John E Mckenzie Deceased3322 Leavesley Rd, Gilroy, CA 95020

6387116, May 14, 2002

Jun 30, 1999

09/345661

John R. McKenzie - San Carlos CA
Robert F. Zuk - Atherton CA
Axel F. Brisken - Fremont CA
Paul D. Corl - Palo Alto CA

Pharmasonics, Inc. - Sunnyvale CA

A61F 206

623 11, 604 22, 606128

A method for inhibiting hyperplasia at an anastomotic junction of a vascular fistula or vascular graft comprises exposing the anastomotic junction to vibrational energy at a mechanical index and for a time sufficient to inhibit hyperplasia. Kits are described comprising the catheter or a probe suitable for performing the methods together with instructions for use setting forth the methods. The methods and kits are particularly suitable for treating anastomotic junctions formed to provide vascular access for hemodialysis, hemofiltration, and the like. The methods and kits are also suitable for treating other vascular grafts, such as those formed during cardiac bypass graft surgery, vascular repair, and the like.

6432068, Aug 13, 2002

Mar 20, 2000

09/531027

Paul D. Corl - Palo Alto CA
Joseph Karratt - Millbrae CA
John McKenzie - San Carlos CA

Pharmasonics, Inc. - Sunnyvale CA

A61H 100

601 2, 604 22

A therapeutic ultrasound energy delivery system includes a probe having a vibrational transducer. A restraint is disposed about the transducer in order to exert a compressive pre-stress on the transducer. The restraint inhibits tensile failure of the vibrational transducer at high acoustic output.

6464680, Oct 15, 2002

Jul 29, 1998

09/126011

Axel Brisken - Fremont CA
Robert Zuk - Atherton CA
John McKenzie - San Carlos CA
Jeff Isner - Weston MA
Meno Nassi - Palo Alto CA

Pharmasonics, Inc. - Sunnyvale CA

A61M 3100

604501, 604511

A method of enhancing cellular absorption of a substance delivered into a target region of a patients body, comprising: (a) delivering the substance to the target region; and (b) directing vibrational energy to the target region, wherein the vibrational energy is of a type and in an amount sufficient to enhance absorption into cells of the target region.

6499487, Dec 31, 2002

Aug 17, 2000

09/642570

John McKenzie - San Carlos CA
Sachiko Hattori - Sunnyvale CA

Embol-X, Inc. - Mountain View CA

A61B 1900

128898, 623 131, 623 151, 623902, 604 8, 606194, 606200

Described are devices and methods for diverting emboli away from the carotid arteries in the aorta. The devices are aortic diverters that generally comprise a hollow tube with a substantially cylindrical or conical wall, which is impermeable to emboli and which has open ends that allow blood to enter one end, flow through the tube and exit the other end. Additionally, snowshoe aortic diverters, which are planar rather than cylindrical are also shown. The methods of the invention generally include the steps of providing an aortic diverter carried by an intravascular catheter, introducing the intravascular catheter into the vascular system, advancing the intravascular catheter into the aortic arch to the region of the carotid arteries, and deploying the aortic diverter.

6508775, Jan 21, 2003

Mar 20, 2001

09/813277

John McKenzie - San Carlos CA
Joseph Karratt - Millbrae CA

Pharmasonics, Inc. - Sunnyvale CA

A61M 100

601 2, 604 22, 310334, 310342, 310311, 600156, 600439, 606 41, 606 42, 606169

A therapeutic ultrasound delivery system, comprising: a catheter body; a plurality of axially spaced-apart hollow cylindrical vibrational transducers disposed along a length of the catheter body; a first spring connector wrapped around the outer surfaces of the vibrational transducers, the first spring connector exerting an inward pre-stress on the outer surfaces of the vibrational transducers; and a second connector disposed in contact with the inner surfaces of the vibrational transducers.

6524271, Feb 25, 2003

Jul 2, 2001

09/898306

Axel F. Brisken - Fremont CA
John R. McKenzie - San Carlos CA
Robert F. Zuk - Atherton CA
Menahem Nassi - Palo Alto CA
Mark W. Cowan - Fremont CA
Paul D. Corl - Palo Alto CA

Pharmasonics, Inc. - Sunnyvale CA

A61B 1720

604 22, 600466

A method of treating a target region in a body lumen, said method comprising: directing a uniform dose of ultrasonic energy from an interior of the lumen radially outward over a treatment length of the lumen, wherein the dosage of ultrasonic energy received at any one point along the length varies by no more than plus or minus 6 decibels from that received at any other point along the length.

6551268, Apr 22, 2003

Apr 14, 2000

09/550356

Alan L. Kaganov - Portola Valley CA
Jonathan D. Root - San Francisco CA
John McKenzie - San Carlos CA

Embol-X, Inc. - Mountain View CA

A61M 500

604 8, 604200, 604159

A shunt and method of use for maintaining distal blood flow during an arteriotomy procedure is disclosed. The shunt includes a first tubular member having a proximal end, a distal end, and a lumen therebetween. The proximal end has an opening in communication with the lumen, and the proximal opening is adapted to receive blood from a first region of an artery. The distal end has an opening in communication with the lumen, and the distal opening is adapted to release blood into a second region of the artery. The shunt includes a second tubular member having a proximal end, a distal end, and a lumen therebetween which either merges and communicates at its distal end with the lumen of the first tubular member, or rides separate and parallel to it. The shunt also includes a hemostatic valve attached to the proximal end of the second tubular member, the valve acting to prevent loss of blood from the lumen of the second tubular member and to permit the introduction of a medical device into the lumen of the second tubular member and into the artery. In use, the distal opening of the shunt is inserted into the second region of an artery and secured to the lumen of the artery.

6575956, Jun 10, 2003

Nov 5, 1999

09/435095

Axel F. Brisken - Fremont CA
Robert Zuk - Atherton CA
John R. McKenzie - San Carlos CA
Mark W. Cowan - Fremont CA

Pharmasonics, Inc. - Sunnyvale CA

A61M 3100

604500, 604 22

A wide beam ultrasound delivery system providing a uniform exposure field is used to enhance the uptake of injected substances and/or to enhance the transfection of DNA in the tissues of human subject, or reduce the amount of vascular intimal hyperplasia in human subjects following vascular injury.