Michael Nguyen, 38San Diego, CA

2009025, Oct 8, 2009

Jan 21, 2009

12/321594

Mattias Vangbo - Fremont CA, US
William D. Nielsen - San Jose CA, US
Lullu I. Blaga - Fremont CA, US
Seth Stern - Palo Alto CA, US
Joanne Horn - Oakland CA, US
Michael Van Nguyen - San Diego CA, US
Stevan B. Jovanovich - Livermore CA, US

Microchip Biotechnologies, Inc. - Dublin CA

C12P 19/34
B01D 17/06
B01D 57/02
B01L 3/00
G01N 33/00
C12M 1/00
G01N 1/18

435 911, 204601, 204660, 204453, 422102, 422 63, 422 681, 4352872, 436177

The invention provides for devices and methods for interfacing microchips to cartridges and pneumatic manifolds. The cartridges, microchips, and pneumatic manifolds can be integrated with downstream preparation devices, such as thermal regulating devices and separation and analysis devices.

2012031, Dec 13, 2012

Aug 20, 2012

13/590051

Mattias Vangbo - Fremont CA, US
William D. Nielsen - San Jose CA, US
luliu I. Blaga - Fremont CA, US
Michael Van Nguyen - San Diego CA, US
Stevan B. Jovanovich - Livermore CA, US

IntegenX, Inc. - Pleasanton CA

G01N 27/26
G01N 21/64

435 611

The invention provides for devices and methods for interfacing microchips to cartridges and pneumatic manifolds. The cartridges, microchips, and pneumatic manifolds can be integrated with downstream preparation devices, such as thermal regulating devices and separation and analysis devices.

2013005, Feb 28, 2013

Aug 21, 2012

13/590965

Mattias Vangbo - Fremont CA, US
William D. Nielsen - San Jose CA, US
Iuliu I. Blaga - Fremont CA, US
Joanne Horn - Oakland CA, US
Michael Van Nguyen - San Diego CA, US
Stevan B. Jovanovich - Livermore CA, US

IntegenX, Inc. - Pleasanton CA

C40B 20/00

506 2

The invention provides for devices and methods for interfacing microchips to cartridges and pneumatic manifolds. The cartridges, microchips, and pneumatic manifolds can be integrated with downstream preparation devices, such as thermal regulating devices and separation and analysis devices.

2014000, Jan 2, 2014

Dec 14, 2012

13/715186

The National Institutes of Health, a component of the US Department of Health and Human Services - , US
International Business Machines Corporation - , US
Taxiarchis Botsis - Rockville MD, US
Michael D. Nguyen - Bethesda MD, US
Emily J. Woo - Rockville MD, US

International Business Machines Corporation - Armonk NY
The National Institutes of Health, a component of the US Department of Health and Human Services - Bethesda MD

G06F 17/28

704 9

Techniques include performing text mining on a set of case reports in text format to determine a set of grammar rules to be used to determine whether case reports meet a medical condition. The text mining includes performing feature selection, used to determine the set of grammar rules, that combines standardized case definitions with experience of medical officers for the medical condition and outputting the set of grammar rules. Another technique includes applying grammar rule(s) to new case report(s), the grammar rule(s) previously determined at least by performing text mining comprised of performing feature selection, used to determine the set of grammar rules, that combines standardized case definitions with experience of medical officers for the medical condition. Indication(s) are output of whether the new case report(s) meet or do not meet the medical condition. The techniques may be performed by a method, an apparatus, and a program product.

2014004, Feb 13, 2014

May 2, 2013

13/886068

Stevan Bogdan Jovanovich - Livermore CA, US
luliu I. Balga - Fremont CA, US
Allen R. Boronkay - San Jose CA, US
Joanne Horn - Oakland CA, US
Michael Van Nguyen - San Diego CA, US
William D. Nielsen - San Jose CA, US
Mattias Vangbo - Fremont CA, US

IntegenX Inc. - Pleasanton CA

C12Q 1/68
B01L 7/00

506 2, 435 612, 435 71, 436501, 506 26, 506 40, 506 38, 4352872, 422 69, 422505

The present invention discloses the integration of programmable microfluidic circuits to achieve practical applications to process biochemical and chemical reactions and to integrate these reactions. In some embodiments workflows for biochemical reactions or chemical workflows are combined. Microvalves such as programmable microfluidic circuit with Y valves and flow through valves are disclosed. In some embodiments microvalves of the present invention are used for mixing fluids, which may be part of an integrated process. These processes include mixing samples and moving reactions to an edge or reservoir for modular microfluidics, use of capture regions, and injection into analytical devices on separate devices. In some embodiments star and nested star designs, or bead capture by change of cross sectional area of a channel in a microvalve are used. Movement of samples between temperature zones are further disclosed using fixed temperature and movement of the samples by micropumps.

2022040, Dec 22, 2022

Nov 20, 2020

17/780227

- San Diego CA, US
Jim Chauvapun - San Diego CA, US
Mathias Ehrich - San Diego CA, US
Megan Monier - Corona CA, US
Michael Van Nguyen - San Diego CA, US
Dirk van den Boom - Encinitas CA, US

G01N 33/543
G01N 33/53
C12Q 1/6804
C12N 15/10

Provided are systems and methods of sample preparation and analyte detection.

2022038, Dec 1, 2022

May 25, 2022

17/824617

- San Diego CA, US
Mathias Ehrich - San Diego CA, US
Michael Van Nguyen - San Diego CA, US
Christopher Ellison - La Jolla CA, US
Jeffery William Domenighini - Encinitas CA, US
Dylann Duncan Ceriani - San Diego CA, US
Kristopher Scott Buchanan - Fort Collins CO, US
Michael Gordon Smith - Fort Collins CO, US

C12N 15/10
C12Q 1/6806

Provided herein are devices and methods for extracting blood plasma from ultra-low volumes of blood. In some cases, the devices and methods use positive pressure to force a blood sample through a filter or a membrane. In some cases, the devices and methods use centrifugation to force a blood sample through a filter or a membrane. The devices and methods disclosed herein are suitable for the preparation of high-quality samples containing cell-free nucleic acids.

2023006, Mar 2, 2023

Jan 28, 2021

17/795853

- San Diego CA, US
Kapil MAHAKALKAR - San Diego CA, US
Yi ZHANG - San Diego CA, US
Andrew Boyd MACCONNELL - San Diego CA, US
Joseph Franklin ROKICKI - San Diego CA, US
Michael VAN NGUYEN - San Diego CA, US

C12N 15/10
B01L 3/00

This application provides a bead with a covalently attached chemical compound and a covalently attached DNA barcode and methods for using such beads. The bead has many substantially identical copies of the chemical compound and many substantially identical copies of the DNA barcode. The compound consists of one or more chemical monomers, where the DNA barcode takes the form of barcode modules, where each module corresponds to and allows identification of a corresponding chemical monomer. The nucleic acid barcode can have a concatenated structure or an orthogonal structure. Provided are a method for sequencing the bead-bound nucleic acid barcode, for cleaving the compound from the bead, and for assessing biological activity of the released compound.