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David A Weisgerber, 8753 Beachwood Ct, Crossville, TN 38558

Known as:
Dave A Weisgerber David A Horner David A Er Davi Weisgerber David R Weisgerber Davi
Related to:
Brittany Marie Walton 34

David Weisgerber Phones & Addresses

53 Beachwood Ct, Crossville, TN 38558    931-4840260    931-4566103   

3250 Peavine Rd, Crossville, TN 38558    931-4840260   

333 E Butterfield Rd, Lombard, IL 60148   

Lorain, OH   

24 Wildwood Dr, Fairfield, OH 45014    513-4840260   

Cincinnati, OH   

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Career records & work history

Medicine Doctors

David W. Weisgerber

Specialties:
Internal Medicine
Work:
David W Weisgerber MD
307 10 Ave NE, Hickory, NC 28601
828-3279898 (phone)
Education:
Medical School
University of Toledo College of Medicine
Graduated: 1981
Procedures:
Arthrocentesis, Cardiac Stress Test
Conditions:
Atrial Fibrillation and Atrial Flutter, Pneumonia, Acne, Acute Bronchitis, Acute Pharyngitis, Acute Renal Failure, Acute Sinusitis, Acute Upper Respiratory Tract Infections, Anxiety Phobic Disorders, Bacterial Pneumonia, Bronchial Asthma, Diabetes Mellitus (DM), Disorders of Lipoid Metabolism, Emphysema, Erectile Dysfunction (ED), Fractures, Dislocations, Derangement, and Sprains, Gastroesophageal Reflux Disease (GERD), Gastrointestinal Hemorrhage, Gout, Heart Failure, Hypertension (HTN), Hypothyroidism, Iron Deficiency Anemia, Ischemic Heart Disease, Menopausal and Postmenopausal Disorders, Migraine Headache, Osteoarthritis, Osteoporosis, Urinary Tract Infection (UT), Venous Embolism and Thrombosis, Vitamin D Deficiency
Languages:
English
Description:
Dr. Weisgerber graduated from the University of Toledo College of Medicine in 1981. He works in Hickory, NC and specializes in Internal Medicine. Dr. Weisgerber is affiliated with Frye Regional Medical Center.

David Weisgerber resumes & CV records

Resumes

David Weisgerber Photo 28

David Weisgerber

David Weisgerber Photo 29

David Weisgerber

Location:
United States

Publications & IP owners

Us Patents

Personal Care Compositions Containing Active Proteins Tethered To A Water Insoluble Substrate

US Patent:
6410017, Jun 25, 2002
Filed:
Sep 22, 1999
Appl. No.:
09/401093
Inventors:
David John Weisgerber - Cincinnati OH
Andrew Campbell Allcock - Cincinnati OH
Assignee:
The Procter Gamble Company - Cincinnati OH
International Classification:
A61K 3843
US Classification:
424 941, 424 9463, 424 946, 424 943, 424443
Abstract:
The present invention relates to personal care compositions comprising a water insoluble substrate, a plurality of active proteins, and a binding means, comprising a polymeric tether, permanently attaching each of the enzymes to the substrate wherein the personal care composition comprises from about 0. 01 g/cm to about 1000 g/cm of the enzyme on the substrate.

Proteases Having Modified Amino Acid Sequences Conjugated To Addition Moieties

US Patent:
6495136, Dec 17, 2002
Filed:
Jun 2, 1998
Appl. No.:
09/088912
Inventors:
David John Weisgerber - Cincinnati OH
Donn Nelton Rubingh - Cincinnati OH
Paul Elliott Correa - Cincinnati OH
Assignee:
The Procter Gamble Company - Cincinnati OH
International Classification:
A61K 3848
US Classification:
424 9464, 424401, 424 701, 424 9463, 435177, 435178, 435180, 435188, 435219, 435221, 510392
Abstract:
Protease conjugates such as subtilisin conjugates are provided comprising a protease moiety and one or more addition moieties wherein the protease moiety has a modified amino acid sequence of a parent amino acid sequence. The parent amino acid sequence comprises a first epitope region, a second epitope region and a third epitope region, and the modified amino acid sequence comprises a substitution by a substituting amino acid at one or more positions in one or more of the epitope regions. When a substitution occurs in the first epitope region, the substitution occurs at one or more positions corresponding to positions 70-84 of subtilisin BPNâ. When a substitution occurs in the second epitope region, the substitution occurs at one or more positions corresponding to positions 103-126 of subtilisin BPNâ. When a substitution occurs in the third epitope region, the substitution occurs at one or more positions corresponding to positions 217-252 of subtilisin BPNâ. Each addition moiety is covalently attached to one of the substituting amino acids.

Protease Conjugates Having Sterically Protected Clip Sites

US Patent:
6566115, May 20, 2003
Filed:
Jul 18, 2000
Appl. No.:
09/618740
Inventors:
David John Weisgerber - Cincinnati OH
Donn Nelton Rubingh - Cincinnati OH
Paul Elliott Correa - Cincinnati OH
Assignee:
The Procter Gamble Company - Cincinnati OH
International Classification:
C12N 954
US Classification:
435221, 435 691, 435222, 4352523, 4353201, 435471, 510350, 524267, 536 232
Abstract:
The present disclosure relates to subtilisin protease conjugate comprising a protease moiety and one or more addition moieties. Each addition moiety is covalently attached to a clip site protection position of the protease moiety, wherein the clip site protection positions are selected from 13, 14, 15, 16, 18, 19, 20, 21, 84, 85, 88, 158, 159, 160, 161, 162, 163, 164, 165, 170, 186, 191, 192, 193, 194, 196, 259, 260, 261, 262, and 274 corresponding to subtilisin BPNâ. The protease conjugates have decreased immunogenicity relative to a parent protease. The present disclosure further relates to cleaning and personal care compositions comprising the protease conjugates.

Protease Conjugates Having Sterically Protected Epitope Regions

US Patent:
6946128, Sep 20, 2005
Filed:
Jul 18, 2000
Appl. No.:
09/618235
Inventors:
Donn Nelton Rubingh - Cincinnati OH, US
David John Weisgerber - Cincinnati OH, US
Paul Elliott Correa - Cincinnati OH, US
Assignee:
The Procter & Gamble Company - Cincinnati OH
International Classification:
A61K038/48
C12N009/96
C12N009/52
C12S009/00
C12S011/00
US Classification:
424 9464, 4241931, 435188, 435220, 435221, 435222, 510300, 510392
Abstract:
The present disclosure relates to subtilisin protease conjugate comprising a protease moiety and one or more addition moieties. Each addition moiety is covalently attached to an epitope protection position of the protease moiety. The protease conjugates have decreased immunogenicity relative to a parent protease. The present disclosure further relates to cleaning and personal care compositions comprising the protease conjugates.

Topical Skin Care Compositions Containing Thickened Polyol Carboxylic Acid Esters As Skin Conditioning Agents

US Patent:
2002003, Apr 4, 2002
Filed:
Apr 7, 1997
Appl. No.:
08/838467
Inventors:
Darrell Doughty - Cincinnati OH, US
Joseph Gatto - Cincinnati OH, US
David Weisgerber - Cincinnati OH, US
James Schwartz - Chester OH, US
International Classification:
A61K007/42
A61K007/44
C07H013/02
A61K031/7024
US Classification:
424/059000, 424/060000, 514/023000, 536/119000
Abstract:
The present invention relates to skin care compositions comprising a skin conditioning agent and a topical carrier for the skin conditioning agent. The skin conditioning agent comprises certain nonocclusive liquid polyol carboxylic acid esters, wherein the liquid polyester has a complete melting point of less than about 30 C., and certain solid polyol carboxylic acid ester thickeners for the liquid polyester, wherein the solid polyester has a complete melting point of greater than about 30 C. These compositions provide excellent skin conditioning benefits.

Compositions Containing Enzymes Stabilized With Inhibitors Having Certain Binding Properties And Methods For Using Such Compositions In Personal Care

US Patent:
2003015, Aug 21, 2003
Filed:
Nov 12, 2002
Appl. No.:
10/293100
Inventors:
Russell Elliott - Egham, GB
Charles Saunders - Fairfield OH, US
David Weisgerber - Cincinnati OH, US
Assignee:
The Proctor & Gamble Company - Cincinnati OH
International Classification:
A61K038/48
US Classification:
424/094640, 424/094630
Abstract:
Leave-on personal care compositions comprising a stabilized enzyme, at least 30% water, less than 5% of an earth alkali metal salt, and an enzyme inhibitor having an inhibition constant (K) from 10 nanomolar (nM) to 25,000 nM. Also, a method of providing a skin care benefits, e.g. skin feel and/or skin appearance, preferably skin moisturization, skin softness, and/or skin smoothness, comprising topically applying a safe and effective amount of the inventive compositions described herein to skin in need of such a skin care benefit. Further, a method of providing a consumer with a leave-on enzyme-containing personal care product, wherein the enzyme is inhibited and inactive on shelf, but is active on skin without the need for a separate re-activation step, preferably wherein the leave-on enzyme-containing personal care product comprises a one of the inventive compositions described herein.

Enzyme Variants Having One Or More D-Amino Acid Substitutions

US Patent:
2003017, Sep 11, 2003
Filed:
Apr 2, 2001
Appl. No.:
09/824607
Inventors:
David Weisgerber - Cincinnati OH, US
International Classification:
C12N009/02
C12N009/10
C12N009/14
C12N009/24
C12N009/48
US Classification:
435/193000, 435/195000, 435/189000, 435/200000, 435/212000
Abstract:
The present invention relates to enzyme variants having decreased immunogenicity relative to their corresponding wild-type enzymes. More particularly, the present invention relates to enzyme variants having a modified amino acid sequence of a wild-type amino acid sequence, wherein the modified amino acid sequence comprises a substitution of one or more amino acid positions with at least one D-amino acid. The invention further relates to mutant genes encoding such enzyme variants and cleaning and personal care compositions comprising such enzyme variants.

Cosmetic Method

US Patent:
2003020, Nov 6, 2003
Filed:
Mar 12, 2003
Appl. No.:
10/388018
Inventors:
Conor O'Prey - Richmond, GB
Marina Trani - Ascot, GB
David Weisgerber - Cincinnati OH, US
International Classification:
A61K038/48
C12N009/50
A61K031/525
A61K031/07
US Classification:
424/094630, 514/250000, 514/251000, 514/725000, 435/219000
Abstract:
A cosmetic method for providing improved skin hydration is provided comprising the steps of topically applying to the skin a protease enzyme, and simultaneously or sequentially, topically applying to the skin a polyhydric alcohol. Also provided is a cosmetic method for providing improved skin hydration comprising topically applying to the skin a polyhydric alcohol, and simultaneously or sequentially, topically applying to the skin a protease enzyme.

Possible Relatives

Dominick B Weisgerber  Frank Weisgerber  George Weisgerber  Gregory L Weisgerber  Helen M Weisgerber  Adam J Weisgerber  James E Weisgerber  David Last  David W Johnson  David Stamps 

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