Aaron R Noyes, 45496 Swains Pond Ave, Melrose, MA 02176
Aaron Noyes Phones & Addresses
496 Swains Pond Ave, Melrose, MA 02176 781-6625451
84 East St, Pepperell, MA 01463
86 East St, Pepperell, MA 01463
69 Magazine St, Cambridge, MA 02139
Brookline, MA
Somerville, MA
108 Central St APT 3L, Somerville, MA 02143
Mentions for Aaron R Noyes
Publications & IP owners
Us Patents
System For Automated Compression Of Chromatography Columns
US Patent:
7238282, Jul 3, 2007
Filed:
Mar 4, 2005
Appl. No.:
11/072081
Inventors:
Jeremy Perreault - Leominster MA, US
Aaron Noyes - Cambridge MA, US
Mark Carroll - Londonderry NH, US
Aaron Noyes - Cambridge MA, US
Mark Carroll - Londonderry NH, US
Assignee:
Millipore Corporation - Billerica MA
International Classification:
B01D 15/08
US Classification:
2101982, 210656
Abstract:
The present invention provides an automated system and method for maintaining compaction, and therefore increased efficiency, of a media bed within a chromatography column. In the preferred embodiment, an adjustment assembly is slidingly engaged inside one end of the column such that it can be moved along the column's major axis. When idle, the force exerted on this end is equal to the compression on the media. When the column is actively processing chromatographic fluid, this exerted force can be expressed as the sum of the compression on the media, and the force of the fluid being processed. This total force and the fluid pressure are monitored using a load cell and a pressure sensor respectively. The compression force operating on the media bed is then computed based on these measurements and compared to the optimal value. The position of the adjustment assembly within the column is then modified in response to changes in the measured compression force.
Intelligent System And Method For Automated Packing Of Chromatography Columns
US Patent:
7435350, Oct 14, 2008
Filed:
Apr 4, 2005
Appl. No.:
11/098505
Inventors:
Aaron Noyes - Cambridge MA, US
Jeremy Perreault - Leominster MA, US
Mark Carroll - Londonderry NH, US
Jeremy Perreault - Leominster MA, US
Mark Carroll - Londonderry NH, US
Assignee:
Millipore Corporation - Billerica MA
International Classification:
B01D 15/08
US Classification:
210656, 2101982
Abstract:
The present invention provides an automated system and method for packing chromatography columns. In one embodiment, the system first determines the type of media that is present in the column, and uses this information to generate an automated procedure to pack the specific media type. In a second embodiment, the media type is made known to the system, such as via input from the operator. The system then uses this information, in the same manner as in the first embodiment, to generate an automated procedure to pack the specific media type. Finally, in a third embodiment, parameters such as column height and rate of compression are made known to the system, such as via input from the operator. The system then packs the column in accordance with these supplied parameters.
System For Automated Compression Of Chromatography Columns
US Patent:
7767090, Aug 3, 2010
Filed:
Nov 27, 2006
Appl. No.:
11/604458
Inventors:
Jeremy Perreault - Leominster MA, US
Aaron Noyes - Cambridge MA, US
Mark Carroll - Londonderry NH, US
Aaron Noyes - Cambridge MA, US
Mark Carroll - Londonderry NH, US
Assignee:
Millipore Corporation - Billerica MA
International Classification:
B01D 15/08
US Classification:
210656, 2101982
Abstract:
The present invention provides an automated system and method for maintaining compaction, and therefore increased efficiency, of a media bed within a chromatography column. In the preferred embodiment, an adjustment assembly is slidingly engaged inside one end of the column such that it can be moved along the column's major axis. When idle, the force exerted on this end is equal to the compression on the media. When the column is actively processing chromatographic fluid, this exerted force can be expressed as the sum of the compression on the media, and the force of the fluid being processed. This total force and the fluid pressure are monitored using a load cell and a pressure sensor respectively. The compression force operating on the media bed is then computed based on these measurements and compared to the optimal value. The position of the adjustment assembly within the column is then modified in response to changes in the measured compression force.
Intelligent System And Method For Automated Packing Of Chromatography Columns
US Patent:
8114295, Feb 14, 2012
Filed:
Sep 9, 2008
Appl. No.:
12/283016
Inventors:
Aaron Noyes - Cambridge MA, US
Jeremy Perreault - Leominster MA, US
Mark Carroll - Londonderry NH, US
Jeremy Perreault - Leominster MA, US
Mark Carroll - Londonderry NH, US
Assignee:
Millipore Corporation - Billerica MA
International Classification:
B01D 15/08
US Classification:
210656, 2101982
Abstract:
The present invention provides an automated system and method for packing chromatography columns. In one embodiment, the system first determines the type of media that is present in the column, and uses this information to generate an automated procedure to pack the specific media type. In a second embodiment, the media type is made known to the system, such as via input from the operator. The system then uses this information, in the same manner as in the first embodiment, to generate an automated procedure to pack the specific media type. Finally, in a third embodiment, parameters such as column height and rate of compression are made known to the system, such as via input from the operator. The system then packs the column in accordance with these supplied parameters.
System For Automated Compression Of Chromatography Columns
US Patent:
8591742, Nov 26, 2013
Filed:
Jun 18, 2010
Appl. No.:
12/818287
Inventors:
Jeremy Perreault - Leominster MA, US
Aaron Noyes - Cambridge MA, US
Mark Carroll - Londonderry NH, US
Aaron Noyes - Cambridge MA, US
Mark Carroll - Londonderry NH, US
Assignee:
EMD Millipore Corporation - Billerica MA
International Classification:
B01D 15/08
US Classification:
210656, 2101982
Abstract:
The present invention provides an automated system and method for maintaining compaction, and therefore increased efficiency, of a media bed within a chromatography column. In the preferred embodiment, an adjustment assembly is slidingly engaged inside one end of the column such that it can be moved along the column's major axis. When idle, the force exerted on this end is equal to the compression on the media. When the column is actively processing chromatographic fluid, this exerted force can be expressed as the sum of the compression on the media, and the force of the fluid being processed. This total force and the fluid pressure are monitored using a load cell and a pressure sensor respectively. The compression force operating on the media bed is then computed based on these measurements and compared to the optimal value. The position of the adjustment assembly within the column is then modified in response to changes in the measured compression force.
High Velocity Chromatography Column Flow Distributor
US Patent:
2004018, Sep 23, 2004
Filed:
Feb 17, 2004
Appl. No.:
10/779995
Inventors:
Michael Titus - Ayer MA, US
Aaron Noyes - Somerville MA, US
Ian Rayner - Waltham MA, US
Chris Antoniou - Chelmsford MA, US
Aaron Noyes - Somerville MA, US
Ian Rayner - Waltham MA, US
Chris Antoniou - Chelmsford MA, US
International Classification:
G01N030/02
US Classification:
422/070000
Abstract:
The present invention is a flow distributor and integral bed support for a chromatography column. The flow distributor has an outlet extending through it and a bottom face across which is secured a bed support. The bottom face has a series of ribs extending radially outward from a center portion of the face. The bed support is secured to the flow distributor about its outer periphery and this amount of available surface area of the flow distributor and/or face that is used to secure the bed support is less than about 10%. A distribution disk is arranged over the inlet and extends across from about 1 to about 30% of the flow distributor's surface area, ending just short of the inner edge of the ribs closest to the center point of the flow distributor face. This disk is mounted on two or more legs so as to be of substantially the same height as the ribs. The disk projects the fluid flow in a 360 radial distribution without any noticeable partitioning. The flow distributor allows one to run the column at higher velocities up to 1500 cm/hour while maintaining its integrity and a standard flow across the flow distributor and while having a low-pressure drop across the column.
Methods Of Purifying Small Modular Immunopharmaceutical Proteins
US Patent:
2012014, Jun 7, 2012
Filed:
Mar 11, 2010
Appl. No.:
13/255650
Inventors:
Christopher John Gallo - Windham NH, US
Shujun Sun - Brentwood NH, US
James Edward Booth - Andover MA, US
Jason Richard Cormier - Westford MA, US
Daniel Patrick Lacasse - Leominister MA, US
Aaron Russell Noyes - Pepperell MA, US
Shujun Sun - Brentwood NH, US
James Edward Booth - Andover MA, US
Jason Richard Cormier - Westford MA, US
Daniel Patrick Lacasse - Leominister MA, US
Aaron Russell Noyes - Pepperell MA, US
Assignee:
Wyeth LLC - Madison NJ
International Classification:
A61K 39/395
C07K 16/28
C07K 1/18
C07K 1/16
C07K 1/22
C07K 16/28
C07K 1/18
C07K 1/16
C07K 1/22
US Classification:
4241581, 5303892
Abstract:
The present invention provides, among other things, methods of purifying or recovering proteins, in particular, small modular immunopharmaceutical (SMIPs™) proteins, from protein preparations containing high molecular weight (HMW) aggregates and other impurities based on hydroxyapatite chromatography. In some embodiments, the hydroxyapatite chromatography is used in combination with affinity chromatography and/or ion exchange chromatography. In some embodiments, inventive methods according to the invention involve no more than three chromatography steps. The present invention also provides proteins such as SMIPs™ purified according to the invention and pharmaceutical compositions containing the same.
High-Throughput Chromatography Screening For Extracellular Vesicles
US Patent:
2022039, Dec 8, 2022
Filed:
Nov 5, 2020
Appl. No.:
17/774774
Inventors:
- Cambridge, MA
Aaron NOYES - Melrose MA, US
Andrew WOOD - Concord MA, US
Aaron NOYES - Melrose MA, US
Andrew WOOD - Concord MA, US
Assignee:
Codiak BioSciences, Inc. - Cambridge MA
International Classification:
G01N 33/50
B01D 15/38
G01N 21/49
G01N 21/64
B01D 15/38
G01N 21/49
G01N 21/64
Abstract:
The present disclosure relates to high-throughput screening methods for identifying one or more chromatography operational parameters (e.g., binding parameters) and/or reagents for purifying EVs (e.g., exosomes) from a sample using chromatography. Also disclosed herein are methods for improving one or more aspects of EV (e.g., exosome) purification, e.g., improving EV yield, increasing EV ligand density, and/or reducing impurity recovery.
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