MA

G01V 300

324306

The present invention relates to a method and system for conducting a magnetic resonance fluid flow study by conducting a labeling procedure and a control procedure and combining datasets from those procedures to create a dataset for the fluid flow study. An amplitude modulated magnetic field gradient and amplitude modulated RF irradiation may be applied during a labeling procedure. Likewise, amplitude modulated RF irradiation may be applied during a control procedure. An amplitude modulated magnetic field gradient may also be applied during the control procedure.

6980845, Dec 27, 2005

Apr 13, 1999

09/673049

David C. Alsop - Newton MA, US

The Trustees Of The University Of Pennsylvania - Philadelphia PA

A61B005/05

600410, 600407, 600413, 600419, 324306, 324309, 382128, 382130

This invention is a method for multi-slice CBF imaging using continuous arterial spin labeling (CASL) with an amplitude modulated control which is both highly effective at controlling for off resonance effects, and efficient at doubly inverting inflow spins, thus retaining the signal advantages of CASL versus pulsed ASL techniques.

7369888, May 6, 2008

Aug 5, 2005

11/198581

David C. Alsop - Newton MA, US

The Trustees of the University of Pennsylvania - Philadelphia PA

A61B 5/055

600419

This invention is a method for multi-slice CBF imaging using continuous arterial spin labeling (CASL) with an amplitude modulated control which is both highly effective at controlling for off resonance effects, and efficient at doubly inverting inflow spins, thus retaining the signal advantages of CASL versus pulsed ASL techniques.

7479783, Jan 20, 2009

Mar 29, 2007

11/729815

David Alsop - Newton MA, US

Beth Israel Deaconess Medical Center, Inc. - Boston MA

G01V 3/00

324307, 324309

In one aspect, a method of inducing nuclear magnetic resonance (NMR) signals from a region of an object to be imaged is provided. The method comprises applying to the region a preparation sequence configured to substantially establish a zero flip-angle pseudo steady state (PSS) for the region, applying to the region a transitioning sequence configured to transition the zero flip-angle PSS to a higher target flip-angle PSS, and applying a radio frequency (RF) pulse sequence configured to cause the region to emit detectable NMR signals.

7545142, Jun 9, 2009

Nov 1, 2006

11/591308

David Alsop - Newton MA, US

Beth Israel Deaconess Medical Center, Inc. - Boston MA

G01V 3/00

324306, 600419

In one aspect, a method for imaging fluid flow and/or perfusion using spin labeling is provided. The method comprises applying a first magnetic gradient sequence at least to a labeling region, applying a first pulsed radio frequency (RF) sequence to the labeling region to label the fluid, the first pulsed RF sequence comprising a first plurality of pulses wherein an amplitude envelope is non-zero, the first plurality of pulses each separated by a respective first plurality of intervals wherein the amplitude envelope is substantially zero, and acquiring at least one first signal emitted from an imaging region a predetermined delay after applying the first pulsed RF sequence.

7865228, Jan 4, 2011

Mar 13, 2008

12/047974

David C. Alsop - Boston MA, US

The Trustees of the University of Pennsylvania - Philadelphia PA

A61B 5/055

600419

This invention is a method for multi-slice CBF imaging using continuous arterial spin labeling (CASL) with an amplitude modulated control which is both highly effective at controlling for off resonance effects, and efficient at doubly inverting inflow spins, thus retaining the signal advantages of CASL versus pulsed ASL techniques.

8587305, Nov 19, 2013

Jan 11, 2011

13/004147

Ananth J. Madhuranthakam - Jamaica Plain MA, US
Huanzhou Yu - Sunnyvale CA, US
David C. Alsop - Newton MA, US

General Electric Company - Schenectady NY
Beth Israel Deaconess Medical Center - Boston MA

G01V 3/00
G06K 9/00

324307, 382128

An apparatus and method for separating the NMR signal contributions from a plurality of different species having different chemical shifts is disclosed. The apparatus acquires MR image data sets including a first species signal and a second species signal, generates a first species image from the acquired MR image data, and generates a second species image from the acquired MR image data. The apparatus also identifies voxels in the second species image representative of only the second species and, for voxels identified as being representative of only the second species, calculates a fraction of the second species signal appearing in the first species image. The apparatus generates a modified first species image based on the fraction of the second species signal appearing in the first species image, with the modified first species image having a different fraction of the second species as compared to the first species image.