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Fook T Cheong, 56Astoria, NY

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Tham Fook Cheg

Tham Fook Cheong or best known as Master Tham is a notable person in Malaysia. He is well known for his contribution in welfare activities, community services as well as in the ...

Us Patents

Holographic Microscopy Of Holographically Trapped Three-Dimensional Nanorod Structures

US Patent:
2010025, Oct 7, 2010
Filed:
Apr 14, 2010
Appl. No.:
12/759839
Inventors:
Fook Chiong CHEONG - New York NY, US
David G. Grier - New York NY, US
Sang-Hyuk Lee - Albany CA, US
International Classification:
H04N 7/00
G03H 1/08
G02B 21/32
H04N 5/89
US Classification:
348 31, 359 9, 348 40, 348E13001
Abstract:
A method and system for performing three-dimensional holographic microscopy of an optically trapped one dimensional structure. The method and system use an inverted optical microscope, a laser source which generates a trapping laser beam wherein the laser beam is focused by an objective lens into a plurality of optical traps. The method and system also use a collimated laser at an imaging wavelength to illuminate the structure created by the optical traps. Imaging light scattered by the optically tapped structure forms normalized intensity holograms that are imaged by a video camera and analyzed by optical formalisms to determine light field to reconstruct 3-D images for analysis and evaluation.

Tracking And Characterizing Particles With Holographic Video Microscopy

US Patent:
2011004, Feb 24, 2011
Filed:
Oct 30, 2008
Appl. No.:
12/740628
Inventors:
David G. Grier - New York NY, US
Sang-Hyuk Lee - Rego Park NY, US
Fook C. Cheong - New York NY, US
International Classification:
H04N 5/89
G01B 9/02
US Classification:
348 40, 356450, 348E07085
Abstract:
In-line holography to create images of a specimen, such as one or more particles dispersed in a transparent medium. Analyzing these images with results from light scattering theory yields the particles' sizes with nanometer resolution, their refractive indexes to within one part in a thousand, and their three dimensional positions with nanometer resolution. This procedure can rapidly and directly characterize mechanical, optical and chemical properties of the specimen and its medium.

Automated Real-Time Particle Characterization And Three-Dimensional Velocimetry With Holographic Video Microscopy

US Patent:
2012013, May 31, 2012
Filed:
Jan 14, 2010
Appl. No.:
13/254403
Inventors:
David G. Grier - New York NY, US
Fook Chiong Cheong - New York NY, US
Ke Xiao - Elmhurst NY, US
International Classification:
G06K 9/46
H04N 7/18
G01N 21/00
US Classification:
436164, 382103, 348 79, 348E07085
Abstract:
An in-line holographic microscope can be used to analyze on a frame-by-frame basis a video stream to track individual colloidal particles' three-dimensional motions. The system and method can provide real time nanometer resolution, and simultaneously measure particle sizes and refractive indexes. Through a combination of applying a combination of Lorenz-Mie analysis with selected hardware and software methods, this analysis can be carried out in near real time. An efficient particle identification methodology automates initial position estimation with sufficient accuracy to enable unattended holographic tracking and characterization.

Method And Sysem For Measuring Porosity Of Particles

US Patent:
2013027, Oct 24, 2013
Filed:
Nov 4, 2011
Appl. No.:
13/883260
Inventors:
Fook Chiong Cheong - New York NY, US
Ke Xiao - Elmhurst NY, US
David Pine - New York NY, US
David G. Grier - New York NY, US
Assignee:
New York University - New York NY
International Classification:
G02B 21/36
US Classification:
348 79
Abstract:
A method for analyzing porosity of a particle and a medium disposed in the porosity of the particle. A video-holographic microscope is provided to analyze interference patterns produced by providing a laser source to output a collimated beam, scattering the collimated beam off a particle and interacting with an unscattered beam to generate the interference pattern for analyzation to determine the refractive index of the particle and a medium disposed in the porosity of the particle to measure porosity and the medium.

Holographic Characterization Of Protein Aggregates

US Patent:
2022032, Oct 13, 2022
Filed:
May 27, 2022
Appl. No.:
17/826848
Inventors:
- New York NY, US
Michael D. WARD - New York NY, US
Xiao ZHONG - Jersey City NJ, US
Chen WANG - New York NY, US
Laura A. PHILIPS - New York NY, US
David B. RUFFNER - New York NY, US
Fook Chiong CHEONG - New York NY, US
Assignee:
NEW YORK UNIVERSITY - New York NY
International Classification:
G01N 15/02
G01N 15/14
Abstract:
Systems and methods for holographic characterization of protein aggregates. Size and refractive index of individual aggregates in a solution can be determined. Information regarding morphology and porosity can be extracted from holographic data.

Automated Holographic Video Microscopy Assay

US Patent:
2021027, Sep 9, 2021
Filed:
Mar 9, 2021
Appl. No.:
17/196895
Inventors:
- New York NY, US
Fook Chiong CHEONG - Brooklyn NY, US
Kaitlynn SNYDER - New York NY, US
Rushna QUADDUS - New York NY, US
Lauren E. ALTMAN - New York NY, US
Kent KIRSHENBAUM - New York NY, US
International Classification:
G06T 7/00
G01N 15/14
G06T 7/62
G03H 1/00
G03H 1/04
G02B 21/36
Abstract:
An in-line holographic microscope can be used to analyze a video stream to track individual colloidal particles' three-dimensional motions. The system and method can provide real time nanometer resolution, and simultaneously measure particle sizes and refractive indexes. An assay using the holographic microscope for holographic particle characterization directly detect viruses, antibodies and related targets binding to the surfaces of specifically functionalized micrometer-scale colloidal probe beads. The system detects binding of targets by directly measuring associated changes in the bead's diameter without the need for downstream labeling and analysis.

Holographic Characterization Of Irregular Particles

US Patent:
2021012, Apr 29, 2021
Filed:
Oct 23, 2020
Appl. No.:
17/079167
Inventors:
- New York NY, US
Fook Chiong CHEONG - New York NY, US
Annemarie WINTERS - New York NY, US
Jesse J. ELLIOTT - New York NY, US
Laura A. PHILIPS - New York NY, US
International Classification:
G01N 15/02
G03H 1/00
G01N 15/08
Abstract:
Holographic Video Microscopy analysis of non-spherical particles is disclosed herein. Properties of the particles are determined by application of light scattering theory to holography data. Effective sphere theory is applied to provide information regarding the reflective index of a sphere that includes a target particle. Known particles may be co-dispersed with unknown particles in a medium and the holographic video microscopy is used to determine properties, such as porosity, of the unknown particles.

Holographic Characterization Using Hu Moments

US Patent:
2019023, Aug 1, 2019
Filed:
Aug 24, 2017
Appl. No.:
16/328196
Inventors:
- New York NY, US
Laura PHILIPS - New York NY, US
Fook Chiong CHEONG - New York NY, US
International Classification:
G01N 15/02
G01N 15/14
G03H 1/00
G03H 1/08
Abstract:
Holographic microscopy analysis system and methods for determining morphology of a particle in a sample. A bright-field reconstruction image is generated from a recorded hologram from a holographic microscopy system. Morphology of particles imaged by the system may be determined. Hu moments are calculated, either from the hologram or from the bright-field reconstruction, or both, to provide an indication of morphology.

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