Thomas Adrian resumes & CV records
Resumes
Thomas Adrian
Thomas Adrian
Thomas Adrian
Location:
United States
Thomas R Adrian, 671403 Kimberly Rd, Anderson, SC 29621
Thomas Adrian Phones & Addresses
1403 Kimberly Rd, Anderson, SC 29621 864-3759708
Des Plaines, IL
Bellingham, WA
Glenview, IL
Chicago, IL
Mentions for Thomas R Adrian
Publications & IP owners
Us Patents
Anticancer Glycoside Compounds
US Patent:
7144867, Dec 5, 2006
Filed:
Jan 27, 2005
Appl. No.:
11/044496
Inventors:
Thomas E. Adrian - Chicago IL, US
Peter D. Collin - Sunset ME, US
Peter D. Collin - Sunset ME, US
Assignee:
Northwestern University - Evanston IL
Coastside Bio Resources - Stonington ME
Coastside Bio Resources - Stonington ME
International Classification:
A01N 43/04
A61K 31/70
A01N 57/00
A61K 31/665
A61K 31/70
A01N 57/00
A61K 31/665
US Classification:
514 33, 514 35, 514 54, 514 27, 514 99, 514100
Abstract:
The present invention relates to new classes of anti-cancer compounds. In particular, the present invention provides glycoside compounds as anti-cancer agent, alone, or in combination with other anti-cancer agents or therapies.
Compositions And Methods For The Treatment And Prevention Of Cancer
US Patent:
7335382, Feb 26, 2008
Filed:
Feb 25, 2005
Appl. No.:
11/066802
Inventors:
Thomas E. Adrian - Chicago IL, US
Peter D. Collin - Sunset ME, US
Peter D. Collin - Sunset ME, US
Assignee:
Northwestern University - Evanston IL
International Classification:
A61K 35/36
A61K 35/12
A61K 35/12
US Classification:
424574, 424520
Abstract:
The present invention relates to new classes of anti-cancer agents. In particular, the present invention provides materials derived from natural sources as anti-cancer agents, alone, or in combination with other anti-cancer agents or therapies.
Compositions Derived From And Methods For Making And Using Same
US Patent:
7387797, Jun 17, 2008
Filed:
Mar 22, 2001
Appl. No.:
10/239345
Inventors:
Peter D. Collin - Sunset ME, US
Thomas E. Adrian - Chicago IL, US
Thomas E. Adrian - Chicago IL, US
Assignee:
Creighton University - Omaha NE
International Classification:
A61K 35/56
A61K 9/14
A61K 9/14
US Classification:
424547, 424400, 424489, 424520
Abstract:
Disclosed are compositions which include an isolated soft tissue from (“MM”) and compositions which include an oil isolated from MM or a portion thereof. Also disclosed are methods of treating adenocarcinoma in a subject; methods of decreasing proliferation of adenocarcinoma cells, or of inducing apoptosis of adenocarcinoma cells, or of inducing differentiation of adenocarcinoma cells into non-cancerous cells; methods of inhibiting the activity of 5-lipoxygenase or 12-lipoxygenase or both in cells; and methods of treating a subject suffering from a disease or condition associated with excessive 5-lipoxygenase activity or 12-lipoxygenase activity or both. A process for preparing an MM extract by contacting MM or a portion thereof with a solvent under conditions effective to extract one or more materials from the MM or portion thereof is also described.
Cyclic Peptide Antitumor Agents
US Patent:
7709443, May 4, 2010
Filed:
Oct 8, 2004
Appl. No.:
10/962168
Inventors:
Richard B. Silverman - Northbrook IL, US
Shouxin Liu - Evanston IL, US
Wenxin Gu - Evanston IL, US
Thomas E. Adrian - Chicago IL, US
Gerald A. Soff - Wilmette IL, US
Shouxin Liu - Evanston IL, US
Wenxin Gu - Evanston IL, US
Thomas E. Adrian - Chicago IL, US
Gerald A. Soff - Wilmette IL, US
Assignee:
Northwestern University - Evanston IL
International Classification:
A61K 38/00
US Classification:
514 9
Abstract:
Cyclic peptide compounds and derivatives thereof having antitumor activity as shown by treatment of human melanoma, pancreatic, breast, prostate cancer cells.
Cyclic Peptide Antitumor Agents
US Patent:
8058244, Nov 15, 2011
Filed:
Mar 11, 2010
Appl. No.:
12/722026
Inventors:
Richard B. Silverman - Northbrook IL, US
Shouxin Liu - Evanston IL, US
Wenxin Gu - Evanston IL, US
Thomas E. Adrian - Chicago IL, US
Gerald A. Soff - Wilmette IL, US
Shouxin Liu - Evanston IL, US
Wenxin Gu - Evanston IL, US
Thomas E. Adrian - Chicago IL, US
Gerald A. Soff - Wilmette IL, US
Assignee:
Northwestern University - Evanston IL
International Classification:
A61K 38/00
US Classification:
514 193
Abstract:
Cyclic peptide compounds and derivatives thereof having antitumor activity as shown by treatment of human melanoma, pancreatic, breast, prostate cancer cells.
Cyclic Peptide Antitumor Agents
US Patent:
8492345, Jul 23, 2013
Filed:
Nov 14, 2011
Appl. No.:
13/295653
Inventors:
Richard B. Silverman - Northbrook IL, US
Shouxin Liu - Evanston IL, US
Wenxin Gu - Evanston IL, US
Thomas E. Adrian - Chicago IL, US
Gerald A. Soff - Wilmette IL, US
Shouxin Liu - Evanston IL, US
Wenxin Gu - Evanston IL, US
Thomas E. Adrian - Chicago IL, US
Gerald A. Soff - Wilmette IL, US
Assignee:
Northwestern University - Evanston IL
International Classification:
A61K 38/00
A61P 35/00
A61P 35/00
US Classification:
514 193, 514 194, 514 195
Abstract:
Cyclic peptide compounds and derivatives thereof having antitumor activity as shown by treatment of human melanoma, pancreatic, breast, prostate cancer cells.
Methods For Inhibiting Proliferation And Inducing Apoptosis In Cancer Cells
US Patent:
2004005, Mar 18, 2004
Filed:
Jun 2, 2003
Appl. No.:
10/275590
Inventors:
Thomas Adrian - Chicago IL, US
International Classification:
A61K031/47
A61K031/095
A61K031/075
A61K031/095
A61K031/075
US Classification:
514/311000, 514/706000, 514/718000
Abstract:
Disclosed are methods of decreasing proliferation of adenocarcinoma cancer cells, or of inducing apoptosis of adenocarcinoma cancer cells, or of inducing differentiation of adenocarcinoma cancer cells into non-cancerous cells. One such method includes contacting the adenocarcinoma cancer cells with a compound under conditions effective for the compound to inhibit binding of leukotriene B4 to leukotriene B4 receptor. In another such method, the method includes contacting the adenocarcinoma cancer cells with 2-(2-propyl-3-(3-(2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)phenoxy)benzoic acid or a pharmaceutically acceptable salt, solvate, or congener thereof. Also disclosed are methods of treating adenocarcinomas in a subject. One method includes administering to the subject an amount of a compound effective to inhibit binding of leukotriene B4 to leukotriene B4 receptor. Another method includes administering 2-(2-propyl-3-(3-(2-ethyl-4-(4-fluoropheyl)-5-hydroxyphenoxy)propoxy)phenoxy)benzoic acid or a pharmaceutically acceptable salt, solvate, or congener thereof, to the subject.
Methods For Inducing Apoptosis And Inhibiting Proliferation In Cancer Cells
US Patent:
2004007, Apr 15, 2004
Filed:
Nov 24, 2003
Appl. No.:
10/451555
Inventors:
Thomas Adrian - Chicago IL, US
Peter Collin - Sunset ME, US
Peter Collin - Sunset ME, US
International Classification:
A61K031/202
US Classification:
514/560000
Abstract:
Disclosed are methods of decreasing proliferation of adenocarcinoma cells, or of inducing apoptosis of adenocarcinoma cells, or of inducing differentiation of adenocarcinoma cells into non-cancerous cells. The methods include contacting a sample comprising adenocarcinoma cells with a compound having the formula (“Formula I”): CH—(CH)—CH CH—(CH)—COOH) wherein n is an integer from 0 to 15, m is an integer from about 1 to 16, and the sum of m and n is an integer from 6 to 16, or a pharmaceutically acceptable ester, salt, amide, solvate, or metabolite thereof. Also disclosed are methods for treating adenocarcinoma in a subject. The methods include administering to the subject an effective amount of a compound having Formula I or a pharmaceutically acceptable ester, salt, amide, solvate, or metabolite thereof.
NOTICE: You may not use BackgroundCheck or the information it provides to make decisions about employment, credit, housing or any other purpose that would require Fair Credit Reporting Act (FCRA) compliance. BackgroundCheck is not a Consumer Reporting Agency (CRA) as defined by the FCRA and does not provide consumer reports.