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Lee C Makowski, ~72Brookline, MA

Lee Makowski Phones & Addresses

Brookline, MA   

5028 38Th St N, Arlington, VA 22207   

445 Adams St, Hinsdale, IL 60521   

Newton, MA   

Waltham, MA   

Tallahassee, FL   

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Lee C Makowski

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Work

Company: Northeastern university Oct 2010 to 2012 Position: Professor

Education

Degree: M.S.; Ph.D. School / High School: Massachusetts Institute of Technology 1971 to 1976 Specialities: Electrical Engineering

Industries

Biotechnology

Mentions for Lee C Makowski

Resumes

Resumes

Lee Makowski Photo 1

Professor At Northeastern University

Position:
Professor at Northeastern University
Location:
Greater Boston Area
Industry:
Biotechnology
Work:
Northeastern University since Oct 2010
Professor
Argonne National Laboratory Jun 2007 - Sep 2010
Senior Scientist
Argonne National Laboratory Aug 2000 - May 2007
Division Director; Biosciences Division
Education:
Massachusetts Institute of Technology 1971 - 1976
M.S.; Ph.D., Electrical Engineering
Brown University 1967 - 1971
B.S., Physics

Publications

Us Patents

Identification Of Molecular Targets

US Patent:
6897028, May 24, 2005
Filed:
Jul 7, 1998
Appl. No.:
09/110994
Inventors:
Lee Makowski - Arlington VA,
Diane R. Makowski - Arlington VA,
Hitesh J. Sanganee - Tallahassee FL,
Assignee:
Florida State University - Tallahassee FL
International Classification:
G01N033/53
US Classification:
435 71, 435 6, 435 5, 435 4, 435DIG 15, 435DIG 14, 536 48, 536 49, 536 50
Abstract:
Identification of the molecular targets of a drug or toxin is the first step in understanding how the drug or toxin works, an important advance in learning how to improve a drug or assess the risks due to a toxin. The primary action of a drug usually involves binding to a protein; secondary actions may express themselves in the form of side effects and in some cases may be due to binding to other proteins. Consequently, it is useful to identify all physiologically relevant sites of action of a drug or toxin. A simple method for obtaining a list of the potential targets of a drug, toxin or other biologically active substance (referred to collectively as ligands) involves a multistep process. The first step is screening a protein or peptide library to identify library members that exhibit high affinity for a particular ligand. The second step involves searching of sequence data bases for proteins that contain the sequences of the library members shown to have high affinity for the ligand.

Staged Assembly Of Nanostructures

US Patent:
2003019, Oct 23, 2003
Filed:
Feb 21, 2002
Appl. No.:
10/080608
Inventors:
Lee Makowski - Hinsdale IL,
Paul Hyman - Everett MA,
Mark Williams - Revere MA,
International Classification:
C12Q001/68
G01N033/53
B05D003/00
US Classification:
435/006000, 435/007100, 435/007500, 427/002110
Abstract:
The present invention provides methods and assembly units for the construction of nanostructures. Assembly of nanostructures proceeds by sequential, non-covalent, vectorial addition of an assembly unit to an initiator or nanostructure intermediate during an assembly cycle, a process termed “staged assembly.” Attachment of each assembly unit is mediated by specific, non-covalent binding of a single pre-determined joining element of one assembly unit to a complementary joining element on a target initiator or nanostructure intermediate. Each interaction of a joining element is designed such that the joining element does not interact with any other joining element of the assembly unit. Self-association of the assembly unit is therefore obviated: only one assembly unit can be added at a time to a target initiator or nanostructure intermediate.

Nanostructures Containing Antibody Assembly Units

US Patent:
2004001, Jan 29, 2004
Filed:
Feb 21, 2003
Appl. No.:
10/371067
Inventors:
Lee Makowski - Hinsdale IL,
Mark Williams - Revere MA,
Edward Goldberg - Newton MA,
International Classification:
C12P021/06
C07K016/00
US Classification:
435/068100, 530/387100
Abstract:
Nanostructures are made that include at least one species of assembly unit that is an antibody assembly unit in which at least one joining element, structural element or functional element is an antibody or antibody fragment. Antibody assembly units may have more than one antibody element. In addition, the antibody assembly units may contain non-antibody structural, functional or joining elements. The nanostructure is suitably prepared using a staged assembly method. In this method, a nanostructure intermediate having at least one unbound joining element is contacted with an assembly unit having a plurality of different joining elements. None of the joining elements of the assembly unit can interact with itself or with another joining element of the same assembly unit. However, one of the joining elements of the assembly unit can interact with the unbound joining element of the nanostructure intermediate, so that the assembly unit is non-covalently bound to the nanostructure intermediate to form a new nanostructure intermediate for use in subsequent cycles. Unbound assembly units are removed and the cycles is repeated for a sufficient number of cycles to form a nanostructure. The assembly units in at least one cycle are antibody assembly units.

Nanosized Biological Container And Manufacture Thereof

US Patent:
2006024, Oct 26, 2006
Filed:
Mar 20, 2006
Appl. No.:
11/384792
Inventors:
Liaohai Chen - Darien IL,
Samuel Bader - Oak Park IL,
Axel Hoffmann - Chicago IL,
Brian Kay - Chicago IL,
Lee Makowski - Hinsdale IL,
International Classification:
C12Q 1/70
C12Q 1/68
US Classification:
435006000, 435005000
Abstract:
Nanosized biological containers that are “ghosts” of viruses for which capsids are independent of their endogenous viral nucleic acid cores, provide nano-particles of uniform size, and known numbers of sites for attachments of ligands. These containers can be filled with a fluorescent, magnetic, x-ray absorbent, nucleotide components or a radioactive particle and used as nanoscale markers.

Method And System For Allowing Increased Migration Across A Lipid Bilayer

US Patent:
5284588, Feb 8, 1994
Filed:
Jan 8, 1992
Appl. No.:
7/818240
Inventors:
Lee C. Makowski - West Newton MA
Hoshang F. Batliwala - Boston MA
Assignee:
Trustees of Boston University - Boston MA
General Electric Company - Schenectady NY
International Classification:
B01D 6138
US Classification:
210638
Abstract:
A method and system are disclosed for allowing significantly increased migration of a molecule across a lipid bilayer membrane. The method includes combining an aqueous solvent medium, in which the lipid bilayer membrane and the molecule are disposed, with a solute. The aqueous solvent medium, the lipid bilayer membrane and the molecule are then exposed to a sufficient partial pressure of the solute to cause the solute to dissolve in the aqueous solvent medium, whereby a significant portion of the solute migrates to the hydrophobic fatty acyl portion of the lipid bilayer membrane. The solute thereby allows a significantly increased migration of the molecule across the lipid bilayer membrane.

Amazon

Lee Makowski Photo 3

Wild Animal Activity Book

Author:
Robin Lee Makowski
Publication Date:
2004
Binding:
Paperback
EAN Code:
0040296013988
Discover the animal kingdom with this fact-packed activity book. Dive into the world of sea creatures, charge through the wilderness with wolves and gorillas, and explore the mysteries of spiders, bats, reptiles and dinosaurs. The wild world will reveal itself to you and you venture through cool maz...
Lee Makowski Photo 4

Horace Bushnell On Christian Character Development

Author:
Lee J. Makowski
Publisher:
UPA
Publication Date:
1999-05-13
Binding:
Paperback
Pages:
210
ISBN #:
0761814019
EAN Code:
9780761814016
Horace Bushnell on Christian Character Development examines the issue of character development in the speculative works and sermons of Horace Bushnell, in relation to Orthodox Calvinist, Unitarian, and contemporary Catholic considerations of the same. The author emphasizes the practical purpose of t...
Lee Makowski Photo 5

The Saving Of Valiant Blue Heron (Buster's Adventures)

Author:
John, II Harms
Publisher:
Frederick Press
Publication Date:
2001-09-01
Binding:
Hardcover
Pages:
32
ISBN #:
193132901X
EAN Code:
9781931329019
The Saving of Valiant Blue Heron Set sail on another amazing journey with Buster, a young boy with a penchant for adventure and a love for animals and the environment. Buster's trip to a freshwater lake puts him face-to-beak with a wounded blue heron. Catching the tall bird for a trip to the wildli...
Lee Makowski Photo 6

The Big Book Of Drawing Dogs And Cats

Publisher:
LEARNING CHALLENGE
Publication Date:
2005
Binding:
Spiral-bound
ISBN #:
1592030955
EAN Code:
9781592030958
Large spiral-bound instruction book. The tabbed sections are: DOGS, CATS, DRAWING PAPER, and TRACING PAPER. Includes instructions for drawing more than 30 dogs and 30 cats!
Lee Makowski Photo 7

Wild Animals Workbook

Author:
Robin Lee Makowski
Publisher:
Kids Books
Publication Date:
2004
Binding:
Paperback
ISBN #:
1588652513
EAN Code:
9781588652515
Discover the animal kingdom with this fact packed activity workbook. Contains mazes, word searches, picture puzzles, word games, etc.
Lee Makowski Photo 8

Fish (Drawing Made Fun)

Author:
Robin Lee Makowski
Publisher:
Rourke Publishing
Publication Date:
2005-07
Binding:
Library Binding
Pages:
32
ISBN #:
159515471X
EAN Code:
9781595154712
Young readers learn the fundamentals of drawing fish. Includes introduction, hints, tips and illustrations.
Lee Makowski Photo 9

How To Draw Sea Creatures

Author:
Robin Lee Makowski
Publisher:
Kidsbooks
Publication Date:
2007
Binding:
Hardcover
ISBN #:
1588653099
EAN Code:
9781588653093
11x8 hardcover 94 pgs richly illustrated with instructions
Lee Makowski Photo 10

Cats (How To Draw (Rourke))

Author:
Robin Lee Makowski
Publisher:
Rourke Publishing
Publication Date:
2002-01
Binding:
Hardcover
ISBN #:
1589521528
EAN Code:
9781589521520
Book by Makowski, Robin Lee

Isbn (Books And Publications)

Horace Bushnell On Christian Character Development

Author:
Lee J. Makowski
ISBN #:
0761814000

Horace Bushnell On Christian Character Development

Author:
Lee J. Makowski
ISBN #:
0761814019

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