Inventors:
P. Conn - Brentwood TN, US
Anthony DiLella - Lansdale PA, US
Gene Kinney - Collegeville PA, US
Michael Marino - Souderton PA, US
Guy Seabrook - Blue Bell PA, US
David Williams - Telford PA, US
International Classification:
A61K 31/5513
A61K 31/551
A61K 31/5415
A61K 31/553
A61K 31/198
A61K 31/445
A61K 31/48
US Classification:
514220000, 514221000, 514225800, 514284000, 514317000, 514567000, 514649000
Abstract:
An mGluR4 receptor positive allosteric modulator is useful, alone or in combination with a neuroleptic agent, for treating or preventing movement disorders such as Parkinson's disease, dyskinesia, tardive dyskinesia, drug-induced parkinsonism, postencephalitic parkinsonism, progressive supranuclear palsy, multiple system atrophy, corticobasal degeneration, parkinsonian-ALS dementia complex, basal ganglia calcification, akinesia, akinetic-rigid syndrome, bradykinesia, dystonia, medication-induced parkinsonian, Gilles de la Tourette syndrome, Huntington's disease, tremor, chorea, myoclonus, tick disorder, and dystonia.