Jun O Xia, 65515 Dulcy Dr, York, PA 17404

5603947, Feb 18, 1997

Jul 21, 1994

8/278277

Ooi Wong - Fremont CA
Kathleen C. Farinas - San Francisco CA
Gary W. Cleary - Menlo Park CA
Chia-Ming Chiang - Foster City CA
Jun Xia - Redwood City CA

Cygnus Terapeutic Systems - Redwood City CA

A61F 1300

424448

A skin or buccal patch for providing nicotine replacement therapy which comprises a matrix type laminated composite in which the matrix is composed of a mixture of nicotine in a polymer wherein the amount of nicotine in the matrix, diffusion coefficient of nicotine in the matrix and the thickness of matrix are such that the release of nicotine is: (1) controlled by the patch; (2) rapid and at a relatively high flux over the prescribed wearing time of patch; and (3) such that a substantial proportion of the nicotine initially in the patch has been released at the end of the prescribed wearing time.

2018026, Sep 20, 2018

May 17, 2018

15/983085

- Ephrata PA, US
Jun Xia - York PA, US

A61K 31/7004
A61K 9/00
A61K 9/20
A61K 9/28
A61K 9/70
A61K 47/10
A61K 47/22
A61K 47/12
A61K 31/437
A61M 21/02

The present invention relates to compositions, devices and methods of delayed and sustained release of energy molecules for brain function. The composition comprises an energy molecule required for human brain function; wherein the release of the energy molecule is delayed and then sustained over a period of time. The methods comprise administering the composition subject in need thereof immediately prior to going to sleep. The present invention also relates to systems for brain stimulation during sleep and methods of use thereof. The system comprises a brain stimulation module and at least one of a brain energy source, a hypnotic source, or both. The methods involve administering to a subject a brain energy molecule, a hypnotic, or both and providing to the subject during restorative sleep a sensory stimulation.

2017030, Oct 26, 2017

Oct 20, 2015

15/521274

- Ephrata PA, US
Jun Xia - York PA, US

ABLE CEREBRAL, LLC - Ephrata PA

A61M 21/00
A61M 21/00
A61M 21/00
A61M 21/00
A61M 21/00
A61M 21/00

The present invention relates to systems for brain stimulation during sleep and methods for increasing vividness of a subject's dreams or for directing the subject matter of a subject's dreams. The system comprises a brain stimulation module and at least one of a brain energy source and/or a hypnotic source. The methods involve administering to a subject a brain energy molecule and/or a hypnotic and providing to the subject during restorative sleep a sensory stimulation.

2014018, Jun 26, 2014

Jul 13, 2012

14/232613

Jun Xia - York PA, US

A61K 9/28
A61K 9/48
A61K 31/19
A61K 31/7004

604290, 424468, 514 23, 424457, 514557, 604307

The present invention relates to compositions, devices and methods of delayed and sustained release of energy molecules for brain function to treat nocturnal hypoglycemia. The composition comprises an energy molecule required for human brain function; wherein the release of the energy molecule is delayed and then sustained over a period of time. The device is a transdermal delivery device comprising a reservoir layer containing the composition and a skin permeation enhancer formulation, an adhesive layer, a backing layer and a release liner. The method comprises administering the composition either orally or through the transdermal delivery device to a subject in need thereof immediately prior to going to sleep.