Christopher M Degiorgio, 6726621 Oak Terrace Pl, Santa Clarita, CA 91381

8380315, Feb 19, 2013

Oct 5, 2010

12/898686

Christopher DeGiorgio - Valencia CA, US
Ian A. Cook - Los Angeles CA, US
Alejandro Covalin - Culver City CA, US
Patrick R. Miller - Santa Monica CA, US
Lara Schrader - Pacific Palisades CA, US

The Regents of the University of California - Oakland CA

A61N 1/00

607 45

The present disclosure relates to methods, devices and systems used for the treatment of mood, anxiety, post traumatic stress disorder, and cognitive and behavioral disorders (collectively, neuropsychiatric disorders) via stimulation of the superficial elements of the trigeminal nerve (“TNS”). More specifically, cutaneous methods of stimulation of the superficial branches of the trigeminal nerve located extracranially in the face, namely the supraorbital, supratrochlear, infraorbital, auriculotemporal, zygomaticotemporal, zygomaticoorbital, zygomaticofacial, infraorbital, nasal and mentalis nerves (also referred to collectively as the superficial trigeminal nerve) are disclosed herein.

2011010, May 5, 2011

Oct 5, 2010

12/898696

Christopher DeGiorgio - Valencia CA, US
Ian A. Cook - Los Angeles CA, US
Leon Ekchian - Glendale CA, US

The Regents of the University of California - Oakland CA
Neurosigma, Inc. - Los Angeles CA

A61N 1/36

607 72

The present disclosure relates to methods, devices and systems used for the treatment of neurological disorders via stimulation of the superficial elements of the trigeminal nerve (“TNS”). More specifically, minimally invasive methods of stimulation of the superficial branches of the trigeminal nerve located extracranially in the face, namely the supraorbital, supratrochlear, infratrochlear, auriculotemporal, zygomaticotemporal, zygomaticoorbital, zygomaticofacial, nasal, infraorbital, and mentalis nerves (also referred to collectively as the superficial trigeminal nerve) are disclosed herein. Systems and devices configured for therapeutic stimulation of the branches of the trigeminal nerves, such as the superficial trigeminal nerve, and their methods of application are also described.

2011011, May 12, 2011

Oct 5, 2010

12/898685

Christopher DEGIORGIO - Valencia CA, US
Ian A. COOK - Los Angeles CA, US
Leon EKCHIAN - Glendale CA, US

The Regents of the University of California - Oakland CA
Neurosigma, Inc. - Los Angeles CA

A61N 1/36
A61N 1/05

607 45, 607116

The present disclosure relates to methods, devices, and systems used for the treatment of mood, anxiety, cognitive, and behavioral disorders (collectively, neuropsychiatric disorders) via stimulation of the superficial elements of the trigeminal nerve (“TNS”). More specifically, minimally invasive systems, devices and methods of stimulation of the superficial branches of the trigeminal nerve located extracranially in the face, namely the supraorbital, supratrochlear, infraorbital, auriculotemporal, zygomaticotemporal, zygomaticoorbital, zygomaticofacial, nasal and mentalis nerves (also referred to collectively as the superficial trigeminal nerve) are disclosed herein.

2011021, Sep 8, 2011

Oct 5, 2010

12/898675

Christopher DeGIORGIO - Valencia CA, US
Ian A. COOK - Los Angeles CA, US
Alejandro COVALIN - Culver City CA, US

The Regents of the University of California - Oakland CA

A61N 1/36
A61N 1/04

607 45, 607115

The present disclosure relates to methods, devices, and systems used for the treatment of and/or promoting recovery from various neurological disorders and conditions, including epilepsy and other seizure disorders and movement and other related disorders; for promoting recovery from acute or chronic brain injury (e.g. stroke, hypoxia/ischemia, head trauma, subarachnoid hemorrhage, and other forms of brain injury, for awakening and/or promoting the recovery of patients in various levels of coma, altered mental status or vegetative state); or for promoting recovery from chronic daily headache and migraine and related disorders via external (cutaneous) stimulation of the sensory branches of the trigeminal nerve in the face and forehead. More specifically, devices and electrode assemblies configured for stimulation of the supraorbital, supratrochlear, infraorbital, auriculotemporal, zygomaticotemporal, zygomaticoorbital, zygomaticofacial, nasal and infratrochlear nerves are disclosed.

2014008, Mar 20, 2014

Nov 30, 2011

13/990348

Ian A. Cook - Los Angeles CA, US
Christopher M. DeGiorgio - Valencia CA, US
Leon Ekchian - Glendale CA, US
Patrick Miller - Santa Monica CA, US
Colin Kealey - Los Angeles CA, US

NEUROSIGMA, INC. - Los Angeles CA
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA - Oakland CA

A61N 1/36

607 59

Disclosed herein is a system for trigeminal nerve stimulation. In one embodiment, the system includes a storage medium, a pulse generator in communication with the storage medium, a power source coupled to the pulse generator, and at least one electrode communicatively coupled to the pulse generator. The pulse generator includes a microcontroller which executes instructions from the storage medium and the microcontroller is configured to perform at least one of the following operations: produce electrical pulses having defined characteristics, record a log of use and anomalous events, restrict use to a specified individual, interface with electrodes, provide a signal to the specified individual indicating operational conditions and trouble conditions, and provide a signal to the specified individual indicating an end of a treatment period.

2022021, Jul 7, 2022

Dec 2, 2021

17/541154

- Oakland CA, US
Eberhardt K. SAUERLAND - Reno NV, US
Christopher M. DeGiorgio - Valencia CA, US

A61B 5/00
A61H 23/02

A method for reducing epileptic seizures in a subject includes the steps of providing a vibration motor coupled to a controller configured to control vibratory motion of the vibration motor, positioning at least one vibration motor on a limb of the subject, and generating a vibratory stimulation signal configured to stimulate proprioceptive nerves in the limb to trigger kinesthetic cues that stimulate nerves in cerebellar and pontine areas of the brain to suppress seizure activity.

2018022, Aug 16, 2018

Apr 10, 2018

15/949987

- Oakland CA, US
Christopher M. DeGiorgio - Valencia CA, US

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA - Oakland CA

A61N 1/05
A61N 1/36

The present disclosure relates to methods, devices and systems used for the treatment of medical disorders via stimulation of the superficial elements of the trigeminal nerve. More specifically, minimally invasive systems, devices and methods of stimulation of the superficial branches of the trigeminal nerve located extracranially in the face, namely the supraorbital, supratrochlear, infraorbital, auriculotemporal, zygomaticotemporal, zygomaticoorbital, zygomaticofacial, nasal and mentalis nerves (also referred to collectively as the superficial trigeminal nerve) are disclosed herein.

2018000, Jan 4, 2018

Jul 14, 2017

15/650707

- Oakland CA, US
Christopher M. DeGiorgio - Valencia CA, US

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA - Oakland CA

A61N 1/04
A61N 1/36
A61N 1/05

The present disclosure relates to methods, devices and systems used for the treatment of medical disorders via stimulation of the superficial elements of the trigeminal nerve. More specifically, cutaneous methods of stimulation of the superficial branches of the trigeminal nerve located extracranially in the face, namely the supraorbital, supratrochlear, infraorbital, auriculotemporal, zygomaticotemporal, zygomaticoorbital, zygomaticofacial, infraorbital, nasal and mentalis nerves (also referred to collectively as the superficial trigeminal nerve) are disclosed herein.