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Dmitry A Samarsky, 5815 Wayside Rd, Westborough, MA 01581

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Y Y Dmitry Y

Dmitry Samarsky Phones & Addresses

Westborough, MA   

Boulder, CO   

31 Fales St, Worcester, MA 01606    508-8569288   

Enola, PA   

Amherst, MA   

Bolton, MA   

Carlsbad, CA   

Belchertown, MA   

Daleville, IN   

15 Wayside Rd, Westborough, MA 01581   

Education

Degree: High school graduate or higher
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Mentions for Dmitry A Samarsky

Dmitry Samarsky resumes & CV records

Resumes

Dmitry Samarsky Photo 3

Director, Technology Development

Location:
Denver, CO
Industry:
Biotechnology
Work:
Thermo Fisher Scientific
Director, Technology Development
Education:
Ivan Franko National University of Lviv 1983 - 1990
National University 'Ivan Franko'​
Dmitry Samarsky Photo 4

Chief Technology Officer

Location:
San Francisco, CA
Industry:
Biotechnology
Work:
Silence Therapeutics 2016 - 2018
Chief Scientific Officer Sirnaomics 2016 - 2018
Chief Technology Officer Oligonucleotide Therapeutics Society 2016 - 2018
Scientific Council Member Transcode Therapeutics 2016 - 2018
Scientific Advisory Board Member Ribobio 2011 - 2016
Senior Vice President, Technology and International Business Development Canton Nucleic Acids Forum (Cnaf) 2011 - 2016
Scientific Council Member Rbv Capital 2011 - 2016
Scientific Advisory Board Member Knect365 Life Sciences (Formerly Ibc Life Sciences) 2011 - 2016
Scientific Advisory Board Member Rxi Pharmaceuticals Corporation 2007 - 2011
Vice President, Technology and Business Development Thermo Fisher Scientific 2005 - 2007
Director, Technology Development Allied Academies 2005 - 2007
Distinguished Editorial Board Member, Journal of Rna and Genomics Life Technologies 2003 - 2005
Manager, Business Development Life Technologies 2001 - 2003
Director, Technology and Business Development University of Massachusetts 1993 - 2001
Graduate + Post-Doctoral Studies
Education:
Lviv University
Ivan Franko National University of Lviv
Bachelors, Bachelor of Science, Biochemistry University of Massachusetts Amherst
Doctorates, Doctor of Philosophy, Molecular Biology, Biochemistry
Skills:
Biotechnology, Drug Discovery, Lifesciences, Drug Development, Molecular Biology, Genomics, Biochemistry, Commercialization, Clinical Development, Cell Biology, Cancer, Life Sciences, Technology Transfer, Pharmaceutical Industry, Protein Chemistry, Qpcr, R&D, Chemistry, Cell Culture, Dna, Elisa, Science, Assay Development, Pcr, Protein Purification, Cell, Biopharmaceuticals, Immunology, Business Development, Genetics, Strategy, Hplc, Pharmacology, Research and Development, Oncology, Clinical Trials, Microbiology, Biomarker Discovery, Glp, Bioinformatics, Western Blotting, Vaccines, Laboratory, Analytical Chemistry
Languages:
English
Ukrainian
Russian
French
Polish
Dmitry Samarsky Photo 5

Dmitry Samarsky

Location:
Westborough, MA

Publications & IP owners

Us Patents

Tripartite Rnai Constructs

US Patent:
2009013, May 21, 2009
Filed:
Oct 2, 2008
Appl. No.:
12/286896
Inventors:
Tod M. Woolf - Sudbury MA, US
Pamela A. Pavco - Longmont CO, US
William Salomon - Framingham MA, US
Dmitry Samarsky - Westborough MA, US
Nassim Usman - Palo Alto CA, US
Rick Wagner - Cambridge MA, US
International Classification:
A61K 31/7105
C07H 21/02
C07K 2/00
C12N 5/06
C07K 16/18
US Classification:
514 44, 536 245, 530300, 5303911, 435375
Abstract:
The present invention provides compositions and methods for inhibiting expression of a target gene in a cell. The process comprises introduction of double-stranded tripartite RNAi constructs into the cells and reducing the expression of the corresponding messenger RNA in the cells. The constructs, which may be packaged in or delivered as sequestered RNAi constructs, differ from the canonical siRNA in that they comprise a tripartite structure which follows the general formula of having (1) an RNAi core (either native or abbreviated), (2) one or more terminal moieties attached to the RNAi core and optionally (3) a linker between the RNAi core and the terminal moiety. Once packaged into sequestration vehicles, the constructs are activated for gene regulation by the application of certain forms of energy

Neutral Nanotransporters

US Patent:
2011023, Sep 29, 2011
Filed:
Sep 22, 2009
Appl. No.:
13/120341
Inventors:
Anastasia Khvorova - Westborough MA, US
William Salomon - Worcester MA, US
Joanne Kamens - Newton MA, US
Dmitry Samarsky - Westborough MA, US
Tod M. Woolf - Sudbury MA, US
Michelle Miller - Norwood MA, US
Karen G. Bulock - Mendon MA, US
International Classification:
A61K 38/14
A61K 31/7088
A61K 31/713
C12N 5/071
A61P 43/00
US Classification:
514 209, 514 44 R, 514 44 A, 435375
Abstract:
Neutral lipid formulations for nucleic acid delivery are provided according to the invention. The neutral lipid formulations include hydrophobically modified polynucleotides and fat mixtures. Methods of using the neutral lipid formulations are also provided.

Rna Interference In Skin Indications

US Patent:
2011023, Sep 29, 2011
Filed:
Sep 22, 2009
Appl. No.:
13/120315
Inventors:
Anastasia Khvorova - Westborough MA, US
William Salomon - Worcester MA, US
Joanne Kamens - Newton MA, US
Dmitry Samarsky - Westborough MA, US
Tod M. Woolf - Sudbury MA, US
Pamela A. Pavco - Longmont CO, US
Assignee:
RXi Pharmaceuticals Corporation - Worcester MA
International Classification:
A61K 31/713
C07H 21/00
A61P 17/00
A61P 17/02
A61P 11/00
A61P 1/16
A61P 13/12
A61P 21/00
A61P 43/00
A61P 27/02
A61P 9/00
US Classification:
514 44 A, 536 245
Abstract:
The present invention relates to RNAi constructs with improved tissue and cellular uptake characteristics and methods of use of these compounds in dermal applications.

Rnai Constructs And Uses Thereof

US Patent:
2011025, Oct 13, 2011
Filed:
Jul 23, 2009
Appl. No.:
13/055617
Inventors:
Dmitry Samarsky - Westborough MA, US
Tod M. Woolf - Sudbury MA, US
William Solomon - Worcester MA, US
Joanne Kamens - Newton MA, US
Anastasia Khvorova - Northborough MA, US
Pamela A. Pavco - Longmont CO, US
Assignee:
RXi Pharmaceuticals Corporation - Worcester
International Classification:
A61K 31/713
C07H 21/00
US Classification:
514 44 A, 536 245
Abstract:
The invention relates to improved double-stranded RNAi constructs (sometimes referred to as “solo-rxRNA”) and uses thereof. The construct comprises a structure formed in some aspects of the invention by two identical single-stranded polynucleotides, with the structure having two double-stranded stem regions (each having less than 21 base pairs) and a loop or bulge having about 4 to 11 nucleotides on each strand. The construct is resistant to cleavage by Dicer or other Dicer-like RNase III enzymes and is capable of being loaded into a RISC complex to effect RNA interference. In addition, the nucleotides of the present hairpin constructs may be modified to greatly enhance functionality, such as stability and specificity.

Reduced Size Self-Delivering Rnai Compounds

US Patent:
2011026, Oct 27, 2011
Filed:
Mar 23, 2011
Appl. No.:
13/069780
Inventors:
Anastasia Khvorova - Westborough MA, US
William Salomon - Worcester MA, US
Joanne Kamens - Newton MA, US
Dmitry Samarsky - Westborough MA, US
Tod M. Woolf - Sudbury MA, US
James Cardia - Franklin MA, US
Assignee:
RXi Pharmaceuticals Corporation - Worcester MA
International Classification:
A61K 31/713
C12N 5/00
A61P 35/00
A61P 27/02
A61P 29/00
A61P 37/06
A61P 9/00
C07H 21/02
A61P 31/12
US Classification:
514 44 A, 536 245, 435375
Abstract:
The present invention relates to RNAi constructs with minimal double-stranded regions, and their use in gene silencing. RNAi constructs associated with the invention include a double stranded region of 8-14 nucleotides and a variety of chemical modifications, and are highly effective in gene silencing. The RNAi constructs may be, for instance, miRNA constructs that are miRNA modulators.

Phagocytic Cell Delivery Of Rnai

US Patent:
2012001, Jan 19, 2012
Filed:
Jul 17, 2009
Appl. No.:
13/054696
Inventors:
Dmitry Samarsky - Westborough MA, US
Tod M. Woolf - Sudbury MA, US
Assignee:
RXi Pharmaceuticals Corporation - Worcester MA
International Classification:
A61K 31/713
A61P 19/10
A61P 1/00
A61P 19/02
A61P 25/28
A61P 25/00
A61P 31/14
A61P 11/06
C07H 21/02
A61P 31/06
US Classification:
514 44 A, 536 245
Abstract:
The present invention provides a particulate delivery system for delivering an RNAi construct to phagocytic cells such as macrophages, comprising various configurations of a complex comprising a phagocytic cell-targeting moiety and an RNAi construct. The invention further provides methods of making the delivery system, and their uses, such as treating phagocytic cell-associated disease conditions.

Reduced Size Self-Delivering Rnai Compounds

US Patent:
2012004, Feb 16, 2012
Filed:
Sep 22, 2009
Appl. No.:
13/120342
Inventors:
Anastasia Khvorova - Westborough MA, US
William Salomon - Worcester MA, US
Joanne Kamens - Newton MA, US
Dmitry Samarsky - Westborough MA, US
Tod M. Woolf - Sudbury MA, US
James Cardia - Franklin MA, US
Assignee:
RXi Pharmaceuticals Corporation - Worcester MA
International Classification:
C12N 5/071
C12N 15/113
US Classification:
435375, 536 245
Abstract:
The present invention relates to RNAi constructs with minimal double-stranded regions, and their use in gene silencing. RNAi constructs associated with the invention include a double stranded region of 8-14 nucleotides and a variety of chemical modifications, and are highly effective in gene silencing.

Reduced Size Self-Delivering Rnai Compounds

US Patent:
2013013, May 23, 2013
Filed:
Mar 24, 2011
Appl. No.:
13/636728
Inventors:
Anastasia Khvorova - Westborough MA, US
William Salomon - Worcester MA, US
Joanne Kamens - Newton MA, US
Dmitry Samarsky - Westborough MA, US
Tod M. Woolf - Sudbury MA, US
James Cardia - Franklin MA, US
International Classification:
C12N 15/113
US Classification:
514 44 A, 536 245
Abstract:
The present invention relates to methods for in vivo administration of sd-rxRNA molecules.

Isbn (Books And Publications)

Rnai In Drug Discovery And Development

Author:
Dmitry Samarsky
ISBN #:
0849396646

Possible Relatives

Dmitry Tartakovsky  Dmitry M Shapiro  Dmitry E Feldman  Dmitry J Feld  Dmitry Z Gelfand  Dmitry Spektor  Dmitry R Libman  Dmitry A Kovalenko  Dmitry P Gutman  Dmitry R Lubarsky 

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