Inventors:
Evangeline Cruz - Hayward CA, US
Atul Ayer - Palo Alto CA, US
Brenda Pollock - Cupertino CA, US
Carmelita Garcia - Newark CA, US
Sherry Li - Cupertino CA, US
Alfredo Wong - Sunnyvale CA, US
Lawrence Hamel - Mountain View CA, US
Cheri Klein - Northbrook IL, US
Yihong Qiu - Vernon Hills IL, US
Ye Huang - Gurnee IL, US
International Classification:
A61K031/485
A61K031/16
A61K009/22
US Classification:
424468000, 514282000, 514629000
Abstract:
Sustained release dosage forms for twice daily oral dosing to a human patient for providing relief from pain are provided. The sustained release dosage form comprises an immediate release component and a sustained release component, wherein the immediate release component and the sustained release component collectively contain a therapeutically effective amount of an opioid analgesic and a therapeutically effective amount of nonopioid analgesic. In a preferred embodiment, the nonopioid analgesic is acetaminophen and the opioid analgesic is hydrocodone and pharmaceutically acceptable salts thereof, and in preferred embodiments, the pharmaceutically acceptable salt is bitartrate. The dosage forms produce plasma profiles in a patient characterized by a Cmax for hydrocodone of between about 0.6 ng/mL/mg to about 1.4 ng/mL/mg and an AUC for hydrocodone of between about 9.1 ng*hr/mL/mg to about 19.9 ng*hr/mL/mg (per mg hydrocodone bitartrate administered) and a Cmax for acetaminophen of between about 2.8 ng/mL/mg and 7.9 ng/mL/mg and an AUC for acetaminophen of between about 28.6 ng*hr/mL/mg and about 59.1 ng*hr/mL/mg (per mg acetaminophen administered) after a single dose.