Brian N Zeiler, 57418 Beech St, Township Of Washington, NJ 07676

2005026, Nov 24, 2005

Apr 22, 2005

11/113440

Abraham Grossman - Pleasantonville NY, US
Valentine Kryukov - Pushino, RU
Brian Zeiler - Glen Rock NJ, US

Q-RNA - New York NY

C07H021/02

536023100

Amplibody compositions and methods used to interact with agglomeration proteins and initiate and mediate an aggregation cascade are disclosed herein. Compositions herein comprise one or more DNA or RNA molecules having affinity for at least one agglomeration protein. The nucleic acid component is a naturally occurring or non-naturally occurring molecule with twenty or more ribonucleotide bases. For RNA, at least one nucleotide sequence portion of this RNA molecule has affinity to at least one consensus sequence present in the agglomeration RNA-binding protein. The isolated RNA molecules of the present invention bind agglomeration proteins to initiate and mediate the progression of a nucleo-protein aggregation cascade. The nucleo-protein aggregation cascade can be self-catalyzing, with formation of intermediate aggregates comprising an RNA molecule and one or more agglomeration proteins.

2005026, Dec 1, 2005

Apr 22, 2005

11/112929

Abraham Grossman - Pleasantville NY, US
Valentine Kryukov - Puschino, RU
Brian Zeiler - Washington Township NJ, US

Q-RNA - New York NY

C12Q001/70
C12Q001/68

435005000, 435006000

Amplibody compositions and methods used to interact with agglomeration proteins are disclosed herein. Compositions herein comprise one or more DNA or RNA molecules having affinity for at least one agglomeration protein. The nucleic acid component is a naturally or non-naturally occuring molecule with twenty or more ribonucleotide bases. For RNA, at least one nucleotide sequence portion of this RNA molecule has affinity to at least one consensus sequence present in the agglomeration RNA-binding protein. The portion of nucleotide sequence of RNA having affinity for agglomeration proteins is a sequence that is derived from either and RNA virus, and RNA agglomeration proteins is a sequence that is derived from either and RNA virus, an RNA phage, a messenger RNA (“mRNA”), a ribosomal RNA (“rRNA), a transfer RNA (“tRNA”), a sequence that is received as a template by one or more RNA dependent RNA polymerases, or a combination thereof. Methods disclosed herein are directed towards detecting the presence of one or more agglomeration proteins in a sample matrix using the amplibody compositions described herein.

2005026, Dec 1, 2005

Apr 22, 2005

11/112954

Abraham Grossman - Pleasantville NY, US
Valentine Kryukov - Puschino, RU
Brian Zeiler - Washington Township NJ, US

Q-RNA - New York NY

C12Q001/70
C12Q001/68

435005000, 435006000

Amplibody compositions and methods used to interact with agglomeration proteins are disclosed herein. Compositions herein comprise one or more DNA or RNA molecules having affinity for at least one agglomeration protein. The nucleic acid component is a naturally or non-naturally occuring molecule with twenty or more ribonucleotide bases. For RNA, at least one nucleotide sequence portion of this RNA molecule has affinity to at least one consensus sequence present in the agglomeration RNA-binding protein. The portion of nucleotide sequence of RNA having affinity for agglomeration proteins is a sequence that is derived from either and RNA virus, and RNA agglomeration proteins is a sequence that is derived from either and RNA virus, an RNA phage, a messenger RNA (“mRNA”), a ribosomal RNA (“rRNA”), a transfer RNA (“tRNA”), a sequence that is received as a template by one or more RNA dependent RNA polymerases, or a combination thereof. Methods disclosed herein are directed towards detecting the presence of one or more agglomeration proteins in a sample matrix using the amplibody compositions described herein.

2006002, Feb 2, 2006

Apr 22, 2005

11/112953

Abraham Grossman - Pleasantville NY, US
Valentine Kryukov - Puschino, RU
Brian Zeiler - Washington Township NJ, US

Q-RNA - New York NY

C12Q 1/70
C12Q 1/68

435006000, 435005000

Amplibody compositions and methods used to interact with agglomeration proteins are disclosed herein. Compositions herein comprise one or more DNA or RNA molecules having affinity for at least one agglomeration protein. The nucleic acid component is a naturally or non-naturally occuring molecule with twenty or more ribonucleotide bases. For RNA, at least one nucleotide sequence portion of this RNA molecule has affinity to at least one consensus sequence present in the agglomeration RNA-binding protein. The portion of nucleotide sequence of RNA having affinity for agglomeration proteins is a sequence that is derived from either and RNA virus, and RNA agglomeration proteins is a sequence that is derived from either and RNA virus, an RNA phage, a messenger RNA (“mRNA”), a ribosomal RNA (“rRNA), a transfer RNA (“tRNA”), a sequence that is received as a template by one or more RNA dependent RNA polymerases, or a combination thereof. Methods disclosed herein are directed towards detecting the presence of one or more agglomeration proteins in a sample matrix using the amplibody compositions described herein.

2006014, Jun 29, 2006

Dec 18, 2003

10/539850

Brian Zeiler - Washington Township NJ, US

Q-RNA, Inc. - New York NY

C12Q 1/68
C12P 19/34

435006000, 435091200

Embodiments of the present invention are directed to methods and kits for the generation of double stranded RNA by RNA dependent RNA polymerases. The methods and kits feature exponential generation of such RNAs through simple steps/ The RNA is suitable for interference with expression in cells.