Aparajita A Dutta, 51Graniteville, MA

7822249, Oct 26, 2010

Aug 24, 2007

11/895417

Guy Garty - Dobbs Ferry NY, US
David J. Brenner - New York NY, US
Gerhard Randers-Pehrson - Ossining NY, US
Y. Lawrence Yao - New York NY, US
Nabil Simaan - New York NY, US
Alessio Salerno - Montreal, CA
Anubha Bhatla - Secaucus NJ, US
Jian Zhang - New York NY, US
Oleksandra V. Lyulko - New York NY, US
Aparajita Dutta - Waltham MA, US

The Trustees of Columbia University in the City of New York - New York NY

G06K 9/00

382128

Systems and methods for high-throughput radiation biodosimetry are disclosed herein. In some embodiments, a high-throughput methods of analyzing a population for radiation exposure can include, in various possible sequences: marking a first capillary designed to retain a first sample from the population with a first identifier; transporting a plurality of samples to a biodosimetry system; inputting the samples into the biodosimetry system; centrifuging the plurality of samples including the first sample wherein each sample can be retained in a capillary and the first sample can be retained in the first capillary; transferring the plurality of capillaries including the first capillary from the centrifuge to a cutting device using a robotic device; cutting the first capillary; reading the first identifier; transferring at least one portion of the first sample from the first capillary to a well in an array, wherein the array can include one or more filters in a multi-well plate; correlating the first identifier to a location of the array that includes the at least one portion of the first sample; one or more cycles of biological processing, which can include addition of a reagent and/or incubation of a selected temperature such as, for example, 37 C. , 4 C. , room temperature, and the like; sealing the array; positioning the array adjacent to an imaging element; focusing the imaging element; capturing an image of the first sample in the array; and analyzing the image to determine whether the first sample indicates a level of radiation exposure exceeding a predetermined threshold.

2009005, Feb 26, 2009

Aug 24, 2007

11/895485

Jian Zhang - New York NY, US
Alessio Salerno - Montreal, CA
Nabil Simaan - New York NY, US
Y. Lawrence Yao - New York NY, US
Gerhard Randers-Pehrson - Ossining NY, US
Guy Garty - Dobbs Ferry NY, US
Aparajita Dutta - Waltham MA, US
David J. Brenner - New York NY, US

B04B 5/10

494 17, 494 37, 901 6

Systems and methods for robotic transport are disclosed herein. In some embodiments, robotic systems for transporting biological samples include: a plurality of capillary vessels, in which each capillary vessel can contain a biological sample from a population; a receptacle that can contain the plurality of capillary vessels; a centrifuge; a first robotic device that can transport the receptacle between an input module and the centrifuge; a second robotic device that can transport the receptacle between the centrifuge and a sample harvest location; a cutting device that can cut each of the plurality of capillary vessels; a multi-well plate having a plurality of wells arranged in an array; and a third robotic device that can transfer at least one portion of each of the plurality of biological samples from each of the plurality of capillary vessels to a corresponding well in the array.

2012013, May 31, 2012

Aug 24, 2007

11/895557

Anubha Bhatla - Secaucus NJ, US
Alessio Salerno - Montreal, CA
Nabil Simaan - New York NY, US
Y. Lawrence Yao - New York NY, US
Gerhard Randers-Pehrson - Ossining NY, US
Guy Y. Garty - Dobbs Ferry NY, US
Aparajita Dutta - Waltham MA, US
David J. Brenner - New York NY, US

B65B 3/26

141 1, 141 83

Systems and methods for cutting materials are disclosed herein In some embodiments, methods of at least partially severing a capillary vessel can include: focusing a laser on a predetermined point on the capillary vessel, said capillary vessel containing a biological sample; and cutting the capillary vessel using a laser at the predetermined point. In some embodiments, the methods further can include capturing an image of the capillary vessel and analyzing the image to determine the predetermined point. In some embodiments, a beam of the laser can be moved using one or more galvanometric mirrors. In some embodiments, the methods further can include cutting a plurality of capillary vessels using the laser. In some embodiments, the methods can include utilizing a plurality of lasers, and/or further can include rotating the capillary vessel while the laser can be cutting the capillary vessel. In some embodiments, cutting the capillary vessel can include cutting only a portion of the capillary vessel.