Susumu M Tonegawa, 85101 Chestnut Hill Rd, Boston, MA 02467

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101 Chestnut Hill Rd, Chestnut Hill, MA 02467 617-7396993

Boston, MA

Waterville Valley, NH

Newton, MA

Sibley, IL

Boston Clg, MA

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Susumu Tonegawa videos

Youtube

Nobel Laureate Lecture: Susumu Tonegawa, '68 Phd

Duration:

1h 1m

Category:

Science & Technology

Uploaded:

07 Jan, 2011

Description:

UCSD Biology 50th Anniversary Special Event Nobel Laureate Lecture: Susumu Tonegawa, '68 PhD From Molecular Biology to Immunology and Neuroscience: A Journey of a Lifetime Susumu Tonegawa's extraordinary and prolific scientific career may be encapsulated in threes: three continents, three discipline...

Alberto Anilu Rafael Susumu Tonegawa

Duration:

1m 59s

Category:

Entertainment

Uploaded:

06 Jul, 2009

Description:

Rafael, Alberto y Anilu hablando del premio nobel de medicina 1987 Susumu Tonegawa IMEVISION

Frontiers In Bioscience: Learning And Memory

Duration:

2m 37s

Category:

Education

Uploaded:

15 Jul, 2009

Description:

Prominent scholars from around the world attended at the conference included Nobel Laureate Professor Susumu Tonegawa, and renowned academicians Professor David Anderson, from the California Institute of Technology; Professor Duan Shumin and Professor Guo Aike, of the Chinese Academy of Sciences; Pr...

Advice From A Nobel Laureate

Duration:

4m 24s

Category:

Science & Technology

Uploaded:

12 Oct, 2007

Description:

Interviewee: Susumu Tonegawa Producer: Sandy Chase

Controlling The Brain With Light To Reactivate Lost Memories | Susumu Tonegawa

Duration:

5m 14s

Description:

We can now use optogenetics to manipulate memories in a mouse's brain implanting a false memory, or curing depression by...

A Conversation With Susumu Tonegawa

Duration:

1h 8m 3s

Description:

Professor of Biology and Neuroscience Susumu Tonegawa discusses being a molecular biologist by training, but earning a Nobel...

Iconic Voices From Mit Featuring Professor Susumu Tonegawa

Duration:

1h 28m 50s

Description:

Throughout the history of mankind, human beings have been fascinated by memory how do we form, store, and recall...

Susumu Tonegawa, Nobel Prize In Medicine 1987: How I Define Creativity...

Duration:

1m 20s

Description:

Listen to Medicine Laureate Susumu Tonegawa's humble and inspiring reply to this question that he received at the Nobel Prize...

In the News

News

'Lost' Memories Wiped Out By Alzheimer's Could Be Revived

Date:

Mar 19, 2016

Category:

Health

Source:

Times of Malta

led to optogenetics offers the tantalising idea that tagged memories can be reactivated by light. The fascinating technique developed by the Nobel Laureate Susumu Tonegawa and his team at MIT cannot be used in humans, but it indicates that forgetfulness in AD mice may also be an access problem.

'Lost' Memories In Alzheimer Sufferers May Be Recoverable, Says Study

Date:

Mar 19, 2016

Category:

Health

Source:

Good News Network

As humans and mice tend to have a common principle in terms of memory, our findings suggest that Alzheimers disease patients, at least in their early stages, may also keep memories in their brains, which means there may be a possibility of a cure, Susumu Tonegawa, the Picower Professor of Biology

Light Therapy Shows Promise In Activating Memories Lost Due To Alzheimer's

Date:

Mar 19, 2016

Category:

Health

Source:

FOX 11 Los Angeles

ems to be gone, it is still there. Its a matter of how to retrieve it, senior study author Susumu Tonegawa, the Picower Professor of Biology and Neuroscience and director of the RIKEN-MIT Center for Neural Circuit Genetics at the Picower Institute for Learning and Memory, said in a news release.

'Lost' Alzheimer's Memories Can Be Found

Date:

Mar 17, 2016

Category:

Health

Source:

Laboratory Equipment

ncept. That is, even if a memory seems to be gone, it is still there. Its a matter of how to retrieve it, says Susumu Tonegawa, the Picower Professor of Biology and Neuroscience and director of the RIKEN-MIT Center for Neural Circuit Genetics at the Picower Institute for Learning and Memory.

Breakthrough Discovery May Lead To Re-Booting Memories For Alzheimer Patients

Date:

Mar 17, 2016

Category:

Health

Source:

BABW News

emory seems to be gone, it is still there. Its a matter of how to retrieve it, says Susumu Tonegawa, the Picower Professor of Biology and Neuroscience and director of the RIKEN-MIT Center for Neural Circuit Genetics at the Picower Institute for Learning and Memory, in the statement from MIT.

Memories 'Lost' To Alzheimer's Are Recoverable

Date:

Mar 17, 2016

Category:

Health

Source:

Times of India

"The important point is, this a proof of concept. That is, even if a memory seems to be gone, it is still there. It's a matter of how to retrieve it," says senior author Susumu Tonegawa from RIKEN-MIT Center for Neural Circuit Genetics.

Nerve Cell Stimulation 'May Recall Memories' In Alzheimer's Patients

Date:

Mar 16, 2016

Category:

Health

Source:

The Guardian

Lead scientist Prof Susumu Tonegawa, from the Picower institute for learning and memory at the Massachusetts Institute of Technology (MIT) in the US, said: The important point is, this a proof of concept. That is, even if a memory seems to be gone, it is still there. Its a matter of how to retriev

tantalising idea that tagged memories can be reactivated by light. The fascinating technique developed by the Nobel laureate Susumu Tonegawa and his team at MIT cannot be used in humans, but it indicates that forgetfulness in [mice with Alzheimers symptoms] may also be an access problem.

Let There Be Light: Lost Memories Restored To Alzheimer's Mice

Date:

Mar 16, 2016

Category:

Health

Source:

CNET

Led by Susumu Tonegawa at the RIKEN-MIT Center for Neural Circuit Genetics, the team has successfully used a technique called optogenetics to restore memories to lab mice with Alzheimer's disease. This indicates that Alzheimer's disease affects memory retrieval, rather than formation and storage. It

Publications & IP owners

Wikipedia

Jerry Adams

…Their research, following that by Susumu Tonegawa, also led to the discovery that antibody genes encode as bits and pieces, that can recombine in a myriad of ways to help fight infection; they also confirmed earlier work by Shen-Ong & Cole, Leder, Hood, Croce, and Hayward that genetic mutati...

Susumu Tegawa

Susumu Tonegawa ( Tonegawa Susumu, born September 6, 1939) is a Japanese scientist who won the Nobel Prize for Physiology or Medicine in 1987 for ...

Us Patents

Identifying Calcineurin Activators For Treatment Of Schizophrenia

US Patent:

7935500, May 3, 2011

Filed:

Mar 26, 2003

Appl. No.:

10/400348

Inventors:

David J. Gerber - Somerville MA, US
Maria Karayiorgou - Riverdale NY, US
Tsuyoshi Miyakawa - Aichi, JP
Susumu Tonegawa - Chestnut Hill MA, US

Assignee:

Massachusetts Institute of Technology - Cambridge MA
Rockefeller University - New York NY

International Classification:

C12Q 1/34
C12Q 1/68
C12Q 1/02
G01N 33/53
G01N 33/15

US Classification:

435 18, 435 6, 435 71, 435 29, 800 3

Abstract:

The present invention provides targets, methods, and reagents for the diagnosis and treatment of schizophrenia and related conditions. The invention provides methods for the diagnosis of schizophrenia and susceptibility to schizophrenia by detection of polymorphisms, mutations, variations, alterations in expression, etc. , in calcineurin genes or calcineurin interacting genes, or polymorphisms linked to such genes. The invention provides oligonucleotides, arrays, and antibodies for detection of polymorphisms and variants. The invention provides transgenic mice having alterations in such genes. The invention also provides methods of treating schizophrenia by administering compounds that target these genes. The invention further provides screening methods for identifying such compounds and compounds obtained by performing the screens.

Egr Genes As Targets For The Diagnosis And Treatment Of Schizophrenia

US Patent:

2005015, Jul 21, 2005

Filed:

Jun 30, 2004

Appl. No.:

10/881185

Inventors:

David Gerber - Somerville MA, US
Joseph Gogos - Riverdale NY, US
Diana Hall - Lausanne, CH
Maria Karayiorgou - Riverdale NY, US
Susumu Tonegawa - Chestnut Hill MA, US

International Classification:

C12Q001/68

US Classification:

435006000

Abstract:

The present invention provides targets, methods, and reagents for the diagnosis and treatment of schizophrenia and related conditions. The invention provides methods for the diagnosis of schizophrenia and susceptibility to schizophrenia by detection of polymorphisms, mutations, variations, alterations in expression, etc., in genes encoding an EGR molecule or an EGR interacting molecule, or polymorphisms linked to such genes. The invention provides oligonucleotides, arrays, and antibodies for detection of polymorphisms and variants. The invention provides transgenic mice having alterations in such genes. The invention also provides methods of treating schizophrenia by administering compounds that target these genes. The invention further provides screening methods for identifying such compounds and compounds obtained by perfoming the screens.

Pak Modulators

US Patent:

2010024, Sep 30, 2010

Filed:

Nov 9, 2007

Appl. No.:

12/514288

Inventors:

Susumu Tonegawa - Chestnut Hill MA, US
Mansuo L. Hayashi - Winchester MA, US
Bridget Dolan - Boston MA, US

Assignee:

MASSACHUSETTS INSTITUTE OF TECHNOLOGY - Boston MA

International Classification:

A61K 39/395
C12Q 1/48
A61K 38/17
A61K 48/00
A61K 31/122
A61K 31/415
A61P 25/00
A61P 15/00
G01N 33/00
G01N 33/573
A01K 67/027

US Classification:

4241721, 435 15, 514 177, 514 44 A, 514680, 514406, 800 3, 435 74, 800 18

Abstract:

The present invention provides methods for treating fragile X syndrome and/or other neurodevelopmental disorders by administering p21-activated kinase (PAK) modulators to a patient suffering from, susceptible to, and/or exhibiting one or more symptoms of FXS and/or other neurodevelopmental disorders. The present invention provides PAK modulators and pharmaceutical compositions comprising PAK modulators. The present invention further provides methods for identifying and/or characterizing PAK modulators.

Targets, Methods, And Reagents For Diagnosis And Treatment Of Schizophrenia

US Patent:

2011017, Jul 14, 2011

Filed:

Mar 16, 2011

Appl. No.:

13/049502

Inventors:

David J. Gerber - Somerville MA, US
Maria Karayiorgou - New York NY, US
Tsuyoshi Miyakawa - Kyoto, JP
Susumu Tonegawa - Chestnut Hill MA, US

Assignee:

MASSACHUSETTS INSTITUTE OF TECHNOLOGY - Cambridge MA
ROCKEFELLER UNIVERSITY - New York NY

International Classification:

A61K 38/02
A61P 25/18
C12Q 1/68

US Classification:

514 175, 435 611

Abstract:

The present invention provides targets, methods, and reagents for the diagnosis and treatment of schizophrenia and related conditions. The invention provides methods for the diagnosis of schizophrenia and susceptibility to schizophrenia by detection of polymorphisms, mutations, variations, alterations in expression, etc., in calcineurin genes or calcineurin interacting genes, or polymorphisms linked to such genes. The invention provides oligonucleotides, arrays, and antibodies for detection of polymorphisms and variants. The invention provides transgenic mice having alterations in such genes. The invention also provides methods of treating schizophrenia by administering compounds that target these genes. The invention further provides screening methods for identifying such compounds and compounds obtained by performing the screens.

Targets, Methods, And Reagents For Diagnosis And Treatment Of Schizophrenia

US Patent:

2011028, Nov 24, 2011

Filed:

Aug 5, 2011

Appl. No.:

13/204245

Inventors:

David J. Gerber - Somerville MA, US
Maria Karayiorgou - New York NY, US
Tsuyoshi Miyakawa - Kyoto, JP
Susumu Tonegawa - Chestnut Hill MA, US

Assignee:

ROCKEFELLER UNIVERSITY - New York NY
MASSACHUSETTS INSTITUTE OF TECHNOLOGY - Cambridge MA

International Classification:

A61K 38/02
A61K 49/00
A61P 25/18
C12Q 1/68

US Classification:

514 175, 435 612, 800 3, 435 611

Abstract:

The present invention provides targets, methods, and reagents for the diagnosis and treatment of schizophrenia and related conditions. The invention provides methods for the diagnosis of schizophrenia and susceptibility to schizophrenia by detection of polymorphisms, mutations, variations, alterations in expression, etc., in calcineurin genes or calcineurin interacting genes, or polymorphisms linked to such genes. The invention provides oligonucleotides, arrays, and antibodies for detection of polymorphisms and variants. The invention provides transgenic mice having alterations in such genes. The invention also provides methods of treating schizophrenia by administering compounds that target these genes. The invention further provides screening methods for identifying such compounds and compounds obtained by performing the screens.

Small Molecule Pak Inhibitors

US Patent:

2011029, Dec 1, 2011

Filed:

Nov 9, 2007

Appl. No.:

12/514290

Inventors:

Susumu Tonegawa - Chestnut Hill MA, US
Mansuo L. Hayashi - Winchester MA, US
Mazen Karaman - San Diego CA, US
Patrick P. Zarrinkar - San Diego CA, US
Daniel K. Treiber - San Diego CA, US

Assignee:

Massachusetts Institute of Technology - Boston MA

International Classification:

A61K 31/553
A61K 31/496
A61P 25/00
A61K 31/4196
A61K 31/5377
A61K 31/404
A61K 31/454
A61K 31/4706

US Classification:

51421108, 514326, 51425406, 514313, 514383, 5142352, 514414, 51425219

Abstract:

The present invention provides methods for treating fragile X syndrome and/or other neurodevelopmental disorders by administering small molecule p21-activated kinase (PAK) inhibitors to a patient suffering from, susceptible to, and/or exhibiting one or more symptoms of FXS and/or other neurodevelopmental disorders. The present invention provides specific small molecule PAK inhibitors and pharmaceutical compositions comprising small molecule PAK inhibitors.

Heterodimeric T Lymphocyte Receptor

US Patent:

4970296, Nov 13, 1990

Filed:

Jul 27, 1989

Appl. No.:

7/385897

Inventors:

Haruo Saito - Arlington MA
David M. Kranz - Somerville MA
Herman N. Eisen - Waban MA
Susumu Tonegawa - Chestnut Hill MA

Assignee:

Massachusetts Institute of Technology - Cambridge MA
Board of Trustees of Leland Stanford Jr. University - Stanford CA

International Classification:

C07K 1300
C07K 1500
C12N 1500

US Classification:

530323

Abstract:

Disclosed is a heterodimeric T lymphocyte receptor comprising an alpha and a beta subunit. Each subunit consists of a signal peptide, variable, joining, constant, transmembrane, and cytoplasmic regions. The two subunits are connected by a disulfide bond between cysteine residues located between the constant and transmembrane region. The structure, amino acid, and nucleotide sequence of the lymphocyte receptor were determined using CDNA clones derived from a functional murine cytotoxic T lymphocyte clone. The genes corresponding to these cDNA are expressed and rearranged specifically in T cells and have significant sequence homologies to immunoglobulin V and C genes. Both the T cell receptor protein and its subunits may be produced from the cDNA clones. The protein molecules may be further used for the production of T-cell clone specific antibodies.

Heterodimeric T Lymphocyte Receptor

US Patent:

4873190, Oct 10, 1989

Filed:

Oct 31, 1984

Appl. No.:

6/666988

Inventors:

Haruo Saito - Arlington MA
David M. Kranz - Somerville MA
Herman N. Eisen - Waban MA
Susumu Tonegawa - Chestnut Hill MA

Assignee:

Massachusetts Institute of Technology - Cambridge MA

International Classification:

C12P 2100
C12N 1500
C07K 1300
C07H 1512

US Classification:

4351723

Abstract:

Disclosed is a heterodimeric T lymphocyte receptor comprising an alpha and a beta subunit. Each subunit consists of a signal peptide, variable, joining, constant, transmembrane, and cytoplasmic regions. The two subunits are connected by a disulfide bond between cysteine residues located between the constant and transmembrane region. The structure, amino acid, and nucleotide sequence of the lymphocyte receptor were determined using cDNA clones derived from a functional murine cytotoxic T lymphocyte clone. The genes corresponding to these cDNA are expressed and rearranged specifically in T cells and have significant sequence homologies to immunoglobulin V and C genes. Both the T cell receptor protein and its subunits may be produced from the cDNA clones. The protein molecules may be further used for the production of T-cell clone specific antibodies.

Possible Relatives

Susumu Watanabe Susumu S Yamada Susumu Kato Susumu Kobayashi Susumu Ohkawa Susumu Koyama

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