David S Broadwell, 52128 White Cap Ln, Garner, NC 27529

2002016, Nov 14, 2002

May 10, 2002

10/142602

David Broadwell - Fort Lauderdale FL, US
Gregg Pospisil - Oak Brook IL, US

The Sports Authority, Inc.

G09F015/00
G09F007/02

040/606000, 040/611000, 040/665000

A universal sign holder comprises a frame including a wall defining a hollow interior along which grooves are formed to receive and support a sign. The outer surfaces of the wall of the frame are formed with opposed channels which receive a multi-purpose adapter slidable within the channels to any position along the frame. The adapter mounts one end of a connector or post, the other end of which is connected to one of a number of individual fixtures each designed to mount to a particular type of merchandise display such as a rack, shelf, pegboard and the like.

2003015, Aug 21, 2003

Dec 17, 2001

10/024130

Donna Stevens - Hillsborough NC, US
John Rice - Pittsboro NC, US
Beth Nye - Morrisville NC, US
David Broadwell - Garner NC, US
Norman Glassbrook - Chapel Hill NC, US
Veeresh Sevala - Cary NC, US
John Crawford - Raleigh NC, US
Sandy Stewart - Durham NC, US

C12Q001/48
C07H021/04
C12Q001/26
C12N009/02
C12N009/10
C12P021/02
C12N005/04

435/015000, 435/193000, 435/025000, 435/069100, 435/189000, 435/320100, 435/419000, 536/023200

The cloning of a truncated Arabidopsis gene expressing squalene synthase, as well as the expression and purification of the squalene synthase, are described. Also described herein is a fluorescent assay using squalene synthase that is amenable to high-throughout use, particularly for studying the regulation of isoprenoid synthesis and identifying squalene synthase inhibitors and promoters. As the formation of squalene is stoichiometric with the depletion of NADPH, the activity of squalene synthase can be evaluated by following the NADPH concentration over time. Squalene synthase activity is determined by combining FPP, NADPH, squalene synthase and a magnesium ion cofactor to form a reaction mixture under conditions suitable for squalene formation, optionally in the presence of a compound being analyzed for its ability to inhibit or promote squalene synthase. The concentration of NADPH over time is determined by subjecting the reaction mixture to UV light and detecting fluorescent light emission.

2004001, Jan 29, 2004

Nov 20, 2002

10/300543

Norman Glassbrook - Chapel Hill NC, US
Stephanie Winfield - Raleigh NC, US
Christopher Beecher - Chapel Hill NC, US
Yasmin Ranasinghe - Southington CT, US
David Broadwell - Garner NC, US
Ioana Popa-Burke - Durham NC, US
Gordon Nye - Morrisville NC, US

C12Q001/68
G01N033/53
G06F019/00
G01N033/48
G01N033/50
G01N031/00

435/006000, 435/007100, 702/019000, 702/022000

The present invention provides methods and systems for organizing complex and disparate data. More specifically, the present invention provides methods and systems for organizing complex and disparate data into coherent data sets. Coherent data sets resulting from the methods and systems of the present invention serve as models for biological systems. Methods and systems for integrating data and creating coherent data sets are useful for numerous biological applications, such as, for example, determining gene function, identifying and validating drug and pesticide targets, identifying and validating drug and pesticide candidate compounds, profiling drug and pesticide compounds, producing a compilation of health or wellness profiles, determining compound site(s) of action, identifying unknown samples, and numerous other applications in the agricultural, pharmaceutical, forensic, and biotechnology industries.

2004001, Jan 29, 2004

Nov 20, 2002

10/300360

Stephanie Winfield - Raleigh NC, US
Norman Glassbrook - Chapel Hill NC, US
Yasmin Ranasinghe - Southington CT, US
David Broadwell - Garner NC, US
Ioana Popa-Burke - Durham NC, US
Gordon Nye - Morrisville NC, US
Christopher Beecher - Chapel Hill NC, US

G06F019/00
G01N031/00

702/022000

The present invention provides methods and systems for organizing complex and disparate data. More specifically, the present invention provides methods and systems for organizing complex and disparate data into coherent data sets. Coherent data sets resulting from the methods and systems of the present invention serve as models for biological systems. Methods and systems for integrating data and creating coherent data sets are useful for numerous biological applications, such as, for example, determining gene function, identifying and validating drug and pesticide targets, identifying and validating drug and pesticide candidate compounds, profiling drug and pesticide compounds, producing a compilation of health or wellness profiles, determining compound site(s) of action, identifying unknown samples, and numerous other applications in the agricultural, pharmaceutical, forensic, and biotechnology industries.