David Kew resumes & CV records
Resumes
David Kew
Location:
United States
David A Kew, 701 Barnard Rd, Worcester, MA 01605
David Kew Phones & Addresses
1 Barnard Rd, Worcester, MA 01605 508-8548221
84 Burncoat St, Worcester, MA 01605
Boylston, MA
Jamaica Plain, MA
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David A Kew
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Publications & IP owners
Us Patents
Compositions For Treating And/Or Preventing Diseases Characterized By The Presence Of Metal Ions
US Patent:
8273726, Sep 25, 2012
Filed:
Sep 25, 2009
Appl. No.:
12/567678
Inventors:
Orrie Friedman - Brookline MA, US
Ivan Correia - Winchester MA, US
Toby J. Sommer - Waltham MA, US
David Alan Kew - Worcester MA, US
Ivan Correia - Winchester MA, US
Toby J. Sommer - Waltham MA, US
David Alan Kew - Worcester MA, US
Assignee:
Brandeis University - Waltham MA
International Classification:
A01N 55/00
A61K 31/695
A61K 31/695
US Classification:
514 63
Abstract:
The present invention generally relates to the treatment and/or prevention of Alzheimer's disease, other neurodegenerative diseases, and/or diseases characterized by the presence of certain metal ions, by using certain compositions including organosilicon compounds. A composition of the invention may be administered to a mammal, such as a human. In some cases, the composition may include a silanol, a silandiol, a silantriol, or a cyclic organosilane, and/or be able to form a silanol, a silandiol, or a silantriol upon exposure to physiological conditions such as are found in the blood, in the stomach and/or gastrointestinal tract, or in the brain or other organ. In certain cases, the organosilicon compound may be bound to a moiety able to be transported across the blood-brain barrier into the brain, for example, an amino acid, a peptide, a protein, a virus, etc. The organosilicon compound may also be labeled (e. g. , fluorescently or radioactively) in certain instances.
Compositions For Treating And/Or Preventing Diseases Characterized By The Presence Of Metal Ions
US Patent:
2006004, Feb 23, 2006
Filed:
May 17, 2005
Appl. No.:
11/132170
Inventors:
Orrie Friedman - Brookline MA, US
Ivan Correia - Winchester MA, US
Toby Sommer - Waltham MA, US
David Kew - Worcester MA, US
Ivan Correia - Winchester MA, US
Toby Sommer - Waltham MA, US
David Kew - Worcester MA, US
International Classification:
A61K 31/695
US Classification:
514063000
Abstract:
The present invention generally relates to the treatment and/or prevention of Alzheimer's disease, other neurodegenerative diseases, and/or diseases characterized by the presence of certain metal ions, by using certain compositions including organosilicon compounds. A composition of the invention may be administered to a mammal, such as a human. In some cases, the composition may include a silanol, a silandiol, a silantriol, or a cyclic organosilane, and/or be able to form a silanol, a silandiol, or a silantriol upon exposure to physiological conditions such as are found in the blood, in the stomach and/or gastrointestinal tract, or in the brain or other organ. In certain cases, the organosilicon compound may be bound to a moiety able to be transported across the blood-brain barrier into the brain, for example, an amino acid, a peptide, a protein, a virus, etc. The organosilicon compound may also be labeled (e.g., fluorescently or radioactively) in certain instances. In some embodiments, the composition, or a portion thereof, may sequester aluminum, copper, iron or other ions, for example, by electrostatically binding to the ions. The composition may also include other functionalities such as amines, certain alkyl and/or aryl moieties (including substituted alkyls and/or aryls), or hydrophobic moieties, for example, to facilitate transport of the organosilicon compound through the blood-brain barrier.
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