Inventors:
Gary Ashley - Alameda CA
Mark Burlingame - San Francisco CA
Christopher Carreras - Belmont CA
Daniel Santi - San Francisco CA
Assignee:
Kosan Biosciences, Inc. - Hayward CA
International Classification:
A61K 3170
Abstract:
The present invention provides novel macrolide compounds of the formulas wherein: R is hydroxyl or methoxy; R is selected from the group consisting of hydrogen, hydroxyl, halide, NH , OR , âwhere R is C -C alkyl, C -C alkenyl, C -C alkynyl, aryl or heteroaryl and R and R are each independently hydrogen, C -C alkyl, C -C alkenyl, C -C alkynyl, or aryl; R and R are each independently selected from the group consisting of hydrogen, C -C alkyl, C -C alkenyl, C -C alkynyl, aryl, alkylaryl, alkenylaryl, alkynylaryl or R and R together form a cycloalkyl or a cycloaryl moiety; R is hydrogen or methyl; R is hydrogen, hydroxyl, oxo, or together with R and the carbons to which they are attached form a cyclic carbonate; R is hydrogen, hydroxyl, OR where R is C -C alkyl, C -C alkenyl, C -C alkynyl, or together with R and the carbons to which they are attached form a cyclic carbonate; R is methyl, C -C alkyl, C -C alkenyl, C -C alkynyl, alkylaryl, alkenylaryl, alkynylaryl, amidoalkylaryl, amidoalkenylaryl, or amidoalkynylaryl; R is C -C alkyl, C -C alkenyl, C -C alkynyl, alkylaryl, alkenylaryl, alkynylaryl, amidoalkylaryl, amidoalkenylaryl, or amidoalkynylaryl; and, x is a single or a double bond.
