David D Colby, 64591 Lunns Way, Plymouth, MA 02360

7063789, Jun 20, 2006

Jan 9, 2004

10/754908

David M. Colby - Medford MA, US
Frederick K. Lesan - Encinitas CA, US
Alan M. Franks - San Diego CA, US
Chang-Li Hsieh - Carlisle MA, US
Anjan Kumar Mukherjee - Tulsa OK, US

Koch Membrane Systems, Inc. - Wilmington MA

B01D 63/10
B01D 63/12

21032185, 2103232, 2104934, 96 7, 96 9

A coupler for a spiral membrane filtration element having a spiral membrane enclosed within a rigid outerwrap includes a center support, a plurality of spokes extending outwardly from the center support, a circular rim coupled with the spokes, with the face of the rim being perpendicular to the axis of the overwrap. The rim includes a channel on its face for receiving a compressible seal, and a plurality of receptacles around its outer surface for joining two face-to-face adjacent couplers when a pair of aligned keepers is place in each receptacle. Exemplary embodiments of the coupler and filtration elements and filtration assemblies are provided, as well as an associated method.

7311830, Dec 25, 2007

Apr 14, 2006

11/404164

David M. Colby - Medford MA, US
Frederick K. Lesan - Encinitas CA, US
Alan M. Franks - San Diego CA, US
Chang-Li Hsieh - Carlisle MA, US
Anjan Kumar Mukherjee - Tulsa OK, US

Koch Membrane Systems, Inc. - Wilmington MA

B01D 63/10
B01D 63/12
B01D 61/00

21032176, 2103218, 21032185, 2103232, 2104034, 96 4, 96 7, 96 10

A coupler for a spiral membrane filtration element having a spiral membrane enclosed within a rigid outerwrap includes a center support, a plurality of spokes extending outwardly from the center support, a circular rim coupled with the spokes, with the face of the rim being perpendicular to the axis of the overwrap. The rim includes a channel on its face for receiving a compressible seal, and a plurality of receptacles around its outer surface for joining two face-to-face adjacent couplers when a pair of aligned keepers is placed in each receptacle. Exemplary embodiments of the coupler and filtration elements and filtration assemblies are provided, as well as an associated method.

7387731, Jun 17, 2008

Nov 21, 2005

11/284158

David M. Colby - Medford MA, US
Frederick K. Lesan - Encinitas CA, US
Alan M. Franks - San Diego CA, US
Chang-Li Hsieh - Carlisle MA, US
Anjan Kumar Mukherjee - Tulsa OK, US

Koch Membrane Systems, Inc. - Wilmington MA

B01D 63/10
B01D 63/12
B01D 61/00

21032185, 21032176, 2103232, 2104934, 96 7, 96 9, 285335, 285336

A coupler for a spiral membrane filtration element having a spiral membrane enclosed within a rigid outerwrap includes a center support, a plurality of spokes extending outwardly from the center support, a circular rim coupled with the spokes, with the face of the rim being perpendicular to the axis of the overwrap. The rim includes a channel on its face for receiving a compressible seal, and a plurality of receptacles around its outer surface for joining two face-to-face adjacent couplers when a pair of aligned keepers is place in each receptacle. Exemplary embodiments of the coupler and filtration elements and filtration assemblies are provided, as well as an associated method.

2005022, Oct 13, 2005

Nov 22, 2004

10/995074

David Colby - Cambridge MA, US
K. Wittrup - Chestnut Hill MA, US
Vernon Ingram - Cambridge MA, US

Massachusetts Institute of Technology - Cambridge MA

A61K039/395
C07K016/44

424132100, 530387300

The invention relates in part to methods of making single-domain antibodies and methods of using single-domain antibodies to diagnose and treat disease. The invention also relates to methods and products for modulating target protein activity, including methods to inhibit huntingtin protein aggregation in Huntington's disease. The invention also includes methods and compounds for identifying pharmaceutical agents for preventing and treating diseases and for monitoring the efficacy of treatments for target protein-associated diseases.

5470468, Nov 28, 1995

Oct 12, 1993

8/134062

David M. Colby - Medford MA

Koch Membrane Systems, Inc. - Wilmington MA

B01D 2708

2103216

A membrane filtration module is provided incorporating a seal assembly to seal the annular space or bypass channel existing between the outer diameter of the filtration cartridge and the inner diameter of the housing in which it is disposed. The seal assembly prevents a feed stream from entering the bypass channel, and includes a pair of seals each having a flexible gasket and a sleeve extending perpendicularly therefrom, the sleeve being adapted to be positioned directly on the cartridge. This positioning prevents the feed stream from ever coming into contact with the housing.