Dongfang Liu, 54Kirkland, WA
Dongfang Liu Phones & Addresses
Kirkland, WA
3 Johnston Cir, Basking Ridge, NJ 07920 908-6584089
11 Cobble Ct, Unionville, CT 06085 860-4042276
26 Orchid Dr, Plainsboro, NJ 08536 609-2695329 609-7167205
Cambridge, MA
Yorktown Heights, NY
Westborough, MA
Framingham, MA
Dunbar, WV
Mentions for Dongfang Liu
Publications & IP owners
Us Patents
Rationally Designed Heparinases Derived From Heparinase I And Ii
US Patent:
7056504, Jun 6, 2006
Filed:
Aug 27, 1999
Appl. No.:
09/384959
Inventors:
Ram Sasisekharan - Cambridge MA, US
Zachary Shriver - Cambridge MA, US
Dongfang Liu - Framingham MA, US
Ganesh Venkataraman - Woburn MA, US
Zachary Shriver - Cambridge MA, US
Dongfang Liu - Framingham MA, US
Ganesh Venkataraman - Woburn MA, US
Assignee:
Massachusetts Institute of Technology - Cambridge MA
International Classification:
A61K 38/51
C12N 9/88
C07H 21/04
C12N 9/88
C07H 21/04
US Classification:
424 945, 435 2, 435232, 43525233, 4353201, 536 232
Abstract:
Modified heparinases having altered binding specificity and activity are provided. Isolated nucleic acids encoding the same as well as vectors and host cells are provided. Methods for using the modified heparinases are also provided.
Methods And Products Related To The Analysis Of Polysaccarides
US Patent:
7083937, Aug 1, 2006
Filed:
Sep 12, 2001
Appl. No.:
09/951138
Inventors:
Ram Sasisekharan - Lincoln MA, US
Ganesh Venkataraman - Bedford MA, US
Zachary Shriver - Boston MA, US
Dongfang Liu - Westborough MA, US
Mallikarjun Sundaram - Ashland MA, US
Yiwei Qi - Cambridge MA, US
Ganesh Venkataraman - Bedford MA, US
Zachary Shriver - Boston MA, US
Dongfang Liu - Westborough MA, US
Mallikarjun Sundaram - Ashland MA, US
Yiwei Qi - Cambridge MA, US
Assignee:
Massachusetts Institute of Technology - Cambridge MA
International Classification:
C12Q 1/56
US Classification:
435 13, 436 69
Abstract:
The invention relates to methods and products for characterizing and using polysaccharides. Low molecular weight heparin products and methods of use are described. Methods for characterizing purity and activity of polysaccharide preparations including glycosaminoglycans such as heparin are also described.
Methods And Products Related To Evaluating The Quality Of A Polysaccharide
US Patent:
7399604, Jul 15, 2008
Filed:
Jul 15, 2005
Appl. No.:
11/183323
Inventors:
Ram Sasisekharan - Bedford MA, US
Ganesh Venkataraman - Bedford MA, US
Zachary Shriver - Boston MA, US
Dongfang Liu - Yorktown Heights NY, US
Mallikarjun Sundaram - Belmont MA, US
Yiwei Qi - Andover MA, US
Ganesh Venkataraman - Bedford MA, US
Zachary Shriver - Boston MA, US
Dongfang Liu - Yorktown Heights NY, US
Mallikarjun Sundaram - Belmont MA, US
Yiwei Qi - Andover MA, US
Assignee:
Massachusetts Institute of Technology - Cambridge MA
International Classification:
C12Q 1/56
US Classification:
435 13, 514 56, 536 111
Abstract:
The invention relates to methods and products for characterizing and using polysaccharides. Low molecular weight heparin products and methods of use are described. Methods for characterizing purity and activity of polysaccharide preparations including glycosaminoglycans such as heparin are also described.
Rationally Designed Heparinases Derived From Heparinase I And Ii And Methods Of Sequencing Therewith
US Patent:
7560106, Jul 14, 2009
Filed:
Jul 27, 2005
Appl. No.:
11/191144
Inventors:
Ram Sasisekharan - Bedford MA, US
Zachary Shriver - Boston MA, US
Dongfang Liu - Westborough MA, US
Ganesh Venkataraman - Bedford MA, US
Zachary Shriver - Boston MA, US
Dongfang Liu - Westborough MA, US
Ganesh Venkataraman - Bedford MA, US
Assignee:
Massachusetts Institute of Technology - Cambridge MA
International Classification:
A61K 38/00
C12N 9/88
C12N 9/88
US Classification:
424 945, 435 2, 435232, 43525233, 4353201, 536 232
Abstract:
Modified heparinases having altered binding specificity and activity are provided. Isolated nucleic acids encoding the same as well as vectors and host cells are provided. Methods for using the modified heparinases are also provided.
Methods For Evaluating The Quality Of A Heparin Sample
US Patent:
7585642, Sep 8, 2009
Filed:
Nov 30, 2006
Appl. No.:
11/606623
Inventors:
Ram Sasisekharan - Bedford MA, US
Ganesh Venkataraman - Bedford MA, US
Zachary Shriver - Boston MA, US
Dongfang Liu - Westborough MA, US
Mallikarjun Sundaram - Ashland MA, US
Yiwei Qi - Cambridge MA, US
Ganesh Venkataraman - Bedford MA, US
Zachary Shriver - Boston MA, US
Dongfang Liu - Westborough MA, US
Mallikarjun Sundaram - Ashland MA, US
Yiwei Qi - Cambridge MA, US
Assignee:
Massachusetts Institute of Technology - Cambridge MA
International Classification:
C12Q 1/56
US Classification:
435 13, 514 56, 536 111
Abstract:
The invention relates to methods and products for characterizing and using polysaccharides. Low molecular weight heparin products and methods of use are described. Methods for characterizing purity and activity of polysaccharide preparations including glycosaminoglycans such as heparin are also described.
Methods And Producing Low Molecular Weight Heparin
US Patent:
7687479, Mar 30, 2010
Filed:
Sep 8, 2006
Appl. No.:
11/518534
Inventors:
Ram Sasisekharan - Bedford MA, US
Ganesh Venkataraman - Bedford MA, US
Zachary Shriver - Cambridge MA, US
Dongfang Liu - Yorktown Heights NY, US
Mallikarjun Sundaram - Randolph NJ, US
Yiwei Qi - Andover MA, US
Ganesh Venkataraman - Bedford MA, US
Zachary Shriver - Cambridge MA, US
Dongfang Liu - Yorktown Heights NY, US
Mallikarjun Sundaram - Randolph NJ, US
Yiwei Qi - Andover MA, US
Assignee:
Massachusetts Institute of Technology - Cambridge MA
International Classification:
A01N 43/04
US Classification:
514 56
Abstract:
The invention relates, in part, to methods and products related to producing low molecular weight heparin.
Methods And Products Related To Pulmonary Delivery Of Polysaccharides
US Patent:
7709461, May 4, 2010
Filed:
Oct 18, 2001
Appl. No.:
09/982548
Inventors:
Dongfang Liu - Framingham MA, US
Yiwei Qi - Framingham MA, US
Ganesh Venkataraman - Woburn MA, US
Mallikarjun Sundaram - Brighton MA, US
Ram Sasisekharan - Cambridge MA, US
Yiwei Qi - Framingham MA, US
Ganesh Venkataraman - Woburn MA, US
Mallikarjun Sundaram - Brighton MA, US
Ram Sasisekharan - Cambridge MA, US
Assignee:
Massachusetts Institute of Technology - Cambridge MA
International Classification:
A61K 31/715
A01N 43/04
A01N 43/04
US Classification:
514 54, 514 56
Abstract:
The invention relates to methods for delivering polysaccharides by a pulmonary route to achieve local and systemic therapeutic effects. The polysaccharides may be formulated or unformulated and in some instances have an extremely fast absorption rate.
Methods For Analyzing Or Processing A Heparin Sample
US Patent:
8173384, May 8, 2012
Filed:
Jul 27, 2009
Appl. No.:
12/509774
Inventors:
Ram Sasisekharan - Bedford MA, US
Ganesh Venkataraman - Bedford MA, US
Zachary Shriver - Cambridge MA, US
Dongfang Liu - Yorktown Heights NY, US
Mallikarjun Sundaram - Randolph NJ, US
Yiwei Qi - Andover MA, US
Ganesh Venkataraman - Bedford MA, US
Zachary Shriver - Cambridge MA, US
Dongfang Liu - Yorktown Heights NY, US
Mallikarjun Sundaram - Randolph NJ, US
Yiwei Qi - Andover MA, US
Assignee:
Massachusetts Institute of Technology - Cambridge MA
International Classification:
C12Q 1/56
US Classification:
435 13, 514 56, 536 111
Abstract:
The invention relates to methods and products for analyzing or processing a heparin sample. In one embodiment, the methods comprise contacting the sample with heparinase I, heparinase II and heparinase III, determining the amount of a signature component in the sample using a separation method, and making a determination about the sample based upon a comparison of the amount of the signature component in the sample to a reference database for a heparin.
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