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Mark T Kieras22 Hill St, Plum Island, MA 01950

Mark Kieras Phones & Addresses

22 Hill St, Newburyport, MA 01950    978-4634086    978-4658556   

22 Hill St, Newburyport, MA 01950    978-4658556    978-4634086   

23 Purchase St, Newburyport, MA 01950   

1221 Dearborn St, Chicago, IL 60610    312-9435872   

1235 Dearborn St, Chicago, IL 60610   

1120 Balboa Ave, Burlingame, CA 94010    650-3420617   

Social networks

Mark T Kieras

Linkedin

Work

Company: Principle realty group Position: Owner

Education

Degree: Bachelor's degree School / High School: University of Illinois at Urbana-Champaign 1983 to 1987 Specialities: Psychology

Industries

Real Estate

Mentions for Mark T Kieras

Resumes

Resumes

Mark Kieras Photo 1

Owner, Principle Realty Group

Position:
Owner at Principle Realty Group
Location:
Greater Chicago Area
Industry:
Real Estate
Work:
Principle Realty Group
Owner
Education:
University of Illinois at Urbana-Champaign 1983 - 1987
Bachelor's degree, Psychology

Publications

Us Patents

Redox And Photoinitiator Systems For Priming For Improved Adherence Of Gels To Substrates

US Patent:
6387977, May 14, 2002
Filed:
Jul 14, 2000
Appl. No.:
09/616256
Inventors:
Amarpreet S. Sawhney - Lexington MA
David A. Melanson - Hudson NH
Chandrashekar P. Pathak - Lexington MA
Jeffrey A. Hubbell - San Marino CA
Luis Z. Avila - Arlington MA
Mark T. Kieras - Newburyport MA
Stephen D. Goodrich - Woburn MA
Shikha P. Barman - Lowell MA
Arthur J. Coury - Boston MA
Ronald S. Rudowsky - Sudbury MA
Douglas J. K. Weaver - Bedford MA
Marc A. Levine - Fremont CA
John C. Spiridigliozzi - Dedham MA
Thomas S. Bromander - Andover MA
Dean M. Pichon - Concord MA
George Selecman - Marblehead MA
David J. Nedder - Attleboro MA
Bradley C. Poff - White Bear Lake MN
Donald L. Elbert - Pasadena CA
Assignee:
Focal, Inc. - Lexington MA
Board of Regents, The University of Texas System - Austin TX
International Classification:
C09D 400
US Classification:
522184, 522185, 424487, 602904, 523111, 523114, 523118
Abstract:
An impoved barrier or drug delivery system which is highly adherent to the surface to which it is applied is disclosed, along with methods for making the barrier. In the preferred embodiment, tissue is stained with a photoinitiator, then the polymer solution or gel having added thereto a defined amount of the same or a different photoinitiator is applied to the tissue. On exposure to light, the resulting system polymerizes at the surface, giving excellent adherence, and also forms a gel in the rest of the applied volume. Thus a gel barrier of arbitrary thickness can be applied to a surface while maintaining high adherence at the interface. This process is referred to herein as “priming”. The polymerizable barrier materials are highly useful for sealing tissue surfaces and junctions against leaks of fluids. In another embodiment, “priming” can be used to reliably adhere preformed barriers to tissue or other surfaces, or to adhere tissue surfaces to each other.

Multiblock Biodegradable Hydrogels For Drug Delivery And Tissue Treatment

US Patent:
6410645, Jun 25, 2002
Filed:
Nov 9, 2000
Appl. No.:
09/710416
Inventors:
Chandrashekhar P. Pathak - Lexington MA
Shikha P. Barman - Bedford MA
C. Michael Philbrook - Boston MA
Amarpreet S. Sawhney - Lexington MA
Arthur J. Coury - Boston MA
Luis Z. Avila - Arlington MA
Mark T. Kieras - Burlingame CA
Assignee:
Focal, Inc. - Lexington MA
International Classification:
A61K 31765
US Classification:
525 7802, 424 7806, 424DIG 13, 424487, 523105, 524505, 525 90
Abstract:
Gel-forming macromers including at least four polymeric blocks, at least two of which are hydrophobic and at least one of which is hydrophilic, and including a crosslinkable group are provided. The macromers can be covalently crosslinked to form a gel on a tissue surface in vivo. The gels formed from the macromers have a combination of properties including thermosensitivity and lipophilicity, and are useful in a variety of medical applications including drug delivery and tissue coating.

Biodegradable Macromers For The Controlled Release Of Biologically Active Substances

US Patent:
6703037, Mar 9, 2004
Filed:
Oct 12, 2000
Appl. No.:
09/689575
Inventors:
Jeffrey A. Hubbell - Zumikon,
Mark T. Kieras - Newburyport MA
Eyal S. Ron - Lexington MA
Stephen C. Rowe - Wellesley MA
Assignee:
Pelias Technologies, Inc. - Washington DC
International Classification:
A61K 200
US Classification:
424426, 424422, 424433, 6048901, 6048911
Abstract:
A method for delivering a biologically active substance including the steps of: (a) combining said biologically active substance with a macromer; (b) forming a mixture of the combination formed in step (a); (c) polymerizing said mixture to form articles; and (d) administering said articles, or a portion thereof, to a mammal, where step (c) takes place in the absence of a polymerizable monovinyl monomer, is disclosed.

Multiblock Biodegradable Hydrogels For Drug Delivery And Tissue Treatment

US Patent:
6923986, Aug 2, 2005
Filed:
Aug 27, 2003
Appl. No.:
10/650163
Inventors:
Chandrashekhar P. Pathak - Austin TX,
Shikha P. Barman - Bedford MA,
C. Michael Philbrook - Boston MA,
Amarpreet S. Sawhney - Lexington MA,
Arthur J. Coury - Boston MA,
Luis Z. Avila - Arlington MA,
Mark T. Kieras - Burlingame CA,
Assignee:
Genzyme Corporation - Cambridge MA
International Classification:
A61K031/765
A61K009/107
C08L053/00
US Classification:
424486, 424487, 424 7806, 424DIG 13, 524504, 524505, 524916, 525 79, 525 90, 525 93, 525383, 525941
Abstract:
Gel-forming macromers including at least four polymeric blocks, at least two of which are hydrophobic and at least one of which is hydrophilic, and including a crosslinkable group are provided. The macromers can be covalently crosslinked to form a gel on a tissue surface in vivo. The gels formed from the macromers have a combination of properties including thermosensitivity and lipophilicity, and are useful in a variety of medical applications including drug delivery and tissue coating.

Multiblock Biodegradable Hydrogels For Drug Delivery And Tissue Treatment

US Patent:
7250177, Jul 31, 2007
Filed:
Jun 22, 2005
Appl. No.:
11/158565
Inventors:
Chandrashekhar P. Pathak - Phoenix AZ,
Shikha P. Barman - Bedford MA,
C. Michael Philbrook - Boston MA,
Amarpreet S. Sawhney - Lexington MA,
Arthur J. Coury - Boston MA,
Luis Z. Avila - Arlington MA,
Mark T. Kieras - Burlingame CA,
Assignee:
Genzyme Corporation - Cambridge MA
International Classification:
A61K 9/14
C08L 51/00
C08L 53/00
US Classification:
424486, 524504, 524505
Abstract:
Gel-forming macromers including at least four polymeric blocks, at least two of which are hydrophobic and at least one of which is hydrophilic, and including a crosslinkable group are provided. The macromers can be covalently crosslinked to form a gel on a tissue surface in vivo. The gels formed from the macromers have a combination of properties including thermosensitivity and lipophilicity, and are useful in a variety of medical applications including drug delivery and tissue coating.

Biodegradable Macromers For The Controlled Release Of Biologically Active Substances

US Patent:
2004019, Oct 7, 2004
Filed:
Nov 17, 2003
Appl. No.:
10/715867
Inventors:
Jeffrey Hubbell - Zumikon,
Mark Kieras - Newburyport MA,
Eyal Ron - Lexington MA,
Stephen Rowe - Wellesley MA,
International Classification:
A61F002/00
A61K009/14
US Classification:
424/423000, 424/486000
Abstract:
A method for delivering a biologically active substance including the steps of: (a) combining said biologically active substance with a macromer; (b) forming a mixture of the combination formed in step (a); (c) polymerizing said mixture to form articles; and (d) administering said articles, or a portion thereof, to a mammal, where step (c) takes place in the absence of a polymerizable monovinyl monomer, is disclosed.

Biodegradable Macromers For The Controlled Release Of Biologically Active Substances

US Patent:
6153211, Nov 28, 2000
Filed:
Jul 17, 1998
Appl. No.:
9/118242
Inventors:
Jeffrey A. Hubbell - Zumikon,
Mark T. Kieras - Newburyport MA
Eyal S. Ron - Lexington MA
Stephen C. Rowe - Wellesley MA
Assignee:
InfiMed, Inc. - Cambridge MA
International Classification:
A61F 200
A61F 1300
A61K 922
US Classification:
424426
Abstract:
A method for delivering a biologically active substance including the steps of: (a) combining said biologically active substance with a macromer; (b) forming a mixture of the combination formed in step (a); (c) polymerizing said mixture to form articles; and (d) administering said articles, or a portion thereof, to a mammal, where step (c) takes place in the absence of a polymerizable monovinyl monomer, is disclosed.

Redox And Photoinitiator Systems For Priming And Improved Adherence Of Gels To Substrates

US Patent:
6121341, Sep 19, 2000
Filed:
Oct 10, 1997
Appl. No.:
8/973077
Inventors:
Amarpreet S. Sawhney - Lexington MA
David A. Melanson - Hudson NH
Chandrashekar P. Pathak - Lexington MA
Jeffrey A. Hubbell - San Marino CA
Luis Z. Avila - Arlington MA
Mark T. Kieras - Newburyport MA
Stephen D. Goodrich - Woburn MA
Shikha P. Barman - Lowell MA
Arthur J. Coury - Boston MA
Ronald S. Rudowsky - Sudbury MA
Douglas J. K. Weaver - Bedford MA
Marc A. Levine - Fremont CA
John C. Spiridigliozzi - Dedham MA
Thomas S. Bromander - Andover MA
Dean M. Pichon - Concord MA
George Selecman - Marblehead MA
David J. Nedder - Attleboro MA
Bradley C. Poff - White Bear Lake MN
Donald L. Elbert - Pasadena CA
Assignee:
Board of Regents, The University of Texas System - Austin TX
Focal, Inc. - Lexington MA
International Classification:
C08K 100
A61F 200
US Classification:
522 84
Abstract:
An impoved barrier or drug delivery system which is highly adherent to the surface to which it is applied is disclosed, along with methods for making the barrier. In the preferred embodiment, tissue is stained with a photoinitiator, then the polymer solution or gel having added thereto a defined amount of the same or a different photoinitiator is applied to the tissue. On exposure to light, the resulting system polymerizes at the surface, giving excellent adherence, and also forms a gel in the rest of the applied volume. Thus a gel barrier of arbitrary thickness can be applied to a surface while maintaining high adherence at the interface. This process is referred to herein as "priming". the polymerizable barrier materials are highly useful for sealing tissue surfaces and junctions against leaks of fluids. In another embodiment, "priming" can be used to reliably adhere preformed barriers to tissue or other surfaces, or to adhere tissue surfaces to each other.

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