Marie G Selzer, 836035 Bayview Dr, Fort Lauderdale, FL 33308

6429204, Aug 6, 2002

Apr 3, 2000

09/542402

Lorne M. Golub - Smithtown NY
Thomas F. McNamara - Morristown NY
Nungavaram S. Ramamurthy - Smithtown NY
Hsi-Ming Lee - Setauket NY
Sanford Simon - Stony Brook NY
Balakrishna L. Lokeshwar - Miami FL
Marie G. Selzer - Fort Lauderdale FL
Norman L. Block - Miami FL

University of Miami - Miami FL

A61K 3165

514152, 514153

The invention is a method of inhibiting a sarcoma, such as Kaposis sarcoma, in a mammal. The method employs 6-demethyl-6-deoxy-4-de(dimethylamino)tetracycline (CMT-3. ).

6455583, Sep 24, 2002

May 7, 1999

09/307182

Stephen C. Pflugfelder - Miami FL
Balakrishna L. Lokeshwar - Miami FL
Marie Selzer - Fort Lauderdale FL

The University of Miami - Miami FL

A01N 3734

514528, 514912

A method for treating a patient having meibomian gland disease, ocular irritation associated with delayed tear clearance, or recurrent corneal epithelial erosion, is disclosed. Preferably, the method concerns treatment of a patient with topical tetracycline, a derivative or analogue of tetracycline, or a chemically modified tetracycline (CMT). Oral administration of a CMT is also disclosed as part of the method for treating meibomian gland disease, ocular irritation associated with delayed tear clearance, or recurrent corneal epithelial erosion.

2003011, Jun 19, 2003

Aug 22, 2002

10/225341

Stephen Pflugfelder - Miami FL, US
Balakrishna Lokeshwar - Miami FL, US
Marie Selzer - Fort Lauderdale FL, US

A61K031/65

514/152000

A method for treating a patient having meibomian gland disease, ocular irritation associated with delayed tear clearance, or recurrent corneal epithelial erosion, is disclosed. Preferably, the method concerns treatment of a patient with topical tetracycline, a derivative or analogue of tetracycline, or a chemically modified tetracycline (CMT). Oral administration of a CMT is also disclosed as part of the method for treating meibomian gland disease, ocular irritation associated with delayed tear clearance, or recurrent corneal epithelial erosion.

2006015, Jul 13, 2006

Dec 7, 2005

11/297780

Stephen Pflugfelder - Miami FL, US
Balakrishna Lokeshwar - Miami FL, US
Marie Selzer - Fort Lauderdale FL, US

A61K 31/65

514152000

A method for treating a patient having meibomian gland disease, ocular irritation associated with delayed tear clearance, or recurrent corneal epithelial erosion, is disclosed. Preferably, the method concerns treatment of a patient with topical tetracycline, a derivative or analogue of tetracycline, or a chemically modified tetracycline (CMT). Oral administration of a CMT is also disclosed as part of the method for treating meibomian gland disease, ocular irritation associated with delayed tear clearance, or recurrent corneal epithelial erosion.

2008021, Sep 4, 2008

Oct 11, 2007

11/974435

Stephen C. PFLUGFELDER - Miami FL, US
Balakrishna L. LOKESHWAR - Miami FL, US
Marie SELZER - Fort Lauderdale FL, US

A61K 31/165
A61P 27/02

514152

A method for treating a patient having meibomian gland disease, ocular irritation associated with delayed tear clearance, or recurrent corneal epithelial erosion, is disclosed. Preferably, the method concerns treatment of a patient with topical tetracycline, a derivative or analogue of tetracycline, or a chemically modified tetracycline (CMT). Oral administration of a CMT is also disclosed as part of the method for treating meibomian gland disease, ocular irritation associated with delayed tear clearance, or recurrent corneal epithelial erosion.

2011003, Feb 17, 2011

Jul 21, 2010

12/841058

Stephen C. Pflugfelder - Miami FL, US
Balakrishna L. Lokeshwar - Miami FL, US
Marie Selzer - Fort Lauderdale FL, US

The University of Miami - Miami FL

A61K 31/65
A61P 27/02

514152

A method for treating a patient having meibomian gland disease, ocular irritation associated with delayed tear clearance, or recurrent corneal epithelial erosion, is disclosed. Preferably, the method concerns treatment of a patient with topical tetracycline, a derivative or analogue of tetracycline, or a chemically modified tetracycline (CMT). Oral administration of a CMT is also disclosed as part of the method for treating meibomian gland disease, ocular irritation associated with delayed tear clearance, or recurrent corneal epithelial erosion.

2012008, Apr 12, 2012

Dec 1, 2011

13/309145

Stephen C. Pflugfelder - Miami FL, US
Balakrishna L. Lokeshwar - Miami FL, US
Marie Selzer - Fort Lauderdale FL, US

THE UNIVERSITY OF MIAMI - Miami FL

A61K 31/65
A61P 31/00
A61P 27/02

514152

A method for treating a patient having meibomian gland disease, ocular irritation associated with delayed tear clearance, or recurrent corneal epithelial erosion, is disclosed. Preferably, the method concerns treatment of a patient with topical tetracycline, a derivative or analogue of tetracycline, or a chemically modified tetracycline (CMT). Oral administration of a CMT is also disclosed as part of the method for treating meibomian gland disease, ocular irritation associated with delayed tear clearance, or recurrent corneal epithelial erosion.

6100248, Aug 8, 2000

Jan 15, 1998

9/007645

Lorne M. Golub - Smithtown NY
Thomas F. McNamara - Port Jefferson NY
Nungavaram S. Ramamurthy - Smithtown NY
Hsi-Ming Lee - Setauket NY
Sanford Simon - Stony Brook NY
Balakrishna L. Lokeshwar - Miami FL
Marie G. Selzer - Fort Lauderdale FL
Norman L. Block - Miami FL

A01N 3718

514152

The invention is a method of inhibiting cancer growth, by inhibiting cellular proliferation, invasiveness, or metastasis, or by inducing cytotoxicity against cancer in mammals. The method employs 6-demethyl-6-deoxy-4-de(dimethylamino)tetracycline (CMT-3) and other functionally related chemically modified, preferably non-antibacterial, tetracycline compounds to inhibit cancer growth. The method is particularly effective to inhibit the establishment, growth, and metastasis of solid tumors, such as tumors derived from colon cancer cells, breast cancer cells, melanoma cells, prostatic carcinoma cells, or lung cancer cells.