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Thomas A Stoklasek, 4424 Butternut Dr, Unionville, CT 06085

Known as:
Thomas A Stoklesek Tom A Stoklasek
Related to:
Miroslav Stoklasek 77

Thomas Stoklasek Phones & Addresses

24 Butternut Dr, Unionville, CT 06085   

Seattle, WA   

Newington, CT   

Bristol, CT   

2920 Eastlake Ave E APT 301, Seattle, WA 98102    203-3683636   

Work

Position: Service Occupations

Education

Degree: High school graduate or higher
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Mentions for Thomas A Stoklasek

Publications & IP owners

Us Patents

Compositions And Methods For Immunomodulation In An Organism

US Patent:
2006026, Nov 23, 2006
Filed:
May 17, 2006
Appl. No.:
11/435497
Inventors:
Leo Lefrancois - West Hartford CT, US
Thomas Stoklasek - Bristol CT, US
Assignee:
University of Connecticut - Farmington CT
International Classification:
C07K 14/54
C07K 16/46
C07H 21/04
C12P 21/04
US Classification:
435069520, 435320100, 435325000, 530351000, 530391100, 536023530
Abstract:
The present invention relates to a therapeutic polypeptide and methods for its creation and use for modulating an immune response in a host organism in need thereof. In particular, the invention relates to the administration to an organism in need thereof, of an effective amount of a pre-coupled polypeptide complex comprising a lymphokine polypeptide portion, for example IL-15 (SEQ ID NO: 5, 6), IL-2 (SEQ ID NO: 10, 12) or combinations of both, and an interleukin receptor polypeptide portion, for example IL-15Ra (SEQ ID NO: 7, 8), IL-2Ra (SEQ ID NO: 9, 11) or combinations of both, for augmenting the immune system in, for example, cancer, SCID, AIDS, or vaccination; or inhibiting the immune system in, for example, rheumatoid arthritis, or Lupus. The therapeutic complex of the invention surprisingly demonstrates increased half-life, and efficacy in vivo.

Compositions And Methods For Immunomodulation In An Organism

US Patent:
2012017, Jul 12, 2012
Filed:
Feb 8, 2012
Appl. No.:
13/368605
Inventors:
Leo Lefrancois - West Hartford CT, US
Thomas A. Stoklasek - Bristol CT, US
Assignee:
UNIVERSITY OF CONNECTICUT - Farmington CT
International Classification:
A61K 38/20
A61P 7/00
A61P 37/04
A61P 31/00
A61P 35/00
A61P 35/02
US Classification:
424 852
Abstract:
The present invention relates to a therapeutic polypeptide and methods for its creation and use for modulating an immune response in a host organism in need thereof. In particular, the invention relates to the administration to an organism in need thereof, of an effective amount of a pre-coupled polypeptide complex comprising a lymphokine polypeptide portion, for example IL-15 (SEQ ID NO: 5, 6), IL-2 (SEQ ID NO: 10, 12) or combinations of both, and an interleukin receptor polypeptide portion, for example IL-15Ra (SEQ ID NO: 7, 8), IL-2Ra (SEQ ID NO: 9, 11) or combinations of both, for augmenting the immune system in, for example, cancer, SCID, AIDS, or vaccination; or inhibiting the immune system in, for example, rheumatoid arthritis, or Lupus. The therapeutic complex of the invention surprisingly demonstrates increased half-life, and efficacy in vivo.

Compositions And Methods For Immunomodulation In An Organism

US Patent:
2020029, Sep 17, 2020
Filed:
Sep 19, 2019
Appl. No.:
16/575627
Inventors:
- Farmington CT, US
Thomas A. Stoklasek - Bristol CT, US
International Classification:
C07K 14/715
A61K 38/17
A61K 38/20
C07K 14/55
C07K 14/54
C07K 1/02
C07K 16/00
Abstract:
The present invention relates to a therapeutic polypeptide and methods for its creation and use for modulating an immune response in a host organism in need thereof. In particular, the invention relates to the administration to an organism in need thereof, of an effective amount of a pre-coupled polypeptide complex comprising a lymphokine polypeptide portion, for example IL-15 (SEQ ID NO: 5, 6), IL-2 (SEQ ID NO: 10, 12) or combinations of both, and an interleukin receptor polypeptide portion, for example IL-15Ra (SEQ ID NO: 7, 8), IL-2Ra (SEQ ID NO: 9, 11) or combinations of both, for augmenting the immune system in, for example, cancer, SCID, AIDS, or vaccination; or inhibiting the immune system in, for example, rheumatoid arthritis, or Lupus. The therapeutic complex of the invention surprisingly demonstrates increased half-life, and efficacy in vivo.

Compositions And Methods For Immunomodulation In An Organism

US Patent:
2018029, Oct 18, 2018
Filed:
Apr 5, 2018
Appl. No.:
15/946402
Inventors:
- Farmington CT, US
Thomas A. Stoklasek - Bristol CT, US
International Classification:
C07K 14/715
C07K 14/55
A61K 38/17
A61K 38/20
C07K 1/02
C07K 14/54
C07K 16/00
A61K 38/00
Abstract:
The present invention relates to a therapeutic polypeptide and methods for its creation and use for modulating an immune response in a host organism in need thereof. In particular, the invention relates to the administration to an organism in need thereof, of an effective amount of a pre-coupled polypeptide complex comprising a lymphokine polypeptide portion, for example IL-15 (SEQ ID NO: 5, 6), IL-2 (SEQ ID NO: 10, 12) or combinations of both, and an interleukin receptor polypeptide portion, for example IL-15Ra (SEQ ID NO: 7, 8), IL-2Ra (SEQ ID NO: 9, 11) or combinations of both, for augmenting the immune system in, for example, cancer, SCID, AIDS, or vaccination; or inhibiting the immune system in, for example, rheumatoid arthritis, or Lupus. The therapeutic complex of the invention surprisingly demonstrates increased half-life, and efficacy in vivo.

Compositions And Methods For Immunomodulation In An Organism

US Patent:
2016034, Dec 1, 2016
Filed:
May 17, 2016
Appl. No.:
15/156618
Inventors:
Thomas A. Stoklasek - Bristol CT, US
Assignee:
UNIVERSITY OF CONNECTICUT - FARMINGTON CT
International Classification:
C07K 14/715
C07K 14/54
Abstract:
The present invention relates to a therapeutic polypeptide and methods for its creation and use for modulating an immune response in a host organism in need thereof. In particular, the invention relates to the administration to an organism in need thereof, of an effective amount of a pre-coupled polypeptide complex comprising a lymphokine polypeptide portion, for example IL-15 (SEQ ID NO: 5, 6), IL-2 (SEQ ID NO: 10, 12) or combinations of both, and an interleukin receptor polypeptide portion, for example IL-15Ra (SEQ ID NO: 7, 8), IL-2Ra (SEQ ID NO: 9, 11) or combinations of both, for augmenting the immune system in, for example, cancer, SCID, AIDS, or vaccination; or inhibiting the immune system in, for example, rheumatoid arthritis, or Lupus. The therapeutic complex of the invention surprisingly demonstrates increased half-life, and efficacy in vivo.

Compositions And Methods For Immunomodulation In An Organism

US Patent:
2016033, Nov 17, 2016
Filed:
May 18, 2016
Appl. No.:
15/158210
Inventors:
Leo Lefrancois - West Hartford CT, US
Thomas A. Stoklasek - Bristol CT, US
Assignee:
UNIVERSITY OF CONNECTICUT - FARMINGTON CT
International Classification:
C07K 14/54
C07K 14/715
Abstract:
The present invention relates to a therapeutic polypeptide and methods for its creation and use for modulating an immune response in a host organism in need thereof. In particular, the invention relates to the administration to an organism in need thereof, of an effective amount of a pre-coupled polypeptide complex comprising a lymphokine polypeptide portion, for example IL-15 (SEQ ID NO: 5, 6), IL-2 (SEQ ID NO: 10, 12)or combinations of both, and an interleukin receptor polypeptide portion, for example IL-15Ra (SEQ ID NO: 7, 8), IL-2Ra (SEQ ID NO: 9, 11) or combinations of both, for augmenting the immune system in, for example, cancer, SCID, AIDS, or vaccination; or inhibiting the immune system in, for example, rheumatoid arthritis, or Lupus. The therapeutic complex of the invention surprisingly demonstrates increased half-life, and efficacy in vivo.

Compositions And Methods For Immunomodulation In An Organism

US Patent:
2015013, May 21, 2015
Filed:
Dec 11, 2014
Appl. No.:
14/567382
Inventors:
- Farmington CT, US
Thomas A. Stoklasek - Bristol CT, US
Assignee:
UNIVERSITY OF CONNECTICUT - Farmington CT
International Classification:
C07K 14/54
C07K 1/02
C07K 14/715
C07K 16/00
US Classification:
424 852, 530351, 536 234, 435325, 435455
Abstract:
The present invention relates to a therapeutic polypeptide and methods for its creation and use for modulating an immune response in a host organism in need thereof. In particular, the invention relates to the administration to an organism in need thereof, of an effective amount of a pre-coupled polypeptide complex comprising a lymphokine polypeptide portion, for example IL-15 (SEQ ID NO: 5, 6), IL-2 (SEQ ID NO: 10, 12) or combinations of both, and an interleukin receptor polypeptide portion, for example IL-15Ra (SEQ ID NO: 7, 8), IL-2Ra (SEQ ID NO: 9, 11) or combinations of both, for augmenting the immune system in, for example, cancer, SCID, AIDS, or vaccination; or inhibiting the immune system in, for example, rheumatoid arthritis, or Lupus. The therapeutic complex of the invention surprisingly demonstrates increased half-life, and efficacy in vivo.

Compositions And Methods For Immunomodulation In An Organism

US Patent:
2015009, Apr 2, 2015
Filed:
Dec 11, 2014
Appl. No.:
14/567317
Inventors:
- Farmington CT, US
Thomas A. Stoklasek - Bristol CT, US
Assignee:
UNIVERSITY OF CONNECTICUT - Farmington CT
International Classification:
C07K 14/54
C07K 14/715
US Classification:
424 852, 530351, 536 234, 435375, 4352523, 43525233, 435348, 4352542, 435325
Abstract:
The present invention relates to a therapeutic polypeptide and methods for its creation and use for modulating an immune response in a host organism in need thereof. In particular, the invention relates to the administration to an organism in need thereof, of an effective amount of a pre-coupled polypeptide complex comprising a lymphokine polypeptide portion, for example IL-15 (SEQ ID NO: 5, 6), IL-2 (SEQ ID NO: 10, 12) or combinations of both, and an interleukin receptor polypeptide portion, for example IL-15Ra (SEQ ID NO: 7, 8), IL-2Ra (SEQ ID NO: 9, 11) or combinations of both, for augmenting the immune system in, for example, cancer, SCID, AIDS, or vaccination; or inhibiting the immune system in, for example, rheumatoid arthritis, or Lupus. The therapeutic complex of the invention surprisingly demonstrates increased half-life, and efficacy in vivo.

Possible Relatives

Thomas D Johnson  Thomas Stamps  Thomas W Stancil  Thomas P Stanczak  Thomas K Standen  Thomas F Stander  Thomas E Standish  Thomas H Standley  Thomas M Johnston  Thomas M Stanek 

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