Connie M Oshiro, 712446 Benjamin Dr, Mountain View, CA 94043
Connie Oshiro Phones & Addresses
2446 Benjamin Dr, Mountain View, CA 94043
Palo Alto, CA
Clarksville, TN
Honolulu, HI
Work
Position:
Professional/Technical
Education
Degree:
High school graduate or higher
Mentions for Connie M Oshiro
Publications & IP owners
Us Patents
Method Of Determining The Three-Dimensional Shape Of A Macromolecule
US Patent:
7167819, Jan 23, 2007
Filed:
May 26, 2000
Appl. No.:
09/580380
Inventors:
Bradford W. Gibson - Berkeley CA, US
Irwin D. Kuntz - Greenbrae CA, US
Ning Tang - San Francisco CA, US
Gavin Dollinger - San Francisco CA, US
Connie M. Oshiro - Mountain View CA, US
Judith C. Hempel - San Francisco CA, US
Eric W. Taylor - Oakland CA, US
Malin Young - Newark CA, US
Irwin D. Kuntz - Greenbrae CA, US
Ning Tang - San Francisco CA, US
Gavin Dollinger - San Francisco CA, US
Connie M. Oshiro - Mountain View CA, US
Judith C. Hempel - San Francisco CA, US
Eric W. Taylor - Oakland CA, US
Malin Young - Newark CA, US
Assignee:
Chiron Corporation - Emeryville CA
The Regents of the University of California - Oakland CA
The Regents of the University of California - Oakland CA
International Classification:
G06G 7/58
G01N 31/00
G01N 24/00
G12P 19/42
G01N 31/00
G01N 24/00
G12P 19/42
US Classification:
703 12, 702 27, 435 86, 436173
Abstract:
The present invention provides a fast and efficient method for determining the three-dimensional conformation of a protein. The steps of the method of the invention include: 1) formation of physical distance constraints, e. g. , forming intramolecular chemical crosslinks of known size between residues of a protein; 2) enriching the number of the molecules that have intramolecular chemical crosslinks in the reaction pool, e. g. , using size separation to remove proteins with intermolecular bonds; 3) exposing the enriched reaction pool to a protease that cuts the protein at specific sites to produce peptide fragments; 4) measuring the size of the peptide fragments to determine linkage sites with a certain spatial relationship in the protein; and 5)interpreting the data produced to determine spatial geometry and protein structure based on the deduced spatial relationship of the linkage sites. The information is preferably analyzed with aid from a computer system, which can be used to generate and/or analyze distance constraints between amino acids.
Heterocyclic Derivatives As Inhibitors Of Purine Salvage Phosphoribosyltransferases
US Patent:
6075044, Jun 13, 2000
Filed:
Jul 17, 1998
Appl. No.:
9/118451
Inventors:
Ching C. Wang - San Francisco CA
John Somoza - San Francisco CA
Jon P. Page - San Francisco CA
Ronaldus Marcellus Alphonsus Knegtel - Nbijmegen, NL
Irwin D. Kuntz - Greenbrae CA
Connie M. Oshiro - Mountain View CA
A. Geoffrey Skillman - San Francisco CA
John Somoza - San Francisco CA
Jon P. Page - San Francisco CA
Ronaldus Marcellus Alphonsus Knegtel - Nbijmegen, NL
Irwin D. Kuntz - Greenbrae CA
Connie M. Oshiro - Mountain View CA
A. Geoffrey Skillman - San Francisco CA
Assignee:
The Regents of the University of California - San Francisco CA
International Classification:
A01N 4338
US Classification:
514415
Abstract:
The use of certain heterocyclic derivatives for treating parasitic protozoa infections in mammals, in particular bovine trichomoniasis and giardiasis, is disclosed.
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