Inventors:
- Burnaby, CA
Richard J. HOLLAND - Vancouver, CA
Adam JUDGE - Bainbridge Island WA, US
Amy C. H. LEE - Burnaby, CA
Alan D. MARTIN - Vancouver, CA
Nicholas Michael SNEAD - San Francisco CA, US
Emily P. THI - Coquitlam, CA
Mark WOOD - Port Moody, CA
Xin YE - Richmond, CA
Assignee:
ARBUTUS BIOPHARMA CORPORATION - Burnaby BC
International Classification:
C12N 15/113
Abstract:
The invention provides certain nucleic acids (e.g., double stranded siRNA molecules), as well as conjugates that comprise a targeting moiety, a double stranded siRNA, and optional linking groups. Certain embodiments also provide synthetic methods useful for preparing the conjugates. The conjugates are useful to target therapeutic double stranded siRNA to the liver and to treat liver diseases including hepatitis (e.g. hepatitis B and hepatitis D).