Arthur K Field, 873121 Twin Silo Dr, Blue Bell, PA 19422

4124702, Nov 7, 1978

Dec 14, 1976

5/750499

George P. Lampson - Hatfield PA
Alfred A. Tytell - Lansdale PA
Arthur K. Field - North Wales PA
Maurice R. Hilleman - Lafayette Hill PA

Merck & Co., Inc. - Rahway NJ

A61K 4504

424 85

Polynucleotides which are multistranded are active as inducers of interferon production in living animal cells. They may be: A. Synthetically complexed polymers of two homopolynucleotides. B. A nucleic acid released by phenol from a ribonucleic acid complex elaborated by the growth of Penicillium funiculosum. C. A ribonucleic acid from reovirus type 3 virions. D. Replicative forms of nucleic acids.

4283393, Aug 11, 1981

Mar 13, 1979

6/020125

Arthur K. Field - North Wales PA
Richard J. Harwood - Philadelphia PA

Merck & Co., Inc. - Rahway NJ

A61K 3170

424180

Virus infections of eye, skin and mucous membrane tissue are effectively treated by controlled release topical application of interferon inducers.

4816447, Mar 28, 1989

Jun 6, 1984

6/617868

Wallace T. Ashton - Clark NJ
Arthur K. Field - North Wales PA
John D. Karkas - New York NY
Richard L. Tolman - Warren NJ

Merck & Co., Inc. - Rahway NJ

C07D47318
A61K 3152

514 81

9-(1,3-Dihydroxy-2-propoxymethyl)guanine and 9-(2,3-dihydroxy-1-propoxymethyl)guanine have been found to have potent anti-viral activity against herpes viruses. These compounds, their acyl derivatives, their phosphate derivatives and their pharmaceutically acceptable salts, pharmaceutical formulations containing these compounds, the treatment of DNA viral or herpes viral infections with these compounds, method of preparing these compounds, and novel intermediates useful in their preparation are all disclosed. The compounds may be prepared by reaction of the appropriate acetoxymethyl ether with diacetylguanine, followed by deprotection. The acetoxymethyl ethers may be obtained by reaction of glycerol formal with acetic anhydride in the presence of a catalyst.

4198479, Apr 15, 1980

Mar 30, 1979

6/025305

Alfred A. Tytell - Lansdale PA
Edgar Scattergood - Lansdale PA
Arthur K. Field - North Wales PA

Merck & Co., Inc. - Rahway NJ

A61N 102
A61K 4502

435 2

The invention provides an improved process for the growth of lymphoblastoid cells in a medium supplemented with human albumin. The invention further provides for the production of interferon by viral infection of these lymphoblastoid cells in a medium also supplemented with human albumin. This invention eliminates the necessity for adding animal proteins.

4880820, Nov 14, 1989

Feb 8, 1988

7/150478

Wallace T. Ashton - Clark NJ
Laura F. Canning - Clark NJ
Arthur K. Field - North Wales PA
Richard L. Tolman - Warren NJ

Merck & Co., Inc. - Rahway NJ

C07D47318
A61K 3152

514322

(S)-9-(2,3-dihydroxy-1-propoxymethyl)guanine has potent antiherpetic activity which is superior to the corresponding racemic mixture or the (R)-enantiomer and also is much more potent than 9-(2-hydroxyethoxymethyl)guanine. Acyl derivatives (prodrugs) of the (S)-enantiomer, which are more effective than the corresponding (R)-enantiomer analogs or related racemic mixtures provide formulation advantages and even higher plasma half lives in animals or man than the (S)-isomer.