David A Whitten, 732775 Butch Cassidy Dr SW, Albuquerque, NM 87121

7122383, Oct 17, 2006

Mar 18, 2002

10/098387

Robert M. Jones - Albuquerque NM, US
Sriram Kumaraswamy - Santa Fe NM, US
Liangde Lu - Mesa AZ, US
Frauke Rininsland - Santa Fe NM, US
Kevin Ley - Santa Fe NM, US
Wensheng Xia - Santa Fe NM, US
Duncan McBranch - Santa Fe NM, US
David G. Whitten - Santa Fe NM, US

QTL Biosystems, LLC - Santa Fe NM

G01N 33/543

436518, 435 6, 435 71, 435 772, 435 911, 436172, 436501, 436 94, 536 231

A chemical composition including a fluorescent polymer and a receptor that is specific for both a target biological agent and a chemical moiety including (a) a recognition element, (b) a tethering element, and (c) a property-altering element is disclosed. Both the fluorescent polymer and the receptor are co-located on a support. When the chemical moiety is bound to the receptor, the property-altering element is sufficiently close to the fluorescent polymer to alter the fluorescence emitted by the polymer. When an analyte sample is introduced, the target biological agent, if present, binds to the receptor, thereby displacing the chemical moiety from the receptor, resulting in an increase of detected fluorescence. Assays for detecting the presence of a target biological agent are also disclosed.

8455265, Jun 4, 2013

Feb 29, 2008

12/529390

David G. Whitten - Albuquerque NM, US
Sireesha Chemburu - Albuquerque NM, US
Thomas Corbitt - Albuquerque NM, US
Linnea Ista - Albuquerque NM, US
Gabriel Lopez - Albuquerque NM, US
Kirk S. Schanze - Gainesville FL, US
Motokatsu Ogawa - Sherman Oaks CA, US
Eunkyung Ji - Albuquerque NM, US

STC.UNM - Albuquerque NM

G01N 33/552
G01N 33/543

436527, 422 8205, 422 8206, 422 8207, 422 8208, 436 85, 436 86, 436 87, 436 88, 436 89, 436 90, 436 91, 436 92, 436 93, 436 94, 436 95, 436 96, 436 97, 436 98, 436166, 436172, 436518, 436523, 436524, 436525, 436526, 436528, 436529, 436530, 436531

A surface grafted conjugated polyelectrolyte (CPE) is formed by coupling a CPE by a coupling moiety to the surface of a substrate. The substrate can be of any shape and size, and for many uses of the surface grafted CPE, it is advantageous that the substrate is a nanoparticle or microparticle. Surface grafted CPEs are presented that use silica particles as the substrate, where a modified silane coupling agent connects the surface to the CPE by a series of covalent bonds. Two methods of preparing the surface grafted CPEs are presented. One method involves the inclusion of the surface being modified by the coupling agent and condensed with monomers that form the CPE in a grafted state to the substrate. A second method involves the formation of a CPE with terminal groups that are complimentary to functionality that has been placed on the surface of the substrate by reaction with a coupling agent. The surface grafted CPEs are also described for use as biosensors and biocides.

8598053, Dec 3, 2013

Oct 12, 2010

13/503067

David G. Whitten - Albuquerque NM, US
Linnea K. Ista - Albuquerque NM, US
Thomas S. Corbitt - Albuquerque NM, US
Motokatsu Ogawa - Gainesville FL, US
Kirk S. Schanze - Gainesville FL, US
Gabriel P. Lopez - Durham NC, US
Ramanathan Nagarajan - Natick MA, US

STC.UNM - Albuquerque NM

B32B 5/02

442123, 442 59, 527313

The present disclosure describes the manufacture and use of soft surfaces such as fabrics bearing surface-grafted antimicrobial polymers.

8618009, Dec 31, 2013

Nov 9, 2009

13/128571

Kirk S. Schanze - Gainesville FL, US
Motokatsu Ogawa - Sherman Oaks CA, US
Jonathan R. Sommer - Gainesville FL, US
David G. Whitten - Albuquerque NM, US
Thomas Corbitt - Albuquerque NM, US

STC.UNM - Albuquerque NM

A61L 2/00
H01B 1/04
B01J 35/08
A01N 25/34

502 8, 422 22, 422 28, 252503, 252508, 977712, 977903, 510349, 426 89, 424490, 424408, 428402

Hollow conjugated polyelectrolyte (HCPE) microcapsules contain at least one conjugated polyelectrolyte and at least one other polyelectrolyte of complementary charge and the microcapsule has a hollow core. The conjugated polyelectrolyte is a polymer with a multiplicity of charged repeating units where a portion of the charged repeating units form a pi-conjugated sequence. The complementary polyelectrolyte is a polymer with a complementary charged repeating unit to the charged repeating units of the conjugated polyelectrolyte. The HCPE microcapsules can be formed by successively coating a sacrificial core with alternating layers of complementary polyelectrolytes, at least one of which is a conjugated polyelectrolyte. The sacrificial core can be removed to form the hollow center of a HCPE microcapsule. The HCPE microcapsules can be contacted with a medium containing microbes where the HCPE microcapsules associate with the microbes and efficiently kill the microbes when irradiated with light or other electromagnetic radiation.

2004017, Sep 9, 2004

Nov 14, 2003

10/712004

Stuart Kushon - Santa Fe NM, US
Sriram Kumaraswamy - Santa Fe NM, US
Wensheng Xia - Albuquerque NM, US
Robert Jones - Albuquerque NM, US
Kevin Ley - Santa Fe NM, US
Duncan McBranch - Santa Fe NM, US
David Whitten - Albuquerque NM, US

C12M001/34
G01N033/53
B05D003/00

435/007500, 435/287200, 427/002110

Complexes of a biotinylated fluorescent polymer and a biotin binding protein and solid supports coated with the fluorescent polymer complexes are described. The complexes can be used as sensors for detecting biological recognition events (e.g., nucleic acid hybridization reactions or enzymatic induced polypeptide cleavage). Methods of making the complexes and methods of using the complexes for detecting the presence and/or amount of a target analyte in a sample are also described. The target analyte can be an enzyme (e.g., -secretase) or a nucleic acid (e.g., a single stranded or double stranded nucleic acid).

2005001, Jan 20, 2005

Jul 18, 2003

10/621311

Sriram Kumaraswamy - Santa Fe NM, US
Komandoor Achyuthan - Santa Fe NM, US
Xiaobo Shi - Los Alamos NM, US
Troy Bergstedt - Cochiti NM, US
Frauke Rininsland - Santa Fe NM, US
Duncan McBranch - Santa Fe NM, US
David Whitten - Albuquerque NM, US

C12Q001/68
G01N033/53
C07H021/04

435006000, 435007500, 530391100, 536025320

Bioconjugates, kits and assays for detecting the activity of protease enzymes such as β-secretase and caspase enzymes are described. The bioconjugates include a tether having a segment capable of recognizing and interacting with (e.g., being cleaved by) the enzyme, a fluorescer including a plurality of fluorescent species conjugated to a first location on the tether, and a quencher conjugated to a second location on the tether. The segment capable of recognizing and interacting with the protease enzyme (e.g., β-secretase or caspase) is located between the first and second locations on the tether. The plurality of fluorescent species are associated with one another such that the quencher is capable of amplified super-quenching of the fluorescer. The assay is suitable for screening potential drugs for their efficiency in inhibiting the activity of protease enzymes such as β-secretase in a high throughput format where the potential drugs are evaluated.

2005011, Jun 2, 2005

Sep 21, 2004

10/945097

Wensheng Xia - Santa Fe NM, US
David Whitten - Albuquerque NM, US
Duncan McBranch - Santa Fe NM, US

C12Q001/68
G01N033/53
C07D043/02

435006000, 534727000, 534770000, 435007100

Non-fluorescent dyes (i.e., dark quenchers) which can be used to quench the fluorescence of energy donors in bioassays through fluorescence resonance energy transfer (FRET) are described. The dark quenchers can be associated with (e.g., conjugated to) peptides, proteins, antibodies, DNA/RNA, or other biological molecules or receptors or complexed to metal containing compounds to develop bioassays based on donor-acceptor energy transfer. Bioassays are also described wherein an increase or a decrease in separation distance between a fluorescent donor compound and a dark quencher or dark quencher conjugate is detected. Kits including the dark quenchers or dark quencher conjugates are also described.

2005014, Jul 7, 2005

Dec 16, 2004

11/012187

Liangde Lu - Albuquerque NM, US
Frauke Rininsland - Santa Fe NM, US
Shannon Wittenburg - Santa Fe NM, US
Komandoor Achyuthan - Santa Fe NM, US
Duncan McBranch - Santa Fe NM, US
David Whitten - Albuquerque NM, US

B32B005/02

442123000

Compositions including biocidal reagents and articles treated or coated therewith are described. The compositions can be used to make passive biocidal surfaces. Exemplary biocidal reagents include visible light-absorbing polyelectrolytes which act as passive biocides upon exposure to radiation, including relatively weak “background” radiation such as natural light sources (e.g., indirect sunlight) and artificial light sources. Methods of treating or coating surfaces with the compositions are also described.