Jonathan T Barnes, 73Tewksbury, MA

2017034, Dec 7, 2017

Jun 7, 2017

15/616498

- Cambridge MA, US
Longyan Liao - Cambridge MA, US
Jonathan Christopher Barnes - Waltham MA, US

A61K 47/69
A61K 33/24
A61K 31/4745
A61K 31/704
C08G 69/48
C07F 15/00

Described herein are platinum-based brush-arm star polymers (Pt-BASPs), or a pharmaceutical composition thereof, for delivery of platinum-based agents, such as oxaliplatin. Also provided are methods and kits involving the Pt-BASPs, or a pharmaceutical composition thereof, for treating proliferative diseases such as cancers (e.g., lung cancer, head-and-neck cancer, esophagus cancer, stomach cancer, breast cancer, pancreas cancer, colorectal cancer, liver cancer, kidney cancer, or prostate cancer) in a subject.

2016027, Sep 22, 2016

Mar 18, 2016

15/074779

- Cambridge MA, US
Jonathan Christopher Barnes - Waltham MA, US
Deborah June Choi Ehrlich - Cambridge MA, US
Yivan Jiang - Stow MA, US
Angela Xiaodi Gao - Cambridge MA, US

Massachusetts Institute of Technology - Cambridge MA

C07D 405/12
C07D 405/14
C07D 303/22

In some embodiments, macromolecules and related methods are provided. In some embodiments, an iterative growth process may be used to form a macromolecule comprising one or more repeat units comprising a functionalizable pendant group, with precise control over mass, length, backbone sequence, pendant group sequence, and/or stereochemistry, amongst other features. Macromolecules (e.g., non-natural macromolecules) form from the iterative growth process, described herein, may be used for a wide variety of applications, including the delivery of active agents.