Resumes & CV records
Resumes
Hua Xu
Location:
South Jordan, Utah
Industry:
Civil Engineering
Hua Xu
Location:
United States
Hua Xu, 54120 Moore Dr, Rockville, MD 20850
Hua Xu Phones & Addresses
120 Moore Dr, Rockville, MD 20850
Lutherville Timonium, MD
Baltimore, MD
Ypsilanti, MI
Blacklick, OH
Ann Arbor, MI
13707 Willow Tree Dr, Rockville, MD 20850
Mentions for Hua Xu
Publications & IP owners
Us Patents
Rapid Characterization Of Post-Translationally Modified Proteins From Tandem Mass Spectra
US Patent:
2007028, Dec 6, 2007
Filed:
May 29, 2007
Appl. No.:
11/754700
Inventors:
Michael Freitas - Columbus OH, US
Hua Xu - Columbus OH, US
Hua Xu - Columbus OH, US
Assignee:
THE OHIO STATE UNIVERSITY - Columbus OH
International Classification:
G06F 19/00
G01N 33/00
G01N 33/00
US Classification:
702019000, 702001000, 702020000
Abstract:
A software algorithm that matches tandem mass spectra created simultaneously and automatically to theoretical peptide sequences derived from a protein database is disclosed. The program characterizes shotgun proteomic data sets obtained from proteins (such as histones) that possess extensive posttranslational modifications that are often difficult to characterize. Data is searched against all theoretical peptides including all combinations of modifications. The program returns four scores to assess the quality of match. The employed algorithm is sensitive to mass accuracy. For high mass accuracy data, a false positive rate as low as 2% may be achieved. Monte Carlo Simulations were also used to obtain a solution to statistical models and calculate statistical scores. The program can also be used to automatically and directly identify disulfide linked proteins and peptides in tandem mass spectra without chemical reduction and/or other derivatization using a probabilistic scoring model.
Possible Relatives
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