Colleen M Stack, 44602 Circle Dr, Trent Woods, NC 28562

2014005, Feb 20, 2014

Oct 28, 2013

14/064544

William E Sanders - Chapel Hill NC, US
Richard S Stack - Chapel Hill NC, US
Colleen Stack - Chapel Hill NC, US

Synecor LLC - Chapel Hill NC

A61N 1/362
A61N 1/05

607 14, 607122

A neuromodulation system for treating acute heart failure syndromes includes a first catheter having a parasympathetic therapy element adapted for positioning within a first blood vessel such as a superior vena cava, and a second catheter sympathetic therapy element adapted for positioning with a second, different, blood vessel such as the pulmonary artery. The catheters comprise a system in which one of catheters is slidably disposed over the other of the catheters. The system may further be slidably disposed over a third elongate element such as a Swan-Ganz catheter positionable within a pulmonary artery, such that the Swan-Ganz may be used for monitoring parameters such as blood pressure and cardiac output during neuromodulation therapy. The parasympathetic therapy element is energized to deliver neuromodulation therapy to a parasympathetic nerve fiber such as a vagus nerve, while the sympathetic therapy element is energized to deliver neuromodulation therapy to a sympathetic nerve fiber such as a sympathetic cardiac nerve fiber. For treatment of acute heart failure syndromes, the neuromodulation therapy may be used to lower heart rate and increase cardiac inotropy.

2012020, Aug 16, 2012

Sep 1, 2010

13/393248

Kenneth W. Lyles - Durham NC, US
Cathleen S. Colon-Emeric - Durham NC, US
Christopher M. O'Connor - Durham NC, US
Richard S. Stack - Chapel Hill NC, US
Colleen Stack - Chapel Hill NC, US

A61K 31/675
A61P 9/00
C07F 9/40

514 94, 548112

The present invention provides for methods and compositions for treating and/or preventing cardiac dysfunction by administering to subject a therapeutically effective amount of a bisphosphonate, functional analogue or a pharmaceutically effective salt thereof.

2019024, Aug 15, 2019

Apr 27, 2019

16/396665

- Dublin, IE
Richard A. Glenn - Santa Rosa CA, US
Michael S. Williams - Santa Rosa CA, US
William L. Athas - Chapel Hill NC, US
Colleen Stack - Chapel Hill NC, US

Minimally Invasive Surgical Access Limited - Dublin

A61F 2/01
A61B 17/12

A system for use in performing aortic valve procedures using an instrument disposed through an aortic arch includes a lubricious track positionable within the aortic arch such that a lubricious inferior surface of the track is exposed to the interior of the aortic arch. An instrument to be used in performing the valve procedure is configured to be percutaneously introduced into a femoral artery, advanced through the descending aorta and into the aortic arch, and moved into sliding contact with the lubricous inferior surface of the track. The instrument is advanceable along the lubricious surface until its distal portion is at a target site for the aortic valve procedure.

2018012, May 10, 2018

Jan 8, 2018

15/864327

- Durham NC, US
CATHLEEN S. COLON-EMERIC - DURHAM NC, US
CHRISTOPHER M. O'CONNOR - DURHAM NC, US
RICHARD S. STACK - CHAPEL HILL NC, US
COLLEEN STACK - CHAPEL HILL NC, US

A61K 31/663
A61K 31/66

The present invention provides for methods and compositions for treating and/or preventing cardiac dysfunction by administering to subject a therapeutically effective amount of a bisphosphonate, functional analogue or a pharmaceutically effective salt thereof.

2017006, Mar 9, 2017

Sep 8, 2015

14/847783

- Chapel Hill NC, US
William E. Sanders - Chapel Hill NC, US
Richard S. Stack - Chapel Hill NC, US
Colleen Stack - Chapel Hill NC, US

A61N 1/36
A61N 1/362
A61N 1/05

A neuromodulation system for treating acute heart failure syndromes includes a first catheter having a parasympathetic therapy element adapted for positioning within a first blood vessel such as a superior vena cava, and a second catheter sympathetic therapy element adapted for positioning with a second, different, blood vessel such as the pulmonary artery.The catheters comprise a system in which one of catheters is slidably disposed over the other of the catheters. The system may further be slidably disposed over a third elongate element such as a Swan-Ganz catheter positionable within a pulmonary artery, such that the Swan-Ganz may be used for monitoring parameters such as blood pressure and cardiac output during neuromodulation therapy. The parasympathetic therapy element is energized to deliver neuromodulation therapy to a parasympathetic nerve fiber such as a vagus nerve, while the sympathetic therapy element is energized to deliver neuromodulation therapy to a sympathetic nerve fiber such as a sympathetic cardiac nerve fiber. For treatment of acute heart failure syndromes, the neuromodulation therapy may be used to lower heart rate and increase cardiac inotropy.

2016025, Sep 1, 2016

Feb 11, 2015

14/619069

- Durham NC, US
Michael S. Williams - Santa Rosa CA, US
Daniel W. Fifer - Santa Rosa CA, US
Richard A. Glenn - Santa Rosa CA, US
Geoffrey A Orth - Sebastopol CA, US
Lynn Elliott - Maple Grove MN, US
Colleen Stack - Durham NC, US

A61N 1/36
A61N 1/05

An intravascular electrode system includes an intravascular lead including a spiral section, and a plurality of electrodes on the spiral section. The electrodes are positioned to form a plurality of circumferentially-spaced longitudinal electrode arrays, each longitudinal array energizable independently from the other longitudinal arrays.

2014017, Jun 19, 2014

Aug 24, 2013

13/975331

- Chapel Hill NC, US
Richard A. Glenn - Chapel Hill NC, US
Michael S. Williams - Santa Rosa CA, US
William L. Athas - Chapel Hill NC, US
Colleen Stack - Chapel Hill NC, US

A61F 2/01

606200

A device for facilitating use of instruments disposed through an aortic arch includes an embolic deflector having a first surface positionable in contact with a wall of an aortic arch such that a porous barrier portion of the embolic deflector covers ostia of at least the brachiocephalic and left common carotid arteries. A second surface is disposed on an opposite face from the first surface. A lubricious guide track is disposed on the second surface and extends longitudinally on the embolic deflector. The deflector and/or guide track is supported by a shaft that is extendable through a femoral artery and descending aorta to position the guide within the aortic arch. During use, the device is percutaneously introduced via the femoral artery and advanced into the aorta. The porous barrier portion of the deflector is positioned over the target ostia, and the guide track thus faces into the aortic arch. An instrument passed through the aortic arch, such as an aortic valve delivery system introduced via a femoral artery, is advanced along the lubricious guide track towards a target site (e.g. the aortic valve), minimizing contact between the instrument and the wall of the aorta.

2014014, May 29, 2014

Apr 23, 2013

13/869024

- Larkspur CA, US
Michael S. Williams - Santa Rosa CA, US
Daniel W. Fifer - Santa Rosa CA, US
Richard A. Glenn - Santa Rosa CA, US
Geoffrey A. Orth - Sebastopol CA, US
Lynn Elliott - Maple Grove MN, US
Colleen Stack - Durham NC, US

Synecor LLC - Larkspur CA

A61N 1/05

607116

An intravascular electrode system includes an expandable anchor and a flexible substrate which carries at least one electrode. The anchor is positioned in a blood vessel and expanded to an expanded position to bias the electrode in contact with the vessel wall. The flexible substrate may be longitudinally withdrawn from its position between the anchor and the vessel wall without removing the anchor from the blood vessel. A second flexible substrate may be longitudinally inserted into position between the anchor and vessel wall as replacement for the first substrate.