Bing S Xu, 7819 Gates Ave, Valley Stream, NY 11580

8338151, Dec 25, 2012

Aug 20, 2008

12/194554

Bing Xu - Newton MA, US
Zhimou Yang - Mountain View CA, US
Keming Xu - Hong Kong, CN

The Hong Kong University of Science and Technology - Hong Kong

C12N 1/04
C12N 9/00

435183, 435325, 435243, 424488, 424484

A method of creating intracellular artificial nanostructures in situ, which employees a chemical precursor. The precursor does not self-assemble due to the presence of a cleavable motif linked to it. When the precursor comes inside live cells by an uptaking mechanism on the cell membrane, the cleavable motif is then to be removed by an enzymatic action of a first enzyme. Without the cleavable motif, the precursor now engages in a self-assembling process to form nanostructures within the live cells, which may cause formation of a hydrogel. Furthermore, the self-assembling process can be made reversible by employing a second enzyme which puts the cleavable motif back to the precursor, whereby dissolving the nanostructures into solution.

8506751, Aug 13, 2013

Apr 20, 2010

12/662487

Kit Ying Wong - Hong Kong, CN
Matthew Ming Fai Yuen - Hong Kong, CN
Bing Xu - Newton MA, US

The Hong Kong University of Science and Technology - Kowloon

B32B 7/04
B32B 37/12
B32B 15/04
B32B 15/08
B05D 3/10

156325, 156326, 428413, 428420, 427301

An adhesion bond between a metallic surface layer and a second surface is formed by treating the layers with a material comprising sulphur-containing molecules. The sulphur-containing molecules are applied as a surface treatment of the surfaces, so that the sulphur-containing molecules act as a coupling agent to bond chemically to both substrates form nanometer-sized structures on the surfaces. The nanometer-sized structures are incorporated into a self-assembly interlayer in between the surfaces, with the interlayer forming a bond to both surfaces.

2006012, Jun 15, 2006

Oct 28, 2005

11/261391

Bing Xu - Brooklyn NY, US
Qing-san Xiang - Vancouver, CA

A47B 85/00

108020000

A novel concept of ergodynamic desktops with slowly varying configurations for ergonomic purposes is provided. Very slow motions are incorporated into the design of desktops, usually used by computer users. The introduced motion is at such a slow pace that it is hardly noticeable, similar to the adiabatic motions of hour or minute hands on a clock. Users of the desktops are therefore induced to adjust their body posture accordingly in a gradual and healthy manner, while still continuing to perform their normal activities without interruption. These desktop designs allow a natural and effortless combination of normal life and exercise. When used in a working environment, they will be useful to improve the health and to enhance the efficiency of workers.

2012014, Jun 7, 2012

Jun 24, 2010

13/379801

Yuan Gao - Waltham MA, US
Yi Kuang - Waltham MA, US
Bing Xu - Newton MA, US

A61K 38/07
A61P 35/00
C07K 5/107

514 219, 530330, 514 193, 514 192

Disclosed is a general methodology to create nano fibers of therapeutic molecules that have a dual role, as both the delivery vehicle and the drug itself. It is shown that with proper molecular design, the integration of enzymatic reaction and self-assembly provides a powerful method to create molecular hydrogels of clinically-used therapeutics without compromising their bioactivities. In addition, the results disclosed herein demonstrate enzyme-instructed self-assembly as a facile strategy for generating the supramolecular hydrogels of molecules that inherently have poor solubility in water. For example, by covalently connecting paclitaxel with a motif that is prone to self-assemble, a hydrogel of paclitaxel can be formed without compromising the activity of the paclitaxel.

2013020, Aug 15, 2013

Feb 11, 2013

13/764770

REALD INC. - , US
Bing XU - Bayside NY, US
Yihan Xiong - Lawrenceville NJ, US
Jean-Francois Seurin - West Windsor, NJ, US
Chuni Ghosh - West Windsor NJ, US

REALD INC. - Beverly Hills CA

H01S 5/06

372 22

Disclosed herein are architectures for VCSEL systems. By using high power IR VCSEL element(s), a bulk doubling material can be used to double the IR light and generate visible light (red, green, blue, or UV light) in a cavity, in either continuous wave (CW) or pulsed mode. The reflectivity of the output distributed Bragg reflector (DBR) of these VCSELs can be designed to increase the power in the cavity, rather than the power in the VCSEL laser. By enabling the use of a bulk doubling material in the cavity and directly doubling the VCSEL the device can be inexpensive, simpler, high efficiency, better reliability, and vastly improved manufacturing and alignment tolerances. There are a number of cavity architectures that can be used to double the IR light from the VCSEL(s). The VCSEL(s) can be single elements, or arrays with high intensity elements.

2013026, Oct 10, 2013

Apr 5, 2013

13/857810

Bing XU - Bayside NY, US
Qing Wang - Plainsboro NJ, US
Chuni Ghosh - West Windsor NJ, US

RealD Inc. - Beverly Hills CA

H01S 5/42
H01S 5/06

372 22

Disclosed herein are architectures for an external cavity laser. In some embodiments, the external cavity laser includes vertical cavity surface emitting laser (VCSEL) elements, a Brewster plate, frequency doubling chips, and a microlens array. The Brewster plate is arranged at an angle relative to the light path, and is configured to polarize at least the light received from the VCSELs and propagating on the light path in a first direction, and extract, from the external cavity, frequency-doubled light propagating on the light path in a second direction opposite to the first direction. The doubling chips are operable to receive the light and double the frequency of a portion of the received light. The microlens array is aligned with the VCSEL elements. A mount may be employed to mount the side stack of doubling chips by either side mounting or end mounting.

2020028, Sep 10, 2020

Sep 18, 2018

16/648295

- Waltham MA, US
Bing XU - Newton MA, US

A61K 9/107
C07K 7/06
A61P 35/00
A61K 47/42
A61K 47/69
A61K 31/704

The present invention relates to a branched peptide that includes a first peptide chain and a second peptide chain having its C-terminal amino acid covalently linked to a sidechain of an amino acid residue of the first peptide chain, wherein the first peptide chain includes a plurality of aromatic amino acids and, optionally, an aromatic group linked to an amino terminus of the first peptide chain; and the second peptide chain includes a plurality of hydrophilic amino acids and an enzyme cleavage site. Pharmaceutical compositions containing the branched peptide and one or more therapeutic agents in an aqueous medium are disclosed, where the branched peptides form micelle structures in the aqueous medium. Methods of using the pharmaceutical composition to deliver therapeutic agents, and for treating various disease conditions are also described.

2020002, Jan 23, 2020

Jan 4, 2018

16/476183

- Waltham MA, US
Bing XU - Newton MA, US

A61K 47/54
A61K 47/42
C07K 5/107
A61P 35/00

Disclosed are peptides capable of enzymatically-induced self-assembly to which is conjugated a redox modulator. These peptides are enzymatically responsive hydrogelators, and they can be used to form pericellular hydrogels/nanofibrils upon exposure to target cells that secrete or express a surface bound ectoenzyme having hydrolase activity suitable to induce peptide gelation. These materials, and compositions containing the same, can be used for inhibiting cancer cell migration, inhibiting cancer cell survival, and/or inhibiting cancer cell growth.