BackgroundCheck.run
Search For

Ashok K Gupta, 77Fort Mill, SC

Ashok Gupta Phones & Addresses

Fort Mill, SC   

11710 Old Georgetown Rd #1102, Rockville, MD 20852    301-8417493   

11710 Old Georgetown Rd #305, Rockville, MD 20852    248-3442599   

45315 Courtview Trl, Novi, MI 48375    248-3442599    248-3482844   

Macomb, MI   

Elizabeth, NJ   

Canton, MI   

Dayton, MD   

Forest Hills, NY   

Work

Company: Retired from govt of india, worked in a n go for consumer affairs - New Delhi, Delhi Jul 2010 Position: Audit and accounts consultancy

Education

School / High School: Agra College Agra- Agra, Uttar Pradesh 1967 Specialities: B. Sc.Biology in Science n Law

Mentions for Ashok K Gupta

Career records & work history

Medicine Doctors

Ashok Gupta Photo 1

Dr. Ashok K Gupta, Sylvan Lake MI - MD (Doctor of Medicine)

Specialties:
Internal Medicine
Geriatric Medicine
Address:
DR ASHOK GUPTA M.D.
2111 Orchard Lake Rd, Sylvan Lake, MI 48320
248-6816577 (Phone)
Procedures:
Diabetes Care
Hypertension (High Blood Pressure)
Weight Loss
Conditions:
Diabetes Mellitus
Certifications:
Internal Medicine
Awards:
Healthgrades Honor Roll
Languages:
English
Hindi
Hospitals:
DR ASHOK GUPTA M.D.
2111 Orchard Lake Rd, Sylvan Lake, MI 48320
Doctors' Hospital of Michigan
461 West Huron Street, Pontiac, MI 48341
St. Joseph Mercy Oakland
44405 Woodward Avenue, Pontiac, MI 48341
Philosophy:
Promote walking
Education:
Medical School
Government Medical College Patiala
Graduated: 1972
Medical School
St Joseph Mercy Oakland Pontiac
Graduated: 1980
Medical School
St Joseph Mercy Hosp Oakland
Graduated: 1982
Medical School
D a V College Ambala City
Graduated: 1967
Ashok Gupta Photo 2

Ashok K Gupta, Madison Heights MI

Specialties:
Cardiology
Interventional Cardiology
Address:
MADISON CARDIOLOGY
610 E 12 Mile Rd, Madison Heights, MI 48071
248-5899111 (Phone) 248-5419113 (Fax)
Certifications:
Cardiovascular Disease, 1981
Internal Medicine, 1979
Interventional Cardiology, 1999
Awards:
Healthgrades Honor Roll
Languages:
English
Hindi
Hospitals:
DR ASHOK GUPTA M.D.
2111 Orchard Lake Rd, Sylvan Lake, MI 48320
Doctors' Hospital of Michigan
461 West Huron Street, Pontiac, MI 48341
St. Joseph Mercy Oakland
44405 Woodward Avenue, Pontiac, MI 48341
MADISON CARDIOLOGY
610 E 12 Mile Rd, Madison Heights, MI 48071
Beaumont Hospital - Royal Oak
3601 West 13 Mile Road, Royal Oak, MI 48073
Saint John Macomb - Oakland Hospital - Oakland Center
27351 Dequindre Road, Madison Heights, MI 48071
Education:
Medical School
Guru Nanak Dev University
Medical School
Sinai Grace Hospital
Medical School
Chicago Med Sch Affil Hosp
Medical School
Cook Co Hosp
Medical School
Sj Meml Hosp
Ashok Gupta Photo 3

Dr. Ashok K Gupta, Dearborn MI - MD (Doctor of Medicine)

Specialties:
Internal Medicine
Address:
Henry Ford Medical Group
19401 Hubbard Dr, Dearborn, MI 48126
313-9828100 (Phone)
Ashok K Gupta MD
2200 Beechmont St, Keego Harbor, MI 48320
248-6816577 (Phone)
Languages:
English

Ashok Gupta

Specialties:
Gastroenterology, Internal Medicine
Work:
Ashok Gupta MD
842 Clifton Ave STE 6, Clifton, NJ 07013
973-4700101 (phone) 973-7773024 (fax)
Gastroenterology Diagnostics Of Northern New Jersey
205 Browertown Rd STE 102, Little Falls, NJ 07424
973-8904780 (phone) 973-8901097 (fax)
Education:
Medical School
Gov't Med Coll, Baba Farid Univ Hlth Sci, Patiala, Punjab, India
Graduated: 1973
Procedures:
Endoscopic Retrograde Cholangiopancreatography (ERCP), Colonoscopy, Electrocardiogram (EKG or ECG), Sigmoidoscopy, Upper Gastrointestinal Endoscopy, Vaccine Administration
Conditions:
Cholelethiasis or Cholecystitis, Diverticulosis, Gastrointestinal Hemorrhage, Intestinal Obstruction, Ischemic Bowel Disease, Malignant Neoplasm of Colon, Pancreatic Cancer, Peptic Ulcer Disease, Abdominal Aortic Aneurysm, Abdominal Hernia, Acne, Acute Bronchitis, Acute Myocardial Infarction (AMI), Acute Pancreatitis, Acute Renal Failure, Acute Sinusitis, Acute Upper Respiratory Tract Infections, Anal Fissure, Anal or Rectal Abscess, Anemia, Anxiety Phobic Disorders, Aortic Aneurism, Aortic Valvular Disease, Appendicitis, Arterial Thromboembolic Disease, Atopic Dermatitis, Atrial Fibrillation and Atrial Flutter, Bacterial Food Poisoning, Benign Paroxysmal Positional Vertigo, Benign Polyps of the Colon, Benign Prostatic Hypertrophy, Bipolar Disorder, Bronchial Asthma, Calculus of the Urinary System, Candidiasis, Cardiac Arrhythmia, Cardiomyopathy, Celiac Disease, Chronic Bronchitis, Chronic Pancreatitis, Chronic Renal Disease, Cirrhosis, Conduction Disorders, Constipation, Contact Dermatitis, Dehydration, Dementia, Dermatitis, Diabetes Mellitus (DM), Disorders of Lipoid Metabolism, Diverticulitis, Endocarditis, Epilepsy, Esophagitis, Fractures, Dislocations, Derangement, and Sprains, Gastric Cancer, Gastritis and Duodenitis, Gastroesophageal Reflux Disease (GERD), Heart Failure, Hemorrhagic stroke, Hemorrhoids, Herpes Simplex, Herpes Zoster, HIV Infection, Hypertension (HTN), Hyperthyroidism, Hypothyroidism, Infectious Liver Disease, Infectious Mononucleosis, Inflammatory Bowel Disease (IBD), Inguinal Hernia, Intervertebral Disc Degeneration, Intussusception, Iron Deficiency Anemia, Irritable Bowel Syndrome (IBS), Ischemic Heart Disease, Ischemic Stroke, Liver Cancer, Lyme Disease, Macular Degeneration, Malignant Neoplasm of Esophagus, Malignant Neoplasm of Female Breast, Multiple Sclerosis (MS), Myasthenia Gravis (MG), Non-Toxic Goiter, Obstructive Sleep Apnea, Osteoarthritis, Osteoporosis, Otitis Media, Overweight and Obesity, Parkinson's Disease, Peripheral Nerve Disorders, Pneumonia, Poisoning by Drugs, Meds, or Biological Substances, Polycystic Ovarian Syndrome (PCOS), Psoriasis, Pulmonary Embolism, Rectal, Abdomen, Small Intestines, or Colon Cancer, Restless Leg Syndrome, Rheumatoid Arthritis, Sarcoidosis, Schizophrenia, Septicemia, Skin and Subcutaneous Infections, Spinal Stenosis, Substance Abuse and/or Dependency, Systemic Lupus Erythematosus, Transient Cerebral Ischemia, Urinary Tract Infection (UT), Varicose Veins, Venous Embolism and Thrombosis, Ventral Hernia, Vitamin B12 Deficiency Anemia, Vitamin D Deficiency
Languages:
English
Description:
Dr. Gupta graduated from the Gov't Med Coll, Baba Farid Univ Hlth Sci, Patiala, Punjab, India in 1973. He works in Clifton, NJ and 1 other location and specializes in Gastroenterology and Internal Medicine. Dr. Gupta is affiliated with Chilton Medical Center, Saint Marys General Hospital, St Josephs Regional Medical Center and St Josephs Wayne Hospital.

Ashok K. Gupta

Specialties:
Internal Medicine, Sleep Medicine
Work:
Family Care Center
101 E Spicerville Hwy, Eaton Rapids, MI 48827
517-6632705 (phone) 517-6639470 (fax)
Life Care Sleep & Health Center
7200 W Saginaw Hwy STE 2, Lansing, MI 48917
517-3239624 (phone) 517-3239634 (fax)
Midwest Center For Sleep Disorders
3937 Patient Care Dr STE 102, Lansing, MI 48911
517-8876733 (phone) 517-8876736 (fax)
Education:
Medical School
Gov't Med Coll, Guru Nanak Dev Univ, Amritsar, Punjab, India
Graduated: 1975
Procedures:
Allergen Immunotherapy, Arthrocentesis, Cardiac Stress Test, Continuous EKG, Destruction of Benign/Premalignant Skin Lesions, Electrocardiogram (EKG or ECG), Skin Tags Removal, Vaccine Administration
Conditions:
Abnormal Vaginal Bleeding, Acute Myocardial Infarction (AMI), Acute Pancreatitis, Acute Pharyngitis, Acute Sinusitis, Acute Upper Respiratory Tract Infections, Anemia, Atrial Fibrillation and Atrial Flutter, Benign Prostatic Hypertrophy, Bronchial Asthma, Chronic Bronchitis, Contact Dermatitis, Dementia, Disorders of Lipoid Metabolism, Diverticulitis, Erectile Dysfunction (ED), Fractures, Dislocations, Derangement, and Sprains, Gastroesophageal Reflux Disease (GERD), Gout, Heart Failure, Hemorrhoids, Herpes Zoster, Hypertension (HTN), Hypothyroidism, Insomnia, Intestinal Obstruction, Ischemic Heart Disease, Ischemic Stroke, Migraine Headache, Obstructive Sleep Apnea, Osteoarthritis, Osteoporosis, Otitis Media, Plantar Warts, Pneumonia, Restless Leg Syndrome, Rheumatoid Arthritis, Skin and Subcutaneous Infections, Urinary Tract Infection (UT), Vitamin D Deficiency, Acne, Acute Bronchitis, Acute Conjunctivitis, Acute Glomerulonephritis, Alcohol Dependence, Alzheimer's Disease, Anal Fissure, Anxiety Phobic Disorders, Appendicitis, Atherosclerosis, Atopic Dermatitis, Attention Deficit Disorder (ADD), Autism, Bell's Palsy, Benign Thyroid Diseases, Bipolar Disorder, Burns, Calculus of the Urinary System, Candidiasis, Candidiasis of Vulva and Vagina, Cardiac Arrhythmia, Cardiomyopathy, Carpel Tunnel Syndrome, Cholelethiasis or Cholecystitis, Chronic Fatigue Syndrome, Chronic Renal Disease, Cirrhosis, Conduction Disorders, Constipation, Dehydration, Dermatitis, Diabetes Mellitus (DM), Diverticulosis, Eating Disorders, Endocarditis, Gastritis and Duodenitis, Gastrointestinal Hemorrhage, Gingival and Periodontal Diseases, Glaucoma, Hearing Loss, Herpes Genitalis, Herpes Simplex, Hyperthyroidism, Infectious Liver Disease, Infectious Mononucleosis, Inflammatory Bowel Disease (IBD), Inguinal Hernia, Internal Derangement of Knee Cartilage, Intervertebral Disc Degeneration, Intracranial Injury, Iron Deficiency Anemia, Irritable Bowel Syndrome (IBS), Keratitis, Labyrinthitis, Lateral Epicondylitis, Malignant Neoplasm of Female Breast, Menopausal and Postmenopausal Disorders, Multiple Sclerosis (MS), Non-Toxic Goiter, Overweight and Obesity, Parkinson's Disease, Paroxysmal Supreventricular Tachycardia (PSVT), Peptic Ulcer Disease, Peripheral Nerve Disorders, Phlebitis and Thrombophlebitis, Plantar Fascitis, Polycystic Ovarian Syndrome (PCOS), Post Traumatic Stress Disorder (PTSD), Prostatitis, Psoriasis, Pulmonary Embolism, Rosacea, Sarcoidosis, Schizophrenia, Sciatica, Skin Cancer, Substance Abuse and/or Dependency, Sunburn, Systemic Lupus Erythematosus, Tension Headache, Thyroid Cancer, Tinea Pedis, Tinea Unguium, Transient Cerebral Ischemia, Urinary Incontinence, Varicose Veins, Venous Embolism and Thrombosis, Viral Meningitis
Languages:
English
Description:
Dr. Gupta graduated from the Gov't Med Coll, Guru Nanak Dev Univ, Amritsar, Punjab, India in 1975. He works in Lansing, MI and 2 other locations and specializes in Internal Medicine and Sleep Medicine. Dr. Gupta is affiliated with Eaton Rapids Medical Center, Mclaren Orthopedic Hospital and Sparrow Hospital.

Ashok K. Gupta

Specialties:
Internal Medicine, Internal Medicine - Geriatrics
Work:
Henry Ford Medical GroupAshok K Gupta MD
2111 Orch Lk Rd, Keego Harbor, MI 48320
248-6816577 (phone) 248-7327136 (fax)
Site
Education:
Medical School
Gov't Med Coll, Baba Farid Univ Hlth Sci, Patiala, Punjab, India
Graduated: 1972
Languages:
English, Spanish
Description:
Dr. Gupta graduated from the Gov't Med Coll, Baba Farid Univ Hlth Sci, Patiala, Punjab, India in 1972. He works in Sylvan Lake, MI and specializes in Internal Medicine and Internal Medicine - Geriatrics. Dr. Gupta is affiliated with Doctors Hospital Of Michigan.

Ashok K. Gupta

Specialties:
Diagnostic Radiology
Work:
Desert Radiologists
3920 S Eastern Ave STE 100, Las Vegas, NV 89119
702-7598600 (phone) 702-5983439 (fax)
Site
Desert Radiologists
2020 Palomino Ln STE 100, Las Vegas, NV 89106
702-7598700 (phone) 702-5983400 (fax)
Site
Desert Radiologists
2811 W Horizon Rdg Pkwy, Henderson, NV 89052
702-7594500 (phone) 702-6161069 (fax)
Site
Education:
Medical School
University of Nebraska College of Medicine
Graduated: 1996
Languages:
English
Description:
Dr. Gupta graduated from the University of Nebraska College of Medicine in 1996. He works in Las Vegas, NV and 2 other locations and specializes in Diagnostic Radiology. Dr. Gupta is affiliated with Desert Springs Hospital Medical Center, Spring Valley Hospital Medical Center, Summerlin Hospital Medical Center, University Medical Center Of Southern Nevada and Valley Hospital Medical Center.

Ashok Gupta

Specialties:
Internal Medicine
Work:
Henry Ford Medical GroupHenry Ford Medical Center Fairlane
19401 Hubbard Dr, Dearborn, MI 48126
313-9828100 (phone) 313-9828205 (fax)
Site
Education:
Medical School
M.g.m. Med Coll, Devi Ahilya Vishwavidhyalaya, Indore, Mp, India
Graduated: 1975
Languages:
English, Spanish
Description:
Dr. Gupta graduated from the M.g.m. Med Coll, Devi Ahilya Vishwavidhyalaya, Indore, Mp, India in 1975. He works in Dearborn, MI and specializes in Internal Medicine. Dr. Gupta is affiliated with Henry Ford Hospital, Henry Ford Macomb Hospital, Henry Ford West Bloomfield Hospital and Henry Ford Wyandotte Hospital.

License Records

Ashok Kumar Gupta Md

Licenses:
License #: 3484 - Expired
Category: Medicine
Issued Date: Jun 20, 1996
Effective Date: Jun 30, 1997
Type: Temporary Educational Permit

Ashok K Gupta

Address:
11710 Old Georgetown Rd #1102, Rockville, MD 20852
Licenses:
License #: 72126 - Expired
Category: Engineers
Issued Date: Dec 27, 2010
Effective Date: Mar 14, 2017
Expiration Date: Feb 28, 2017
Type: Professional Engineer

Ashok Gupta resumes & CV records

Resumes

Ashok Gupta Photo 42

Chief, Receiving & Inspection Officer At United Nations Peace Keeping Mission

Position:
Chief, Receiving & Inspection Officer at United Nations Peace keeping Mission
Location:
Cote D'Ivoire (Ivory Coast)
Industry:
Nonprofit Organization Management
Work:
United Nations Peace keeping Mission
Chief, Receiving & Inspection Officer
Ashok Gupta Photo 43

Ashok Gupta

Location:
United States
Ashok Gupta Photo 44

Ashok Gupta

Location:
United States
Ashok Gupta Photo 45

Ashok Gupta - New, KY

Work:
retired from govt of India, worked in a N GO for consumer affairs - New Delhi, Delhi Jul 2010 to Present
audit and accounts consultancy
Education:
Agra College Agra - Agra, Uttar Pradesh 1967 to 1970
B. Sc.Biology in Science n Law

Publications & IP owners

Us Patents

Anti-Pd-L1 Antibody Treatment Of Bladder Cancer

US Patent:
2022033, Oct 20, 2022
Filed:
Apr 14, 2022
Appl. No.:
17/720903
Inventors:
- GAITHERSBURG MD, US
JOHN ANDREW BLAKE-HASKINS - GAITHERSBURG MD, US
MAGDALENA ZAJAC - CAMBRIDGE, GB
MARLON REBELATTO - GAITHERSBURG MD, US
ASHOK GUPTA - GAITHERSBURG MD, US
TONY HO - GAITHERSBURG MD, US
JILL WALKER - CAMBRIDGE, GB
XIAOPING JIN - GAITHERSBURG MD, US
SHANNON MORRIS - GAITHERSBURG MD, US
ROBERT IANNONE - GAITHERSBURG MD, US
LI SHI - GAITHERSBURG MD, US
MOHAMMED DAR - GAITHERSBURG MD, US
YONG BEN - GAITHERSBURG MD, US
International Classification:
C07K 16/28
A61P 35/00
A61K 9/00
G01N 33/542
Abstract:
Provided are methods of treating bladder cancer (e.g., urothelial carcinoma, UC) in a subject having bladder cancer, e.g., UC, with an effective dose regimen of an anti-PD-L1 antibody, e.g., durvalumab, or an antigen binding fragment thereof. Also provided are methods in which an anti-PD-L1 antibody is used in combination with another immunotherapeutic agent, e.g., tremelimumab to treat a bladder cancer, e.g., UC, in a subject having bladder cancer. In some cases, the subject undergoing treatment is identified as having a bladder cancer or tumor that is PD-L1-low/neg, or PD-L1-high. Methods are also provided in which anti-PD-L1 antibody treatment of bladder cancer is used following a standard of care or first-line therapy in subjects who have progressed following such therapies or who have relapsed after a prior treatment regimen.

Cancer Immunotherapy By Disrupting Pd-1/Pd-L1 Signaling

US Patent:
2020030, Oct 1, 2020
Filed:
Mar 23, 2020
Appl. No.:
16/827580
Inventors:
- Princeton NJ, US
Stacie M. Goldberg - Potomac MD, US
Ashok K. Gupta - Clarksburg MD, US
Xi-Tao Wang - Wellesley MA, US
Jon M. Wigginton - Collegeville PA, US
Assignee:
Bristol-Myers Squibb Company - Princeton NJ
International Classification:
C07K 16/28
A61K 39/395
C07K 16/18
G01N 33/574
Abstract:
The disclosure provides a method for immunotherapy of a subject afflicted with cancer, comprises administering to the subject a composition comprising a therapeutically effective amount of an antibody that inhibits signaling from the PD-1/PD-L1 signaling pathway. This disclosure also provides a method for immunotherapy of a subject afflicted with cancer comprising selecting a subject that is a suitable candidate for immunotherapy based on an assessment that the proportion of cells in a test tissue sample from the subject that express PD-L1 on the cell surface exceeds a predetermined threshold level, and administering a therapeutically effective amount of an anti-PD-1 antibody to the selected subject. The invention additionally provides rabbit mAbs that bind specifically to a cell surface-expressed PD-L1 antigen in a FFPE tissue sample, and an automated IHC method for assessing cell surface expression in FFPE tissues using the provided anti-PD-L1 Abs.

Anti-Pd-L1 Antibody Treatment Of Bladder Cancer

US Patent:
2019035, Nov 28, 2019
Filed:
Feb 16, 2018
Appl. No.:
16/486222
Inventors:
- GAITHERSBURG MD, US
JOHN ANDREW BLAKE-HASKINS - GAITHERSBURG MD, US
MAGDALENA ZAJAC - CAMBRIDGE, GB
MARLON REBELATTO - GAITHERSBURG MD, US
ASHOK GUPTA - GAITHERSBURG MD, US
TONY HO - GAITHERSBURG MD, US
JILL WALKER - CAMBRIDGE, GB
XIAOPING JIN - GAITHERSBURG MD, US
SHANNON MORRIS - GAITHERSBURG MD, US
ROBERT IANNONE - GAITHERSBURG MD, US
LI SHI - GAITHERSBURG MD, US
MOHAMMED DAR - GAITHERSBURG MD, US
YONG BEN - GAITHERSBURG MD, US
International Classification:
C07K 16/28
A61K 9/00
G01N 33/542
A61P 35/00
Abstract:
Provided are methods of treating bladder cancer (e.g., urothelial carcinoma, UC) in a subject having bladder cancer, e.g., UC, with an effective dose regimen of an anti-PD-L1 antibody, e.g., durvalumab, or an antigen binding fragment thereof. Also provided are methods in which an anti-PD-L1 antibody is used in combination with another immunotherapeutic agent, e.g., tremelimumab to treat a bladder cancer, e.g., UC, in a subject having bladder cancer. In some cases, the subject undergoing treatment is identified as having a bladder cancer or tumor that is PD-L1-low/neg, or PD-L1-high. Methods are also provided in which anti-PD-L1 antibody treatment of bladder cancer is used following a standard of care or first-line therapy in subjects who have progressed following such therapies or who have relapsed after a prior treatment regimen.

Cancer Immunotherapy By Disrupting Pd-1/Pd-L1 Signaling

US Patent:
2019015, May 23, 2019
Filed:
Jan 15, 2019
Appl. No.:
16/248215
Inventors:
- Princeton NJ, US
Stacie M. Goldberg - Potomac MD, US
Ashok K. Gupta - Clarksburg MD, US
Xi-Tao Wang - Wellesley MA, US
Jon M. Wigginton - Collegeville PA, US
Assignee:
Bristol-Myers Squibb Company - Princeton NJ
International Classification:
C07K 16/28
A61K 39/395
C07K 16/18
G01N 33/574
Abstract:
The disclosure provides a method for immunotherapy of a subject afflicted with cancer, comprises administering to the subject a composition comprising a therapeutically effective amount of an antibody that inhibits signaling from the PD-1/PD-L1 signaling pathway. This disclosure also provides a method for immunotherapy of a subject afflicted with cancer comprising selecting a subject that is a suitable candidate for immunotherapy based on an assessment that the proportion of cells in a test tissue sample from the subject that express PD-L1 on the cell surface exceeds a predetermined threshold level, and administering a therapeutically effective amount of an anti-PD-1 antibody to the selected subject. The invention additionally provides rabbit mAbs that bind specifically to a cell surface-expressed PD-L1 antigen in a FFPE tissue sample, and an automated IHC method for assessing cell surface expression in FFPE tissues using the provided anti-PD-L1 Abs.

Cancer Immunotherapy By Disrupting Pd-1/Pd-L1 Signaling

US Patent:
2019011, Apr 18, 2019
Filed:
Dec 21, 2018
Appl. No.:
16/230657
Inventors:
- Princeton NJ, US
Stacie M. Goldberg - Potomac MD, US
Ashok K. Gupta - Clarksburg MD, US
Xi-Tao Wang - Wellesley MA, US
Jon M. Wigginton - Collegeville PA, US
Assignee:
Bristol-Myers Squibb Company - Princeton NJ
International Classification:
C07K 16/28
A61K 39/395
C07K 16/18
G01N 33/574
Abstract:
The disclosure provides a method for immunotherapy of a subject afflicted with cancer, comprises administering to the subject a composition comprising a therapeutically effective amount of an antibody that inhibits signaling from the PD-1/PD-L1 signaling pathway. This disclosure also provides a method for immunotherapy of a subject afflicted with cancer comprising selecting a subject that is a suitable candidate for immunotherapy based on an assessment that the proportion of cells in a test tissue sample from the subject that express PD-L1 on the cell surface exceeds a predetermined threshold level, and administering a therapeutically effective amount of an anti-PD-1 antibody to the selected subject. The invention additionally provides rabbit mAbs that bind specifically to a cell surface-expressed PD-L1 antigen in a FFPE tissue sample, and an automated IHC method for assessing cell surface expression in FFPE tissues using the provided anti-PD-L1 Abs.

Cancer Immunotherapy By Disrupting Pd-1/Pd-L1 Signaling

US Patent:
2019011, Apr 18, 2019
Filed:
Dec 21, 2018
Appl. No.:
16/231211
Inventors:
- Princeton NJ, US
Stacie M. Goldberg - Potomac MD, US
Ashok K. Gupta - Clarksburg MD, US
Xi-Tao Wang - Wellesley MA, US
Jon M. Wigginton - Collegeville PA, US
Assignee:
Bristol-Myers Squibb Company - Princeton NJ
International Classification:
C07K 16/28
A61K 39/395
C07K 16/18
G01N 33/574
Abstract:
The disclosure provides a method for immunotherapy of a subject afflicted with cancer, comprises administering to the subject a composition comprising a therapeutically effective amount of an antibody that inhibits signaling from the PD-1/PD-L1 signaling pathway. This disclosure also provides a method for immunotherapy of a subject afflicted with cancer comprising selecting a subject that is a suitable candidate for immunotherapy based on an assessment that the proportion of cells in a test tissue sample from the subject that express PD-L1 on the cell surface exceeds a predetermined threshold level, and administering a therapeutically effective amount of an anti-PD-1 antibody to the selected subject. The invention additionally provides rabbit mAbs that bind specifically to a cell surface-expressed PD-L1 antigen in a FFPE tissue sample, and an automated IHC method for assessing cell surface expression in FFPE tissues using the provided anti-PD-L1 Abs.

Cancer Immunotherapy By Disrupting Pd-1/Pd-L1 Signaling

US Patent:
2019010, Apr 4, 2019
Filed:
Dec 7, 2018
Appl. No.:
16/213954
Inventors:
- Princeton NJ, US
Stacie M. Goldberg - Potomac MD, US
Ashok K. Gupta - Clarksburg MD, US
Xi-Tao Wang - Wellesley MA, US
Jon M. Wigginton - Collegeville PA, US
Assignee:
Bristol-Myers Squibb Company - Princeton NJ
International Classification:
C07K 16/28
G01N 33/574
C07K 16/18
A61K 39/395
Abstract:
The disclosure provides a method for immunotherapy of a subject afflicted with cancer, comprises administering to the subject a composition comprising a therapeutically effective amount of an antibody that inhibits signaling from the PD-1/PD-L1 signaling pathway. This disclosure also provides a method for immunotherapy of a subject afflicted with cancer comprising selecting a subject that is a suitable candidate for immunotherapy based on an assessment that the proportion of cells in a test tissue sample from the subject that express PD-L1 on the cell surface exceeds a predetermined threshold level, and administering a therapeutically effective amount of an anti-PD-1 antibody to the selected subject. The invention additionally provides rabbit mAbs that bind specifically to a cell surface-expressed PD-L1 antigen in a FFPE tissue sample, and an automated IHC method for assessing cell surface expression in FFPE tissues using the provided anti-PD-L1 Abs.

Cancer Immunotherapy By Disrupting Pd-1/Pd-L1 Signaling

US Patent:
2019010, Apr 4, 2019
Filed:
Dec 7, 2018
Appl. No.:
16/213965
Inventors:
- Princeton NJ, US
Stacie M. Goldberg - Potomac MD, US
Ashok K. Gupta - Clarksburg MD, US
Xi-Tao Wang - Wellesley MA, US
Jon M. Wigginton - Collegeville PA, US
Assignee:
Bristol-Myers Squibb Company - Princeton NJ
International Classification:
C07K 16/28
G01N 33/574
C07K 16/18
A61K 39/395
Abstract:
The disclosure provides a method for immunotherapy of a subject afflicted with cancer, comprises administering to the subject a composition comprising a therapeutically effective amount of an antibody that inhibits signaling from the PD-1/PD-L1 signaling pathway. This disclosure also provides a method for immunotherapy of a subject afflicted with cancer comprising selecting a subject that is a suitable candidate for immunotherapy based on an assessment that the proportion of cells in a test tissue sample from the subject that express PD-L1 on the cell surface exceeds a predetermined threshold level, and administering a therapeutically effective amount of an anti-PD-1 antibody to the selected subject. The invention additionally provides rabbit mAbs that bind specifically to a cell surface-expressed PD-L1 antigen in a FFPE tissue sample, and an automated IHC method for assessing cell surface expression in FFPE tissues using the provided anti-PD-L1 Abs.

Isbn (Books And Publications)

Fatigue Behaviour Of Offshore Structures

Author:
Ashok Gupta
ISBN #:
0387170243

Mineral Processing Design And Operations : An Introduction

Author:
Ashok Gupta
ISBN #:
0444516360

Slums In New Industrial Towns: A Study Of Durg-Bhilai In Madhya Pradesh

Author:
Ashok K. Gupta
ISBN #:
8170490677

Economic Development And Price Behaviour In India, Since 1951

Author:
Ashok Kumar Gupta
ISBN #:
8170410657

NOTICE: You may not use BackgroundCheck or the information it provides to make decisions about employment, credit, housing or any other purpose that would require Fair Credit Reporting Act (FCRA) compliance. BackgroundCheck is not a Consumer Reporting Agency (CRA) as defined by the FCRA and does not provide consumer reports.