Brian Sparling resumes & CV records
Resumes
Brian Sparling
Brian A Sparling, 38Saugus, MA
Brian Sparling Phones & Addresses
Saugus, MA
11 E Wyoming Ave, Melrose, MA 02176 954-6736116
14 Riverside St #G-2, Watertown, MA 02472
Boston, MA
Fort Lauderdale, FL
Work
Position:
Professional/Technical
Education
Degree:
Associate degree or higher
Mentions for Brian A Sparling
Publications & IP owners
Us Patents
Mettl3 Modulators
US Patent:
2023002, Jan 26, 2023
Filed:
Oct 20, 2020
Appl. No.:
17/770708
Inventors:
- Lexington MA, US
Brian Lewis Hodous - Arlington MA, US
Ernest Allen Sickmier - Needham MA, US
James Edward John Mills - Sheffield, GB
Robert A. Copeland - Lexington MA, US
Andrew Stewart Tasker - Simi Valley CA, US
Matthew H. Daniels - Somerville MA, US
Kenneth W. Duncan - Westwood MA, US
Brian Andrew Sparling - Melrose MA, US
Brian Lewis Hodous - Arlington MA, US
Ernest Allen Sickmier - Needham MA, US
James Edward John Mills - Sheffield, GB
Robert A. Copeland - Lexington MA, US
Andrew Stewart Tasker - Simi Valley CA, US
Matthew H. Daniels - Somerville MA, US
Kenneth W. Duncan - Westwood MA, US
Brian Andrew Sparling - Melrose MA, US
Assignee:
Accent Therapeutics, Inc. - Lexington MA
International Classification:
C07D 487/04
C07D 215/04
C07D 221/02
C07D 307/02
A61P 35/02
C07D 215/04
C07D 221/02
C07D 307/02
A61P 35/02
Abstract:
Provided are compounds of Formula (I′) or (II′), or pharmaceutically acceptable salts thereof, and methods for their use and production.
Pyridine Sulfonamides
US Patent:
2019016, Jun 6, 2019
Filed:
Jul 20, 2017
Appl. No.:
16/319783
Inventors:
- Thousand Oaks CA, US
John R. BUTLER - Somerville MA, US
Benjamin Charles MILGRAM - Cambridge MA, US
Alessandro BOEZIO - Somerville MA, US
Brian Andrew SPARLING - Melrose MA, US
Daniel LA - Chestnut Hill MA, US
John R. BUTLER - Somerville MA, US
Benjamin Charles MILGRAM - Cambridge MA, US
Alessandro BOEZIO - Somerville MA, US
Brian Andrew SPARLING - Melrose MA, US
Daniel LA - Chestnut Hill MA, US
Assignee:
AMGEN INC. - Thousand Oaks CA
International Classification:
A61K 31/506
A61P 25/00
A61K 31/4439
A61P 25/00
A61K 31/4439
Abstract:
The present invention provides compounds of Formula (I), as defined in the specification, or pharmaceutically acceptable salts thereof, that are inhibitors of voltage-gated sodium channels, in particular Nav 1.7. The compounds are useful for the treatment of diseases treatable by inhibition of sodium channels such as pain disorders, cough, or itch. Also provided are pharmaceutical compositions containing compounds of the present invention.
Bicyclic Sulfonamide Compounds As Sodium Channel Inhibitors
US Patent:
2016004, Feb 18, 2016
Filed:
Oct 22, 2015
Appl. No.:
14/920833
Inventors:
- Thousand Oaks CA, US
Alessandro BOEZIO - Somerville MA, US
Christiane BOEZIO - Somerville MA, US
John R. BUTLER - Somerville MA, US
Margaret Yuhua CHU-MOYER - Brookline MA, US
Erin F. DIMAURO - Cambridge MA, US
Thomas DINEEN - Somerville MA, US
Russell GRACEFFA - Hampton NH, US
Angel GUZMAN-PEREZ - Belmont MA, US
Hongbing HUANG - Brighton MA, US
Charles KREIMAN - Hopkinton MA, US
Daniel LA - Brookline MA, US
Isaac E. MARX - Arlington MA, US
Benjamin Charles MILGRAM - Cambridge MA, US
Hanh Nho NGUYEN - Jupiter FL, US
Emily Anne PETERSON - Cambridge MA, US
Karina R. VAIDA - Burlington MA, US
Brian SPARLING - Watertown MA, US
Alessandro BOEZIO - Somerville MA, US
Christiane BOEZIO - Somerville MA, US
John R. BUTLER - Somerville MA, US
Margaret Yuhua CHU-MOYER - Brookline MA, US
Erin F. DIMAURO - Cambridge MA, US
Thomas DINEEN - Somerville MA, US
Russell GRACEFFA - Hampton NH, US
Angel GUZMAN-PEREZ - Belmont MA, US
Hongbing HUANG - Brighton MA, US
Charles KREIMAN - Hopkinton MA, US
Daniel LA - Brookline MA, US
Isaac E. MARX - Arlington MA, US
Benjamin Charles MILGRAM - Cambridge MA, US
Hanh Nho NGUYEN - Jupiter FL, US
Emily Anne PETERSON - Cambridge MA, US
Karina R. VAIDA - Burlington MA, US
Brian SPARLING - Watertown MA, US
International Classification:
C07D 471/04
C07D 417/12
C07D 413/14
C07D 413/12
C07D 401/12
C07D 417/12
C07D 413/14
C07D 413/12
C07D 401/12
Abstract:
The present invention provides compounds of Formula I,and pharmaceutically acceptable salts thereof, that are inhibitors of voltage-gated sodium channels, in particular Nav1.7. The compounds are useful for the treatment of diseases associated with the activity of sodium channels such as pain disorders and itch. Also provided are pharmaceutical compositions containing compounds of the present invention.
Bicyclic Sulfonamide Compounds As Sodium Channel Inhibitors
US Patent:
2014037, Dec 18, 2014
Filed:
Jun 11, 2014
Appl. No.:
14/302337
Inventors:
- Thousand Oaks CA, US
Alessandro BOEZIO - Somerville MA, US
Christiane BOEZIO - Somerville MA, US
John R. BUTLER - Somerville MA, US
Margaret Yuhua CHU-MOYER - Brookline MA, US
Erin F. DIMAURO - Cambridge MA, US
Thomas DINEEN - Somerville MA, US
Russell GRACEFFA - Hampton NH, US
Angel GUZMAN-PEREZ - Belmont MA, US
Hongbing HUANG - Lexington MA, US
Charles KREIMAN - Belmont MA, US
Daniel LA - Brookline MA, US
Isaac E. MARX - Cambridge MA, US
Benjamin Charles MILGRIM - Cambridge MA, US
Hanh Nho NGUYEN - Arlington MA, US
Emily PETERSON - Cambridge MA, US
Karina ROMERO - Arlington MA, US
Brian SPARLING - Watertown MA, US
Alessandro BOEZIO - Somerville MA, US
Christiane BOEZIO - Somerville MA, US
John R. BUTLER - Somerville MA, US
Margaret Yuhua CHU-MOYER - Brookline MA, US
Erin F. DIMAURO - Cambridge MA, US
Thomas DINEEN - Somerville MA, US
Russell GRACEFFA - Hampton NH, US
Angel GUZMAN-PEREZ - Belmont MA, US
Hongbing HUANG - Lexington MA, US
Charles KREIMAN - Belmont MA, US
Daniel LA - Brookline MA, US
Isaac E. MARX - Cambridge MA, US
Benjamin Charles MILGRIM - Cambridge MA, US
Hanh Nho NGUYEN - Arlington MA, US
Emily PETERSON - Cambridge MA, US
Karina ROMERO - Arlington MA, US
Brian SPARLING - Watertown MA, US
International Classification:
C07D 471/04
C07D 401/12
C07D 215/227
C07D 417/12
C07C 53/18
C07D 413/12
C07D 413/14
C07D 401/12
C07D 215/227
C07D 417/12
C07C 53/18
C07D 413/12
C07D 413/14
US Classification:
51421021, 546157, 514312, 544297, 514275, 544327, 514256, 544238, 51425204, 544405, 51425505, 546122, 514300, 544354, 514249
Abstract:
The present invention provides compounds of Formula I,and pharmaceutically acceptable salts thereof, that are inhibitors of voltage-gated sodium channels, in particular Nav1.7. The compounds are useful for the treatment of diseases associated with the activity of sodium channels such as pain disorders and itch. Also provided are pharmaceutical compositions containing compounds of the present invention.
Hyperforin Analogs, Methods Of Synthesis, And Uses Thereof
US Patent:
2014013, May 15, 2014
Filed:
Jun 1, 2012
Appl. No.:
14/123255
Inventors:
Matthew D. Shair - Lexington MA, US
Brian A. Sparling - Watertown MA, US
David Moebius - Cambridge MA, US
Brian A. Sparling - Watertown MA, US
David Moebius - Cambridge MA, US
Assignee:
President and Fellows of Harvard College - Cambridge MA
International Classification:
C07C 49/753
C07C 45/29
C07F 7/08
C07D 493/08
C07C 45/29
C07F 7/08
C07D 493/08
US Classification:
514 63, 568374, 514691, 549459, 556445, 568373, 556427, 556431
Abstract:
The present invention provides a novel 11-step enantioselective approach to the natural product hyperforin, which enables access to a wide variety of hyperforin analogs. The present invention also provides pharmaceutical compositions comprising inventive hyperforin analogs. Hyperforin analogs synthesized using the present synthetic method are envisioned useful in the treatment of various conditions, including, but not limited to, depression and conditions characterized by depression, inflammatory skin conditions, diabetes, asthma, chronic obstructive pulmonary disease (COPD), kidney disorders, and ischemic brain damage.
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