Aaron B Weber, 4826 Lake St #1, Arlington, MA 02474

7397546, Jul 8, 2008

Mar 8, 2006

11/370605

Aaron Weber - Cambridge MA, US
David H. Tracy - Norwalk CT, US

Helicos Biosciences Corporation - Cambridge MA

G01J 1/00

356121

A method of increasing the spatial uniformity of the detected intensity of a beam of light from a laser in a system including the laser and a light detector. In one embodiment the method includes the steps of generating a beam of light with the laser; and moving the beam of light and the light detector relative to each other, such that the detector averages the spatial intensity of the beam of light over time. In another embodiment the invention relates to a system for increasing the detected spatial uniformity of the intensity of a beam of light. In one embodiment the system comprises a light detector; a laser source for generating the beam of light; and a means for moving the beam of light and the detector relative to one another such that the detector averages the intensity of the light beam over time.

2008000, Jan 10, 2008

Nov 13, 2006

11/598516

John H. Kepler - Combridge MA, US
Aaron Weber - Cambridge MA, US
Parris Saxon Wellman - Reading MA, US

Helicos Biosciences Corporation - Cambridge MA

G02B 13/22

359663

In one aspect, the invention relates to an optical apparatus for producing light of a predetermined intensity from light sources of less than the predetermined intensity. In one embodiment the apparatus includes a first light source; a second light source; a double dove anti-Gaussian generator in optical communication with the first light source; and a compensator in optical communication with the second light source. Light from the first light source passes through the double dove anti-Gaussian generator and light from the second light source passes through the compensator, and are combined to produce a flattened Gaussian intensity distribution. In another aspect, the invention relates to a method and apparatus for separating an image into subunits and reading the separate subimages out of the detectors in parallel.

2008003, Feb 7, 2008

Jul 5, 2006

11/481403

John H. Kepler - Cambridge MA, US
Aaron Weber - Cambridge MA, US
Parris Saxon Wellman - Reading MA, US

Helicos Biosciences Corporation - Cambridge MA

G01B 9/00
H04N 5/225
H04N 9/04

356124, 34820799

In one aspect, the invention relates to an optical apparatus for producing light of a predetermined intensity from light sources of less than the predetermined intensity. In one embodiment the apparatus includes a first light source; a second light source; a double dove anti-Gaussian generator in optical communication with the first light source; and a compensator in optical communication with the second light source. Light from the first light source passes through the double dove anti-Gaussian generator and light from the second light source passes through the compensator, and are combined to produce a flattened Gaussian intensity distribution. In another aspect, the invention relates to a method and apparatus for separating an image into subunits and reading the separate subimages out of the detectors in parallel.

2008030, Dec 18, 2008

Mar 5, 2008

12/043077

Aaron Weber - Cambridge MA, US
David H. Tracy - Norwalk CT, US

G01J 1/00

356121

A method of increasing the spatial uniformity of the detected intensity of a beam of light from a laser in a system including the laser and a light detector. In one embodiment the method includes the steps of generating a beam of light with the laser; and moving the beam of light and the light detector relative to each other, such that the detector averages the spatial intensity of the beam of light over time. In another embodiment the invention relates to a system for increasing the detected spatial uniformity of the intensity of a beam of light. In one embodiment the system comprises a light detector; a laser source for generating the beam of light; and a means for moving the beam of light and the detector relative to one another such that the detector averages the intensity of the light beam over time.

2022037, Nov 24, 2022

May 18, 2022

17/747645

Sepehr Kiani - Watertown MA, US
Aaron Weber - Watertown MA, US
Robert Meltzer - Belmont MA, US

Fluent Biosciences Inc. - Watertown MA

C12Q 1/6825
C12Q 1/686

This invention releases to systems and methods for detecting the presence and quantity of a target nucleic acid in a sample using dPCR and PIP encapsulated monodisperse droplets.

2021039, Dec 23, 2021

May 4, 2021

17/307521

- Medford MA, US
Gregory Ellson - Cambridge MA, US
Desai Chen - Arlington MA, US
Javier Ramos - Boston MA, US
Davide Marini - Medford MA, US
Aaron Weber - Arlington MA, US

B29C 64/135
B29C 64/205

An approach to improving optical scanning increases the strength of optical reflection from the build material during fabrication. In some examples, the approach makes use of an additive (or a combination of multiple additives) that increases the received signal strength and/or improves the received signal-to-noise ratio in optical scanning for industrial metrology. Elements not naturally present in the material are introduced in the additives in order to increase fluorescence, scattering or luminescence. Such additives may include one or more of: small molecules, polymers, peptides, proteins, metal or semiconductive nanoparticles, and silicate nanoparticles.

2021025, Aug 19, 2021

May 4, 2021

17/307487

- Medford MA, US
Aaron Weber - Arlington MA, US
Desai Chen - Arlington MA, US
Gregory Ellson - Cambridge MA, US
Javier Ramos - Boston MA, US
Davide Marini - Medford MA, US

B29C 64/112
G01N 21/88
G02B 26/10
B29C 64/40
B29C 64/268
B33Y 10/00

A method for additive manufacturing includes forming an object including depositing a first material including a first coloring component and a second material including a second coloring component, wherein both the first material and the second material further include a corresponding fluorescent component, scanning the object, including causing an emission of an optical signal from the object, wherein the emission of the optical signal is caused at least in part by an emission from the fluorescent components interacting with the first coloring component and the second coloring component as it passes from the fluorescent components to the surface of the object, sensing the emission of the optical signal, and determining presence of the first material and the second material based at least in part on the sensed emission of the optical signal.

2014035, Dec 4, 2014

May 29, 2014

14/289982

- Cambridge MA, US
Aaron Weber - Arlington MA, US
Peter Stokes - Cambridge MA, US

GnuBIO, Inc. - Cambridge MA

G01P 3/38
G01B 11/14
G01P 5/00

348 79, 348135

Systems and methods are provided for determining a velocity or an inflation rate of a droplet in a microfluidic channel. The droplet is exposed to two or more temporally separated flashes of light, each flash including light of one wavelength band, and imaged using a detector configured to distinguish light in the wavelength bands. Two or more images of the droplet are acquired, each corresponding to one of the flashes, and all within a single video frame or photographic exposure. The images can be processed separately and the position or size of the droplet in each image is calculated. A velocity or inflation rate is then determined by dividing the change in position or size by the amount of time allowed to pass between the flashes.