Chien Tuan Chang, 64Bear, DE

7521056, Apr 21, 2009

Mar 28, 2006

11/391584

Chien Hsing Chang - Downingtown PA, US
David M. Goldenberg - Mendham NJ, US
William J. McBride - Boonton NJ, US
Edmund A. Rossi - Nutley NJ, US

IBC Pharmaceuticals, Inc. - Morris Plains NJ

A61K 38/01
A61K 38/19
A61K 38/21
A61K 39/395
C07K 14/52
C07K 14/535
C07K 14/405
C07K 14/56

4241921, 4241341, 4241351, 4241441, 4241451, 4241551, 4241851, 4241931, 42419511, 530351, 5303871, 5303873, 53038822, 53038823, 53038824, 5303913, 5303917

The present invention concerns methods and compositions for stably tethered structures of defined compositions with multiple functionalities and/or binding specificities. Particular embodiments concern stably tethered structures comprising a homodimer of a first monomer, comprising a dimerization and docking domain attached to a first precursor, and a second monomer comprising an anchoring domain attached to a second precursor. The first and second precursors may be virtually any molecule or structure, such as antibodies, antibody fragments, antibody analogs or mimetics, aptamers, binding peptides, fragments of binding proteins, known ligands for proteins or other molecules, enzymes, detectable labels or tags, therapeutic agents, toxins, pharmaceuticals, cytokines, interleukins, interferons, radioisotopes, proteins, peptides, peptide mimetics, polynucleotides, RNAi, oligosaccharides, natural or synthetic polymeric substances, nanoparticles, quantum dots, organic or inorganic compounds, etc. The disclosed methods and compositions provide a simple, easy to purify way to obtain any binary compound attached to any monomeric compound, or any trinary compound.

7534866, May 19, 2009

Jun 29, 2006

11/478021

Chien Hsing Chang - Downingtown PA, US
David M. Goldenberg - Mendham NJ, US
William J. McBride - Boonton NJ, US
Edmund A. Rossi - Nutley NJ, US

IBC Pharmaceuticals, Inc. - Morris Plains NJ

A61K 51/00
C07K 16/46
C12Q 1/68
G01N 33/53

530350, 530363, 5303871, 5303873, 530402, 530403, 424 141, 424 149, 424 153, 4241341, 4241921, 4241931, 4241941, 42419511

The present invention concerns methods and compositions for making and using bioactive assemblies of defined compositions, which may have multiple functionalities and/or binding specificities. In particular embodiments, the bioactive assembly is formed using dock-and-lock (DNL) methodology, which takes advantage of the specific binding interaction between dimerization and docking domains (DDD) and anchoring domains (AD) to form the assembly. In various embodiments, one or more effectors may be attached to a DDD or AD sequence. Complementary AD or DDD sequences may be attached to an adaptor module that forms the core of the bioactive assembly, allowing formation of the assembly through the specific DDD/AD binding interactions. Such assemblies may be attached to a wide variety of effector moieties for treatment, detection and/or diagnosis of a disease, pathogen infection or other medical or veterinary condition.

7550143, Jun 23, 2009

Mar 24, 2006

11/389358

Chien Hsing Chang - Downingtown PA, US
David M. Goldenberg - Mendham NJ, US
William J. McBride - Boonton NJ, US
Edmund A. Rossi - Nutley NJ, US

IBC Pharmaceuticals, Inc. - Morris Plains NJ

C07K 16/46
C07K 16/28
C07K 16/30
A61K 38/01
A61K 38/19
A61K 39/395

4241341, 4241381, 4241431, 4241441, 4241521, 4241781, 4241851, 4241921, 4241931, 4241981, 530324, 530350, 5303873, 53038822, 5303887, 53038873, 5303888, 53038885

The present invention concerns methods and compositions for stably tethered structures of defined compositions, which may have multiple functionalities and/or binding specificities. Particular embodiments concern homodimers comprising monomers that contain a dimerization and docking domain attached to a precursor. The precursors may be virtually any molecule or structure, such as antibodies, antibody fragments, antibody analogs or mimetics, aptamers, binding peptides, fragments of binding proteins, known ligands for proteins or other molecules, enzymes, detectable labels or tags, therapeutic agents, toxins, pharmaceuticals, cytokines, interleukins, interferons, radioisotopes, proteins, peptides, peptide mimetics, polynucleotides, RNAi, oligosaccharides, natural or synthetic polymeric substances, nanoparticles, quantum dots, organic or inorganic compounds, etc. Other embodiments concern tetramers comprising a first and second homodimer, which may be identical or different. The disclosed methods and compositions provide a facile and general way to obtain homodimers, homotetramers and heterotetramers of virtually any functionality and/or binding specificity.