Hui Zhang Zhang, 61104 Warwick Dr, Wilmington, DE 19803

6377972, Apr 23, 2002

Jan 19, 1999

09/233407

Katherine Hua Guo - Eatontown NJ
Markus Andreas Hofmann - Tinton Falls NJ
Tze Sing Eugene Ng - Pittsburgh PA
Sanjoy Paul - Marlboro NJ
Hui Zhang - Pittsburgh PA

Lucent Technologies Inc. - Murray Hill NJ

G06F 1516

709201, 709231, 709238

A new architecture and operational techniques for supporting high quality live and on-demand streaming multimedia on a data network. By using Helper machines inside the network as data forwarding, caching, and buffering agents, and by forming meshes among Helper machines, advantages of homogeneous, synchronous multicast transmission and of heterogeneous, asynchronous reception are achieved. The architecture provides essentially transparently support to the receivers for near-zero start-up latency, improved playback quality, improved CR-like operations. These are achieved while reducing network and server load compared to todays multimedia networking techniques.

6653443, Nov 25, 2003

Apr 8, 2002

10/118575

Hui Zhang - Philadelphia PA
Roger J. Pomerantz - Chalfont PA
Bin Yang - Bala Cynwyd PA

Thomas Jefferson University - Philadelphia PA

A61K 3804

530327, 530324, 530325, 530326, 530826

One approach to treating individuals infected with HIV-1 is to administer to such individuals compounds that directly interfere with and intervene in the machinery by which HIV-1 replicates itself within human cells. Although the specific role of HIV-1 viral protein Vif in the viral life cycle is not known, the vif gene is essential for the pathogenic replication of lentiviruses in vivo. The present invention relates to a method for treating an individual exposed to or infected with HIV-1. Individuals identified as being exposed to or infected by HIV-1 are administered a therapeutically effective amount of one or more compounds that inhibit or prevent replication of said HIV-1 by interfering with the replicative or other essential functions of HIV-1 viral protein Vif, by interactively blocking the multimerization domain of Vif, thereby preventing multimerization of Vif protein, which is important for Vif function in the lentivirus life cycle. In preferred embodiments, the compound or compounds that interactively block the multimerization domain of Vif are Vif antagonists. Pharmaceutical compositions comprising these compounds are also disclosed.

7226741, Jun 5, 2007

Oct 17, 2003

10/688100

Hui Zhang - Philadelphia PA, US
Roger J. Pomerantz - Chalfont PA, US
Bin Yang - Bala Cynwyd PA, US

Thomas Jefferson University - Philadelphia PA

C12Q 1/68

435 6, 435 911, 435 9133

One approach to treating individuals infected with HIV-1 is to administer to such individuals compounds that directly interfere with and intervene in the machinery by which HIV-1 replicates itself within human cells. Although the specific role of HIV-1 viral protein Vif in the viral life cycle is not known, the vif gene is essential for the pathogenic replication of lentiviruses in vivo. The present invention relates to a method for treating an individual exposed to or infected with HIV-1. Individuals identified as being exposed to or infected by HIV-1 are administered a therapeutically effective amount of one or more compounds that inhibit or prevent replication of said HIV-1 by interfering with the replicative or other essential functions of HIV-1 viral protein Vif by interactively blocking the multimerization domain of Vif, thereby preventing multimerization of Vif protein, which is important for Vif function in the lentivirus life cycle. In preferred embodiments, the compound or compounds that interactively block the multimerization domain of Vif are Vif antagonists. Pharmaceutical compositions comprising these compounds are also disclosed.

7398312, Jul 8, 2008

Mar 29, 2000

09/538351

Katherine H. Guo - Eatontown NJ, US
Markus A. Hofmann - Tinton Falls NJ, US
Sanjoy Paul - Marlboro NJ, US
Tze Sing Eugene Ng - Pittsburgh PA, US
Hui Zhang - Pittsburgh PA, US

Lucent Technologies Inc. - Murray Hill NJ

G06F 15/173
G06F 15/16
G06F 12/00
G06F 13/00
G06F 13/28

709226, 709225, 709231, 711118

An apparatus and method to enhance existing caches in a network to better support streaming media storage and distribution. Helper machines are used inside the network to implement several methods which support streaming media including segmentation of streaming media objects into smaller units, cooperation of Helper machines, and novel placement and replacement policies for segments of media objects.

7498138, Mar 3, 2009

Jun 4, 2007

11/809953

Hui Zhang - Philadelphia PA, US
Roger J. Pomerantz - Chalfont PA, US
Bin Yang - Bala Cynwyd PA, US

Thomas Jefferson University - Philadelphia PA

C12Q 1/68

435 6, 435 911

The HIV-1 protein Vif comprises a multimerization domain that allows Vif-Vif interaction and Vif multimerization, which is important for Vif function in the HIV-1 life-cycle. A method for screening for an antagonist of Vif comprises contacting the multimerization domain of Vif with a test compound that specifically binds the multimerization domain. Antagonists identified by the screening assay inhibit Vif multimerization. The antagonists inhibit essential functions of Vif and accordingly are useful as inhibitors of HIV-1 replication.

7526564, Apr 28, 2009

Mar 4, 2002

10/090110

Katherine Hua Guo - Eatontown NJ, US
Markus Andreas Hofmann - Tinton Falls NJ, US
Tze Sing Eugene Ng - Pittsburgh PA, US
Sanjoy Paul - Marlboro NJ, US
Hui Zhang - Pittsburgh PA, US

Alcatel-Lucent USA Inc. - Murray Hill NJ

G06F 15/16

709231, 709235

A new architecture and operational techniques for supporting high quality live and on-demand streaming multimedia on a data network. By using Helper machines inside the network as data forwarding, caching, and buffering agents, and by forming meshes among Helper machines, advantages of homogeneous, synchronous multicast transmission and of heterogeneous, asynchronous reception are achieved. The architecture provides essentially transparently support to the receivers for near-zero start-up latency, improved playback quality, improved CR-like operations. These are achieved while reducing network and server load compared to today's multimedia networking techniques.

7639611, Dec 29, 2009

Mar 10, 2006

11/372898

Fang Hao - Morganville NJ, US
Muralidharan Sampath Kodialam - Marlboro NJ, US
Hui Zhang - New Brunswick NJ, US

Alcatel-Lucent USA Inc. - Murray Hill NJ

G01R 31/08

370230

The invention includes a method and apparatus for generating a coincidence count table adapted for determining at least one flow statistic. The method includes receiving a plurality of packets comprising a respective plurality of payloads, comparing payloads associated with consecutive ones of the plurality of packets for identifying at least one simple pattern included within the compared payloads of the consecutive ones of the plurality of packets, for each of the consecutive ones of the plurality of packets, if the at least one simple pattern is identified, processing the at least one simple pattern to form a complex pattern, and for each complex pattern, updating a coincidence count associated with the complex pattern, wherein the coincidence counts are adapted for determining at least one flow statistic.

7840618, Nov 23, 2010

Dec 28, 2006

11/616925

Hui Zhang - New Brunswick NJ, US
Aniruddha Bohra - Edison NJ, US
Samrat Ganguly - Monmouth Junction NJ, US
Rauf Izmailov - Plainsboro NJ, US
Jian Liang - Brooklyn NJ, US

NEC Laboratories America, Inc. - Princeton NJ

G06F 17/30

707827, 711154, 711155, 711156

Traditional networked file systems like NFS do not extend to wide-area due to network latency and dynamics introduced in the WAN environment. To address that problem, a wide-area networked file system is based on a traditional networked file system (NFS/CIFS) and extends to the WAN environment by introducing a file redirector infrastructure residing between the central file server and clients. The file redirector infrastructure is invisible to both the central server and clients so that the change to NFS is minimal. That minimizes the interruption to the existing file service when deploying WireFS on top of NFS. The system includes an architecture for an enterprise-wide read/write wide area network file system, protocols and data structures for metadata and data management in this system, algorithms for history based prefetching for access latency minimization in metadata operations, and a distributed randomized algorithm for the implementation of global LRU cache replacement scheme.