David StephensSan Jose, CA

6403306, Jun 11, 2002

Sep 23, 1997

08/936107

David S. Stephens - Stone Mountain GA
John S. Swartley - Westport CT

Emory University - Atlanta GA

C12Q 168

435 6, 536 237, 536 243, 536 2432, 4353201, 435975

The present invention is based on the discovery of meningococcal isolates having genetic markers of a particular serogroup but expressing a capsular polysaccharide of a different serogroup. These isolates and prototype serogroup A, B, C, Y and W-135 strains were used to define the capsular biosynthetic operon of the major meningococcal serogroups and to show that capsule switching occurs as a result of allelic exchange of, for example, the polysialyl-transferase gene. Findings of capsule switching in vivo indicate that closely related virulent meningococcal clones may not be recognized by traditional serogroup-based surveillance and can escape vaccine-induced or natural protective immunity by capsule switching. The invention provides recombinant meningococcal strains, recombinant DNA constructs and immunological preparations useful as diagnostic probes for detection and diagnosis of meningococcal diseases, screening for specific meningococcal serogroups and broad based immunizations with multivalent capsular polysaccharide conjugate vaccines.

6472518, Oct 29, 2002

Aug 17, 1999

09/284926

Efrain M. Ribot - Atlanta GA
David S. Stephens - Stone Mountain GA
Nigel Raymond - Wellington, NZ
Frederick D. Quinn - Avondale Estates GA

Centers for Disease Control and Prevention, as represented by the Secretary, Department of Health and Human Services - Atlanta GA

C07H 2104

536 237, 536 2432, 536 2433, 536 241, 4242501, 435243, 4352523, 4353201, 435 691, 435 693

Genes isolated from , as well as isolated nucleic acids, probes, expression cassettes, polypeptides, antibodies, immunogenic compositions, antisense nucleic acids, amplification mixtures, and new invasion deficient swains of are provided Methods of detecting and nucleic acids, and methods of inhibiting the invasion of mammalian cells by are also provided.

7348161, Mar 25, 2008

Mar 15, 2002

10/472801

Kathryn Gay - Atlanta GA, US
David S. Stephens - Stone Mountain GA, US

Emory University - Atlanta GA

C12Q 1/37
C12Q 1/14
C07K 14/325
C12N 1/20

435 237, 530350, 43525233, 435 72, 435 32

Macrolide resistance associated with macrolide efflux (mef) in has been defined with respect to the genetic structure and dissemination of a novel mefE-containing chromosomal insertion element. The mefE gene is found on the 5′-end of a 5. 5 kb or 5. 4 kb insertion designated mega (acrolide fflux enetic ssembly) found in at least four distinct sites of the pneumococcal genome. The element is transformable and confers macrolide resistance to susceptible. The first two open reading frames (ORFs) of the element form an operon composed of mefE and a predicted ATP-binding cassette homologous to msrA. Convergent to this efflux operon are three ORFs with homology to stress response genes of Tn5252. Mega is related to mefA-containing element Tn1207. 1. Macrolide resistance due to mega has been rapidly increased by clonal expansion of bacteria containing it and horizontally by transformation of previously sensitive bacteria.

7497819, Mar 3, 2009

Mar 6, 2007

11/682681

Jack C. White - Alpharetta GA, US
David Wesley Stephens - Cornelia GA, US
Amit Prakash Govil - Gainesville FL, US
Joshua J. Bergman - Myrtle Point OR, US
Nathan Christopher Griffith - Lawrenceville GA, US
Kyle Kevin Millage - Flemington NJ, US

Theragenics Corporation - Buford GA

A61N 5/00

600 3

A brachytherapy device for the provision of brachytherapy is disclosed. The brachytherapy device has at least one source lumen located outside a movable surface of the device. The source lumen may be secured to the movable outer surface in a manner whereby relative movement of the source lumen relative to the movable outer surface is permitted. The brachytherapy device is inserted into a body cavity. After insertion, the movable surface is moved to position the at least one source lumen closer to the tissue boundary of the cavity. One or more sources of radiation are then placed within the at least one source lumen to provide a customizable treatment. Also disclosed are methods for providing brachytherapy via body cavities.

7497820, Mar 3, 2009

Mar 19, 2007

11/688033

Jack C. White - Alpharetta GA, US
David Wesley Stephens - Cornelia GA, US
Amit Prakash Govil - Gainesville FL, US
Joshua J. Bergman - Myrtle Point OR, US
Nathan Christopher Griffith - Lawrenceville GA, US
Kyle Kevin Millage - Flemington NJ, US

Theragenics Corporation - Buford GA

A61N 5/00

600 3

A brachytherapy device for the provision of brachytherapy is disclosed. The brachytherapy device has at least one source lumen located outside a movable surface of the device. The source lumen may be secured to the movable outer surface in a manner whereby relative movement of the source lumen relative to the movable outer surface is permitted. The brachytherapy device is inserted into a body cavity. After insertion, the movable surface is moved to position the at least one source lumen closer to the tissue boundary of the cavity. One or more sources of radiation are then placed within the at least one source lumen to provide a customizable treatment. Also disclosed are methods for providing brachytherapy via body cavities.

7662082, Feb 16, 2010

Nov 4, 2005

11/266994

Jack C. White - Alpharetta GA, US
David Wesley Stephens - Cornelia GA, US
Amit Prakash Govil - Gainesville FL, US
Joshua J. Bergman - Myrtle Point OR, US
Nathan Christopher Griffith - Lawrenceville GA, US
Kyle Kevin Millage - Flemington NJ, US

Theragenics Corporation - Buford GA

A61N 5/00

600 3

A brachytherapy device for the provision of brachytherapy is disclosed. The brachytherapy device has at least one source lumen located outside a movable surface of the device. The source lumen may be secured to the movable outer surface in a manner whereby relative movement of the source lumen relative to the movable outer surface is permitted. The brachytherapy device is inserted into a body cavity. After insertion, the movable surface is moved to position the at least one source lumen closer to the tissue boundary of the cavity. One or more sources of radiation are then placed within the at least one source lumen to provide a customizable treatment. Also disclosed are methods for providing brachytherapy via body cavities.

7807181, Oct 5, 2010

Mar 20, 2003

10/508309

David S. Stephens - Stone Mountain GA, US
Yih-Ling Tzeng - Atlanta GA, US
Susu Zughaier - Atlanta GA, US
Shanta Zimmer - Atlanta GA, US

Emory University - Atlanta GA

A61K 39/02
A61K 39/095
A61K 39/38
A01N 43/04
C07H 1/00

4242341, 4241841, 4242501, 4242491, 514 23, 5361231

Provided herein are mutant strains of which produce Kdo-free lipid A as well as the Kdo-free lipid A molecules and immunogenic compositions containing such Kdo-free lipid A molecules from a strain containing a genetically stable mutation which inactivates a gene selected from the group consisting of genes encoding arabinose-5-phosphate isomerase, CMP-Kdo synthetase and CMP-Kdo transferase. NMB206 is a specifically exemplified strain which harbors a stable insertion mutation in the gene (kpsF) encoding A5P isomerase; strain NMB-249 is a specifically exemplified strain with a stable insertion mutation in the gene (kdtA) encoding CMP-Kdo synthetase, and strain NMB259 is specifically exemplified strain with a stable insertion mutation in the gene (kdsB) encoding CMP-Kdo transferase. Also provided by the present invention are methods for the production of Lipid A flee of 3-keto-3-deoxyoctanoic acid using these genetically stable mutants. Also describes is pYT250, a plasmid functional in neisseriae and in enterics such as.

7818683, Oct 19, 2010

Dec 6, 2004

11/005628

Alexander Aaron Sorin - Scotts Valley CA, US
David R. Stephens - Half Moon Bay CA, US
Daniel Schwartz - New York NY, US

Oracle International Corporation - Redwood Shores CA

G06F 3/048
G06F 3/00

715768, 715854

A method of a navigational path includes enabling a user to successively display a plurality of web pages; maintaining a full breadcrumb path that includes a link to each of the previously displayed pages; displaying a shortened breadcrumb path on a current page, the shortened breadcrumb path including fewer links than the full breadcrumb path, and displaying the full breadcrumb path only upon request. A method of representing a current location within a hierarchical structure of a web site or web application includes maintaining a hierarchical map of the web site or web application; generating a web page that has a predetermined level within the hierarchical map; displaying a hierarchical structure selector on the web page, and when the displayed hierarchical structure selector is selected by a user, displaying an indication of the predetermined level and a link to each hierarchically higher level of the generated web page.