Boyd L Yount, 825212 Wolfe Rd, Hickory, NC 28601
Boyd Yount Phones & Addresses
5212 Wolfe Rd, Hickory, NC 28601 828-3288976
Hillsborough, NC
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Financial Professional
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Graduate or professional degree
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Us Patents
Methods For Producing Recombinant Coronavirus
US Patent:
7279327, Oct 9, 2007
Filed:
Apr 19, 2002
Appl. No.:
10/474962
Inventors:
Kristopher M. Curtis - Chapel Hill NC, US
Boyd Yount - Hillsborough NC, US
Ralph S. Baric - Haw River NC, US
Boyd Yount - Hillsborough NC, US
Ralph S. Baric - Haw River NC, US
Assignee:
The University of North Carolina at Chapel Hill - Chapel Hill NC
International Classification:
C12N 15/85
C12N 15/63
C12N 15/63
US Classification:
435325, 4353201, 4242211
Abstract:
A helper cell for producing an infectious, replication defective, (or more generally nidovirus) particle cell comprises (a) a nidovirus permissive cell; (b) a nidovirus replicon RNA comprising the nidovirus packaging signal and a heterologous RNA sequence, wherein the replicon RNA further lacks a sequence encoding at least one nidovirus structural protein; and (c) at least one separate helper RNA encoding the at least one structural protein absent from the replicon RNA, the helper RNA(s) lacking the nidovirus packaging signal. The combined expression of the replicon RNA and the helper RNA in the nidovirus permissive cell produces an assembled nidovirus particle which comprises the heterologous RNA sequence, is able to infect a cell, and is unable to complete viral replication in the absence of the helper RNA due to the absence of the structural protein coding sequence in the packaged replicon. Compositions for use in making such helper cells, along with viral particles produced from such cells, compositions of such viral particles, and methods of making and using such viral particles, are also disclosed.
Compositions Of Coronaviruses With A Recombination-Resistant Genome
US Patent:
7618802, Nov 17, 2009
Filed:
Jan 19, 2006
Appl. No.:
11/334877
Inventors:
Ralph S. Baric - Haw River NC, US
Rhonda Roberts - Durham NC, US
Boyd Yount - Hillsborough NC, US
Kristopher M. Curtis - Frederick MD, US
Rhonda Roberts - Durham NC, US
Boyd Yount - Hillsborough NC, US
Kristopher M. Curtis - Frederick MD, US
Assignee:
The University of North Carolina at Chapel Hill - Chapel Hill NC
International Classification:
C12N 7/01
C12N 15/50
C12N 15/40
C12N 15/86
A61K 39/215
C12N 7/04
C12N 15/50
C12N 15/40
C12N 15/86
A61K 39/215
C12N 7/04
US Classification:
4352351, 4242211, 4242181, 536 2372, 4353201, 435236
Abstract:
The present invention provides a cDNA of a severe acute respiratory syndrome (SARS) coronavirus, recombinant SARS coronavirus vectors, and SARS coronavirus replicon particles. Also provided are methods of making the compositions of this invention and methods of using the compositions as immunogens and/or vaccines and/or to express heterologous nucleic acids.
Directional Assembly Of Large Viral Genomes And Chromosomes
US Patent:
2002017, Nov 28, 2002
Filed:
May 21, 2001
Appl. No.:
09/862847
Inventors:
Ralph Baric - Haw River NC, US
Boyd Yount - Hillsborough NC, US
Boyd Yount - Hillsborough NC, US
International Classification:
C12Q001/70
G01N033/53
C07H021/04
C12N015/00
C12N015/09
C12N015/63
C12N015/70
C12N015/74
C12N015/86
G01N033/53
C07H021/04
C12N015/00
C12N015/09
C12N015/63
C12N015/70
C12N015/74
C12N015/86
US Classification:
435/456000, 435/005000, 435/007100, 435/320100, 536/023700, 536/023720, 536/023740
Abstract:
Full-length, functionally intact genomes or chromosomes are directionally assembled with partial cDNA or DNA subclones of a genome. This approach facilitates the reconstruction of genomes and chromosomes in vitro for reintroduction into a living host, and allows the selected mutagenesis and genetic manipulation of sequences in vitro prior to reassembly into a full length genome molecule for reintroduction into the same or different host. This approach also provides an alternative to recombination-mediated techniques to manipulate the genomes of higher plants and animals as well as bacteria and viruses.
Methods And Compositions For Recombinant Dengue Viruses For Vaccine And Diagnostic Development
US Patent:
2020023, Jul 23, 2020
Filed:
Aug 29, 2019
Appl. No.:
16/555912
Inventors:
- Chapel Hill NC, US
Douglas Widman - Carrboro NC, US
Boyd Yount - Hillsborough NC, US
Emily Gallichotte - Carrboro NC, US
Scott Royal - Carrboro NC, US
Aravinda Desilva - Chapel Hill NC, US
Jesica Swanstrom - Morrisville NC, US
Douglas Widman - Carrboro NC, US
Boyd Yount - Hillsborough NC, US
Emily Gallichotte - Carrboro NC, US
Scott Royal - Carrboro NC, US
Aravinda Desilva - Chapel Hill NC, US
Jesica Swanstrom - Morrisville NC, US
International Classification:
A61K 39/12
C07K 16/10
C12N 7/00
C07K 14/005
G01N 33/569
C07K 16/10
C12N 7/00
C07K 14/005
G01N 33/569
Abstract:
The present invention provides compositions and methods of use comprising a chimeric dengue virus E glycoprotein comprising a dengue virus E glycoprotein backbone, which comprises amino acid substitutions that introduce an epitope that is recognized by an antibody from a dengue virus serotype that is different from the dengue virus serotype of the dengue virus E glycoprotein backbone.
Methods And Compositions For Dengue Virus Serotype 4 Epitopes
US Patent:
2020015, May 21, 2020
Filed:
May 23, 2018
Appl. No.:
16/615350
Inventors:
- Chapel Hill NC, US
Matthew BEGLEY - Durham NC, US
Douglas WIDMAN - Newton Center MA, US
Aravinda DESILVA - Chapel Hill NC, US
Usha NIVARTHI - Morrisville NC, US
Boyd YOUNT - Hillsborough NC, US
Ellen YOUNG - Hillsborough NC, US
Matthew BEGLEY - Durham NC, US
Douglas WIDMAN - Newton Center MA, US
Aravinda DESILVA - Chapel Hill NC, US
Usha NIVARTHI - Morrisville NC, US
Boyd YOUNT - Hillsborough NC, US
Ellen YOUNG - Hillsborough NC, US
International Classification:
A61K 39/12
C07K 14/005
C12N 7/00
A61P 31/14
C07K 14/005
C12N 7/00
A61P 31/14
Abstract:
The present invention provides compositions and methods of use comprising a chimeric dengue virus E glycoprotein comprising a dengue virus E glycoprotein backbone, which comprises amino acid substitutions that introduce a dengue virus E glycoprotein epitope from a dengue virus serotype that is different from the dengue virus serotype of the dengue virus E glycoprotein backbone.
Methods And Compositions For Dengue Virus Vaccines
US Patent:
2019022, Jul 25, 2019
Filed:
Aug 20, 2018
Appl. No.:
16/105346
Inventors:
- Chapel Hill NC, US
Ralph Baric - Haw River NC, US
Aravinda de Silva - Chapel Hill NC, US
Boyd Yount - Hillsborough NC, US
Ralph Baric - Haw River NC, US
Aravinda de Silva - Chapel Hill NC, US
Boyd Yount - Hillsborough NC, US
International Classification:
C07K 14/005
C12N 7/00
C07K 14/18
C07K 16/10
C12N 7/00
C07K 14/18
C07K 16/10
Abstract:
The present invention provides compositions and methods of use comprising a chimeric dengue virus E glycoprotein comprising a dengue virus E glycoprotein backbone, which comprises amino acid substitutions that introduce an epitope that is recognized by an antibody from a dengue virus serotype that is different from the dengue virus serotype of the dengue virus E glycoprotein backbone.
Methods And Compositions For Recombinant Dengue Viruses For Vaccine And Diagnostic Development
US Patent:
2017033, Nov 23, 2017
Filed:
Nov 2, 2015
Appl. No.:
15/523899
Inventors:
- Chapel Hill NC, US
Douglas Widman - Carrboro NC, US
Boyd Yount - Hillsborough NC, US
Emily Gallichotte - Carrboro NC, US
Scott Royal - Carrboro NC, US
Aravinda Desilva - Chapel Hill NC, US
Jesica Swanstrom - Morrisville NC, US
Douglas Widman - Carrboro NC, US
Boyd Yount - Hillsborough NC, US
Emily Gallichotte - Carrboro NC, US
Scott Royal - Carrboro NC, US
Aravinda Desilva - Chapel Hill NC, US
Jesica Swanstrom - Morrisville NC, US
International Classification:
A61K 39/12
C12N 7/00
G01N 33/569
C07K 14/005
A61K 39/00
C12N 7/00
G01N 33/569
C07K 14/005
A61K 39/00
Abstract:
The present invention provides compositions and methods of use comprising a chimeric dengue virus E glycoprotein comprising a dengue virus E glycoprotein backbone, which comprises amino acid substitutions that introduce an epitope that is recognized by an antibody from a dengue virus serotype that is different from the dengue virus serotype of the dengue virus E glycoprotein backbone.
Methods And Compositions For Chimeric Coronavirus Spike Proteins
US Patent:
2017009, Apr 6, 2017
Filed:
Mar 20, 2015
Appl. No.:
15/124992
Inventors:
- Chape Hill NC, US
Sudhakar Agnihothram - Ellicott City MD, US
Boyd Yount - Hillsborough NC, US
Sudhakar Agnihothram - Ellicott City MD, US
Boyd Yount - Hillsborough NC, US
Assignee:
The University of North Carolina at Chapel Hill - Chapel Hill NC
International Classification:
C07K 14/005
A61K 39/12
C07K 16/10
C12N 7/00
A61K 39/12
C07K 16/10
C12N 7/00
Abstract:
The present invention provides compositions and methods comprising a chimeric coronavirus spike protein.
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