Aaron L Downey, 471106 Sophomore Ct, Durham, NC 27713
Aaron Downey Phones & Addresses
1106 Sophomore Ct, Durham, NC 27713
Mattaponi, VA
Carrboro, NC
Wake, VA
1407 Toms Creek Rd, Blacksburg, VA 24060 540-9512339
Cape Canaveral, FL
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Aar Downey
Aaron Downey (born August 27, 1974) is a retired Canadian professional ice hockey forward.
Us Patents
Morphic Forms Of 4-Amino-7-(3,4-Dihydroxy-5-(Hydroxymethyl)Tetrahydrofuran-2-Yl)-2-Methyl-7H-Pyrrolo[2,3-D]Pyrimidine-5-Carboxamide And Uses Thereof
US Patent:
2020027, Sep 3, 2020
Filed:
Sep 21, 2018
Appl. No.:
16/645876
Inventors:
- Durham NC, US
Venkat LAKSHMANAN - Durham NC, US
Aaron Leigh DOWNEY - Durham NC, US
Venkat LAKSHMANAN - Durham NC, US
Aaron Leigh DOWNEY - Durham NC, US
International Classification:
C07H 19/14
Abstract:
The present disclosure relates to crystalline morphic forms of 4-amino-7-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl) tetrahydrofuran-2-yl)-2-methyl-7H-pyrrolo[2,3-d]pyrimidine-5-carboxamide. The morphic form can be a stable hemihydrate crystalline form.
Pyrrolopyrimidine Nucleosides And Analogs Thereof
US Patent:
2020019, Jun 25, 2020
Filed:
Aug 6, 2019
Appl. No.:
16/533194
Inventors:
- Durham NC, US
- Ann Arbor MI, US
Aaron Leigh DOWNEY - Durham NC, US
John C. DRACH - Ann Arbor MI, US
Andrew Louis MCIVER - Durham NC, US
Bradley David ROBERTSON - Durham NC, US
Dean Wallace SELLESETH - Durham NC, US
Phiroze Behram SETHNA - Durham NC, US
Leroy TOWNSEND - Ann Arbor MI, US
Roy W. WARE - Durham NC, US
- Ann Arbor MI, US
Aaron Leigh DOWNEY - Durham NC, US
John C. DRACH - Ann Arbor MI, US
Andrew Louis MCIVER - Durham NC, US
Bradley David ROBERTSON - Durham NC, US
Dean Wallace SELLESETH - Durham NC, US
Phiroze Behram SETHNA - Durham NC, US
Leroy TOWNSEND - Ann Arbor MI, US
Roy W. WARE - Durham NC, US
International Classification:
C07H 19/14
C07H 19/16
C07D 239/70
C07H 19/16
C07D 239/70
Abstract:
The present disclosure provides pyrrolopyrimidine nucleoside analogs of the Formula I, Formula IA, Formula IB, or Formula II and phospholipid conjugates and pharmaceutical compositions thereof wherein Rand A are defined herein. Also presented are methods of treating and/or preventing viral infection and/or viral infection-associated disease or disorder with one or more compounds of Formula I, Formula IA, Formula IB, or Formula II.
Morphic Forms Of Hexadecyloxypropyl-Phosphonate Esters And Methods Of Synthesis Thereof
US Patent:
2020009, Mar 26, 2020
Filed:
Oct 11, 2019
Appl. No.:
16/599392
Inventors:
- Durham NC, US
Aaron Leigh DOWNEY - Durham NC, US
Aaron Leigh DOWNEY - Durham NC, US
International Classification:
C07D 239/47
C07F 9/6512
C07F 9/6512
Abstract:
The disclosure describes methods of synthesis of phosphonate ester compounds. The methods according to the disclosure allow for large-scale preparation of phosphonate ester compounds having high purity and stability. Also disclosed are morphic forms of phosphonate ester compounds.
Morphic Forms Of Hexadecyloxypropyl-Phosphonate Esters And Methods Of Synthesis Thereof
US Patent:
2019001, Jan 17, 2019
Filed:
Sep 19, 2018
Appl. No.:
16/135171
Inventors:
- Durham NC, US
Aaron Leigh DOWNEY - Durham NC, US
Aaron Leigh DOWNEY - Durham NC, US
International Classification:
C07D 239/47
C07F 9/6512
C07F 9/6512
Abstract:
The disclosure describes methods of synthesis of phosphonate ester compounds. The methods according to the disclosure allow for large-scale preparation of phosphonate ester compounds having high purity and stability. Also disclosed are morphic forms of phosphonate ester compounds.
Morphic Forms Of Hexadecyloxypropyl-Phosphonate Esters And Methods Of Synthesis Thereof
US Patent:
2018008, Mar 29, 2018
Filed:
Dec 1, 2017
Appl. No.:
15/828935
Inventors:
- Durham NC, US
Aaron Leigh Downey - Durham NC, US
Aaron Leigh Downey - Durham NC, US
International Classification:
C07D 239/47
C07F 9/6512
C07F 9/6512
Abstract:
The disclosure describes methods of synthesis of phosphonate ester compounds. The methods according to the disclosure allow for large-scale preparation of phosphonate ester compounds having high purity and stability. Also disclosed are morphic forms of phosphonate ester compounds.
Pyrrolopyrimidine Nucleosides And Analogs Thereof
US Patent:
2017025, Sep 7, 2017
Filed:
May 18, 2017
Appl. No.:
15/599056
Inventors:
- Durham NC, US
- Ann Arbor MI, US
Aaron Leigh Downey - Durham NC, US
John C. Drach - Ann Arbor MI, US
Andrew Louis McIver - Durham NC, US
Bradley David Robertson - Durham NC, US
Dean Wallace Selleseth - Cary NC, US
Phiroze Behram Sethna - Durham NC, US
Leroy Townsend - Ann Arbor MI, US
Roy W. Ware - Raleigh NC, US
- Ann Arbor MI, US
Aaron Leigh Downey - Durham NC, US
John C. Drach - Ann Arbor MI, US
Andrew Louis McIver - Durham NC, US
Bradley David Robertson - Durham NC, US
Dean Wallace Selleseth - Cary NC, US
Phiroze Behram Sethna - Durham NC, US
Leroy Townsend - Ann Arbor MI, US
Roy W. Ware - Raleigh NC, US
International Classification:
C07H 19/14
C07H 19/16
C07H 19/16
Abstract:
The present disclosure provides pyrrolopyrimidine nucleoside analogs of the Formula I, Formula IA, Formula IB, or Formula II and phospholipid conjugates and pharmaceutical compositions thereof wherein Rand A are defined herein. Also presented are methods of treating and/or preventing viral infection and/or viral infection-associated disease or disorder with one or more compounds of Formula I, Formula IA, Formula IB, or Formula II.
Branched Chain Acyclic Nucleoside Phosphonate Esters And Methods Of Synthesis And Uses Thereof
US Patent:
2017002, Feb 2, 2017
Filed:
Dec 5, 2014
Appl. No.:
15/101647
Inventors:
- Durham NC, US
Aaron L. DOWNEY - Durham NC, US
Ernest Randall LANIER - Chapel Hill NC, US
Phiroze SETHNA - Durham NC, US
Dean SELLESETH - Durham NC, US
Aaron L. DOWNEY - Durham NC, US
Ernest Randall LANIER - Chapel Hill NC, US
Phiroze SETHNA - Durham NC, US
Dean SELLESETH - Durham NC, US
International Classification:
C07F 9/6512
A61K 31/675
A61K 45/06
A61K 31/675
A61K 45/06
Abstract:
The present invention is directed to branched chain nucleoside phosphonate ester compounds and methods of synthesis thereof. The present invention is also directed to pharmaceutical compositions comprising branched chain nucleoside phosphonate ester compounds and methods of treating and/or preventing double stranded DNA viral infection and/or viral infection associated disease or disorder.
Morphic Forms Of Hexadecyloxypropyl-Phosphonate Esters And Methods Of Synthesis Thereof
US Patent:
2016026, Sep 15, 2016
Filed:
May 20, 2016
Appl. No.:
15/160885
Inventors:
- Durham NC, US
Aaron Leigh Downey - Durham NC, US
Aaron Leigh Downey - Durham NC, US
International Classification:
C07D 239/47
Abstract:
The disclosure describes methods of synthesis of phosphonate ester compounds. The methods according to the disclosure allow for large-scale preparation of phosphonate ester compounds having high purity and stability. Also disclosed are morphic forms of phosphonate ester compounds.
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