Daniel Richard Baird, 37Export, PA

8180421, May 15, 2012

Dec 12, 2007

11/954848

Erica M. Phillips - Woodstock GA, US
Richard Hantke - Chicago IL, US
Daniel Baird - Woodstock GA, US
Mike Rainone - Palestine TX, US
Thomas Edward Plowman - Cary NC, US
Talbot Presley - Palestine TX, US

Kimberly-Clark Worldwide, Inc. - Neenah WI

A61B 5/1455
G01N 21/00

600310, 600317, 600342, 422 8211

Disclosed herein are methods and devices for detection of hospital acquired infections. Disclosed methods may be utilized for continuous in vivo monitoring of a potential infection site or for periodic in vitro monitoring of tissue or fluid from a patient and may be utilized to alert patients and/or health care providers to the presence of a pathogen at an early stage of infection. Disclosed methods utilize fluorophore pairs that optically interact with one another according to Forster resonance energy transfer (FRET) or bioluminescence resonance energy transfer (BRET) mechanism. One member of the pair or a cofactor that interacts with an enzyme to form a member of the pair may be tethered to a device by a substrate that is specific for an enzyme expressed by a targeted pathogen. Upon interaction of the enzyme with the substrate, an optically detectable signal may be altered or initiated, detection of which may then provide information as to the existence of the pathogen at the site.

2009015, Jun 18, 2009

Dec 12, 2007

11/954881

Tameka Brown - Lilburn GA, US
Akosua Atta-Mensah - Bethesda MD, US
Daniel Baird - Woodstock GA, US
Richard Hantke - Chicago IL, US
Tod Hoover Shultz - Killingworth CT, US
Erica M. Phillips - Woodstock GA, US
Shawn R. Feaster - Duluth GA, US
Mike Rainone - Palestine TX, US
Thomas Edward Plowman - Cary NC, US
Talbot Presley - Palestine TX, US

Kimberly-Clark Worldwide, Inc. - Neenah WI

C12Q 1/70

435 5

Disclosed are methods and devices for continuous in vivo monitoring of a potential infection site. Disclosed devices may be utilized to alert patients and/or health care providers to the presence of a pathogen at an early stage of a hospital acquired infection, thereby providing for earlier intervention and improved recovery rates from bacterial infection. Disclosed methods utilize implantable devices for location at an in vivo site. The implantable device is held in conjunction with an optical fiber that detects and transmits an optically detectable signal generated in the presence of a pathogen. Upon generation of the emission, the optically detectable emission signal may be transmitted to a portable detection/analysis device. Analysis of the characteristics of the emission signal produced may be used to determine the presence or concentration of pathogens at the site of inquiry, following which real time information may be transmitted to medical personnel, for instance via a wireless transmission system.

2012014, Jun 7, 2012

Dec 19, 2007

11/959823

Erica M. Phillips - Woodstock GA, US
Richard Hantke - Chicago IL, US
Daniel Baird - Woodstock GA, US
Mike Rainone - Palestine TX, US
Thomas Edward Plowman - Cary NC, US
Talbot Presley - Palestine TX, US

KIMBERLY-CLARK WORLDWIDE, INC. - Neenah WI

A61B 5/1473

600345

Disclosed herein are methods and devices for detection of hospital acquired infections. Disclosed methods may be utilized for continuous in vivo monitoring of a potential infection site and may be utilized to alert patients and/or health care providers to changes in the local environment due to the presence of a pathogen at an early stage of infection. Disclosed methods utilize ion sensitive field effect transistors (ISFETs) to detect changes in ionic concentration at the site due to the presence of a pathogen, for instance at a surgical site. When a pathogen is present, the local ionic concentration, and hence the electrical characteristics of an ISFET may change, causing a detectable signal from the ISFET. An ISFET may be associated with a biological material such as an enzyme or a specific binding partner for an expression product of a pathogen to improve detection. Upon interaction of the expression product with the enzyme or the probe, the electrical characteristics of the ISFET may change, detection of which may then provide information as to the existence a pathogen at the site.

6298855, Oct 9, 2001

Oct 22, 1999

9/426922

Daniel Duncan Baird - Woodstock GA

Kimberly-Clark Worldwide, Inc. - Neenah WI

A61B 1900

128849

The present invention is directed toward a surgical drape having a base sheet including a primary fenestration and at least one secondary fenestration, the drape being suitable for use in surgical procedures having multiple surgical sites.