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Yun Xuan He, 54Lemont, IL

Yun He Phones & Addresses

Bolingbrook, IL   

5571 S Oak St, Hinsdale, IL 60521   

2904 Normal Ave, Chicago, IL 60616    312-3260928   

645 29Th St, Chicago, IL 60616   

Minneapolis, MN   

Naperville, IL   

645 W 29Th St, Chicago, IL 60616    312-4986336   

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Yun Xuan He

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Company: Gap Position: Senior account executive

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Degree: High school graduate or higher

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Yun He Photo 34

Senior Account Executive

Work:
Gap
Senior Account Executive

Publications & IP owners

Us Patents

3-Pyridyloxymethyl Heterocyclic Ether Compounds Useful In Controlling Chemical Synaptic Transmission

US Patent:
6437138, Aug 20, 2002
Filed:
Mar 1, 2000
Appl. No.:
09/472399
Inventors:
Nan-Horng Lin - Vernon Hills IL
Yun He - San Diego CA
Mark W. Holladay - Tucson AZ
Keith Ryther - Round Lake Park IL
Yihong Li - Grayslake IL
Hao Bai - Libertyville IL
Assignee:
Abbott Laboratories - Abbott Park IL
International Classification:
C07D40100
US Classification:
5462681, 5462764
Abstract:
Novel 3-pyridyloxymethyl heterocyclic ether compounds of the formula: or the pharmaceutically-acceptable salts or prodrugs thereof are selective and potent ligands at neuronal nicotinic cholinergic channel receptors, and are effective in controlling synaptic transmission. Key intermediates and processes using this key intermediates to produce compounds of formula I with the variables defined in the specification are also described.

Intermediates For The Preparation Of Enantiomerically-Pure-3-Methyl-5-(1-C1-C3-Alkyl)-2-Pyrrolidinyl)Isoxazol E

US Patent:
5508418, Apr 16, 1996
Filed:
Jun 7, 1995
Appl. No.:
8/477057
Inventors:
Nan-Horng Lin - Mundelein IL
Yun He - Zion IL
William H. Bunnelle - Mundelein IL
Assignee:
Abbott Laboratories - Abbott Park IL
International Classification:
C07D20706
C07D26104
C07D26106
US Classification:
548243
Abstract:
Novel compounds useful in the preparation of enantiomerically-pure 3-methyl-5-(1-(C. sub. 1 -C. sub. 3 -alkyl)-2-pyrrolidinyl)isoxazole in high yield, namely 5(S)-(3-methyl-5-isoxazolyl)-2-pyrrolidinone, 3-methyl-5-(1-methyl-2-pyrrolidinyl)-5-hydroxy-4,5-dihydro-isoxazole, and 1-(1-methyl-2(S)-pyrrolidinyl)-1,3-butanedione-3-oxime.

3-Pyridyloxymethyl Heterocyclic Ether Compounds Useful In Controlling Chemical Synaptic Transmission

US Patent:
5629325, May 13, 1997
Filed:
Jun 6, 1996
Appl. No.:
8/660044
Inventors:
Nan-Horng Lin - Mundelein IL
Yun He - San Diego CA
Mark W. Holladay - Libertyville IL
Keith Ryther - Round Lake Park IL
Yihong Li - Grayslake IL
Assignee:
Abbott Laboratories - Abbott Park IL
International Classification:
C07D40102
A61K 3144
US Classification:
514318
Abstract:
Novel 3-pyridyloxymethyl heterocyclic ether compounds of the formula: ##STR1## or the pharmaceutically-acceptable salts or prodrugs thereof are selective and potent ligands at neuronal nicotinic cholinergic channel receptors, and are effective in controlling synaptic transmission.

Method Of Preparing Enantiomerically-Pure 3-Methyl-5-(1-Alkyl-2(S)-Pyrrolidinyl) Isoxazoles

US Patent:
5559242, Sep 24, 1996
Filed:
Jan 25, 1996
Appl. No.:
8/591806
Inventors:
Nan-Horng Lin - Mundelein IL
Yun He - Zion IL
Steven J. Wittenberger - Mundelein IL
Assignee:
Abbott Laboratories - Abbott Park IL
International Classification:
C07D26106
US Classification:
548247
Abstract:
A novel process for preparing enantiomerically-pure 3-methyl-5-(1-(C. sub. 1 -C. sub. 3 -alkyl)-2-pyrrolidinyl)isoxazole in high yield, wherein a protected 2-oxo-pyrrolidine starting material is reacted with a suitable organic anion and a resulting beta-keto oxime intermediate is cyclized and dehydrated.

Heterocyclic Ether Compounds Useful In Controlling Neurotransmitter Release

US Patent:
5914328, Jun 22, 1999
Filed:
Jun 7, 1995
Appl. No.:
8/485537
Inventors:
Nan-Horng Lin - Mundelein IL
Mark W. Holladay - Libertyville IL
Melwyn A. Abreo - Imperial Beach CA
David E. Gunn - Waukegan IL
Suzanne A. Lebold - Chicago IL
Richard L. Elliott - Grayslake IL
Yun He - Zion IL
Assignee:
Abbott Laboratories - Abbott Park IL
International Classification:
C07D40112
C07D40312
C07D41712
A61K 31505
A61K 3150
A61K 31495
A61K 31425
US Classification:
514252
Abstract:
Novel heterocyclic ether compounds of the formula: ##STR1## wherein *, A,B, n, R. sup. 1, R. sup. 2 and X are specifically defined, or pharmaceutically-acceptable salts or prodrugs thereof, which are useful in selectively activating or inhibiting neurotransmitter release; to therapeutically-effective pharmaceutical compositions of these compounds; and to the use of said compositions to activate or inhibit neurotransmitter release in mammals.

3-Pyridyloxymethyl Heterocyclic Ether Compounds Useful In Controlling Chemical Synaptic Transmission

US Patent:
6127386, Oct 3, 2000
Filed:
Apr 18, 1997
Appl. No.:
8/844540
Inventors:
Nan-Horng Lin - Mundelein IL
Yun He - Zion IL
Mark W. Holladay - Libertyville IL
Keith B. Ryther - Round Lake Park IL
Yihong Li - Grayslake IL
Hao Bai - Grayslake IL
Assignee:
Abbott Laboratories - Abbott Park IL
International Classification:
A61K 3144
C07D47102
C07D21330
US Classification:
514318
Abstract:
Novel 3-pyridyloxymethyl heterocyclic ether compounds of the formula: ##STR1## or the pharmaceutically-acceptable salts or prodrugs thereof are selective and potent ligands at neuronal nicotinic cholinergic channel receptors, and are effective in controlling synaptic transmission. Key intermediates and processes using this key intermediates to produce compounds of formula I with the variables defined in the specification are also described.

Isoxazole, Isothiazole And Pyrazole Compounds That Enhance Cognitive Function

US Patent:
5409946, Apr 25, 1995
Filed:
Sep 8, 1993
Appl. No.:
8/118079
Inventors:
David S. Garvey - Lake Forest IL
George M. Carrera - Des Plaines IL
Stephen P. Arneric - Lindenhurst IL
Youe-Kong Shue - Sudbury MA
Nan-Horng Lin - Mundelein IL
Yun He - Milwaukee WI
Edmund L. Lee - Lake Zurich IL
Suzanne A. Lebold - Chicago IL
Assignee:
Abbott Laboratories - Abbott Park IL
International Classification:
A61K 3142
A61K 31425
C07D21180
US Classification:
514372
Abstract:
Novel isoxazole isothiazole and pyrazole compounds of the formula: ##STR1## wherein A, R. sup. 1, and R. sup. 2 are specifically defined, or pharmaceutical salts thereof, are selective and potent cholinergic ligands at neuronal nicotinic receptors, useful in the treatment of cognitive, neurological and mental disorders characterized by decreased cholinergic function, as well as in the treatment of alcohol intoxication and petit real absence epilepsy.

Method Of Preparing Enantiomerically-Pure 3-Methyl-5-(1-Alkyl-2(S)-Pyrrolidinyl) Isoxazoles

US Patent:
5424444, Jun 13, 1995
Filed:
Apr 28, 1994
Appl. No.:
8/234442
Inventors:
Nan-Horng Lin - Mundelein IL
Yun He - Milwaukee WI
Richard L. Elliott - Grayslake IL
Mukund S. Chorghade - Gurnee IL
Thomas K. J. Esch - Hohentengen, DE
Dieter O. Beer - Waldshut-Tiengen, DE
Christian C. Witzig - Zurich, CH
Thomas C. Herzig - Oberentfelden, CH
Steven J. Wittenberger - Mundelein IL
William H. Bunnelle - Mundelein IL
Bikshandar A. Narayanan - Mundelein IL
Pulla R. Singam - Waukegan IL
Alla V. Rama Rao - Hyderabad, IN
Assignee:
Abbott Laboratories - Abbott Park IL
International Classification:
C07D26108
US Classification:
548247
Abstract:
A novel process for preparing enantiomerically-pure 3-methyl-5-(1-(C. sub. 1 -C. sub. 3 -alkyl)-2-pyrrolidinyl)isoxazole in high yield, wherein a protected pyrrolidine or 2-oxo-pyrrolidine starting material is reacted with a suitable organic anion and a resulting beta-keto oxime intermediate is cyclized and dehydrated, as well as intermediates useful in the preparation thereof.

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