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Douglas L Looker, 706449 County Road 21, Wattenburg, CO 80621

Known as:
Douglas Dr Looker Douglas Loren Looker Douglas K Looker Doug Looker Jeanne Looker
Related to:
Carlene E Burnett 58

Douglas Looker Phones & Addresses

6449 County Road 21, Fort Lupton, CO 80621    303-8570199   

Washington Court House, OH   

Longmont, CO   

11189 Flatiron Dr, Lafayette, CO 80026    303-8280126   

Greenwood Village, CO   

Ft Lupton, CO   

Weldona, CO   

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Staffing and Recruiting
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Douglas Looker

Location:
Greater Denver Area
Industry:
Staffing and Recruiting

Publications & IP owners

Us Patents

Reduced Side-Effect Hemoglobin Compositions

US Patent:
6670323, Dec 30, 2003
Filed:
Nov 10, 2000
Appl. No.:
09/709914
Inventors:
Douglas L. Looker - Lafayette CO
Izydor Z. Apostol - Boulder CO
Eric A. Brucker - Evergreen CO
Michael P. Doyle - Boulder CO
David L. Foster - Lafayette CO
Christopher B. Glascock - Louisville CO
James C. Hartman - Boulder CO
Geoffrey F. Lee - Boulder CO
Douglas D. Lemon - Louisville CO
Edwin G. Moore - Boulder CO
Jane P. Richards - Longmont CO
Michael R. Schick - Louisville CO
Stephen P. Trimble - Boulder CO
David Pereira - Apex NC
Ton-That Hai - Mundelein IL
Kenneth E. Burhop - Longmont CO
Assignee:
Baxter International, Inc. - Deerfield IL
Baxter Healthcare S.A. - Kanton Zurich
International Classification:
C07K 14805
US Classification:
514 6, 535385
Abstract:
The invention relates to novel hemoglobin compositions, particularly novel recombinant mutant hemoglobin compositions, which eliminate or substantially reduce 1) the creation of heart lesions, 2) gastrointestinal discomfort, 3) pressor effects, and 4) endotoxin hypersensitivity associated with the administration of extracellular hemoglobin compositions in various therapeutic applications. Applications described include treatments for anemia, head injury, hemorrhage or hypovolemia, ischemia, cachexia, sickle cell crisis and stroke; enhancing cancer treatments; stimulating hematopoiesis; improving repair of physically damaged tissues; alleviating cardiogenic shock; and shock resuscitation.

Dna Encoding Fused Di-Alpha Globins And Use Thereof

US Patent:
6828125, Dec 7, 2004
Filed:
May 30, 1995
Appl. No.:
08/453485
Inventors:
Stephen J. Hoffman - Denver CO
Douglas L. Looker - Lafayette CO
Kiyoshi Nagai - Cambridge, GB
Assignee:
Baxter Biotech Technology, S.a.r.l. - Neuchatel
International Classification:
C12P 2106
US Classification:
435 696, 435 691, 4353201, 536 231, 530385
Abstract:
The alpha subunits of hemoglobin, which in nature are formed as separate polypeptide chains which bind noncovalently to the beta subunits, are here provided in the form of the novel molecule di-alpha globin, a single polypeptide chain defined by connecting the two alpha subunits either directly via peptide bond or indirectly by a flexible amino acid or peptide linker. Di-alpha globin may be combined in vivo or in vitro with beta globin and heme to form hemoglobin. Di-alpha globin is expressed by recombinant DNA techniques. Di-beta globin may be similarly obtained.

Reduced Side-Effect Hemoglobin Compositions

US Patent:
7211560, May 1, 2007
Filed:
Dec 29, 2003
Appl. No.:
10/747580
Inventors:
Douglas L. Looker - Fort Lupton CO, US
Izydor Z. Apostol - Boulder CO, US
Eric A. Brucker - Evergreen CO, US
Michael P. Doyle - Boulder CO, US
David L. Foster - Lafayette CO, US
Christopher B. Glascock - Louisville CO, US
James C. Hartman - Boulder CO, US
Geoffrey F. Lee - Boulder CO, US
Douglas D. Lemon - Louisville CO, US
Edwin G. Moore - Boulder CO, US
Jane P. Richards - Longmont CO, US
Michael R. Schick - Louisville CO, US
Stephen P. Trimble - Boulder CO, US
David Pereira - Apex NC, US
Ton-That Hai - Mundelein IL, US
Kenneth E. Burhop - Longmont CO, US
Assignee:
Baxter International, Inc. - Deerfield IL
Baxter Healthcare S.A. - Zurich
International Classification:
A61K 35/14
US Classification:
514 6, 530385
Abstract:
The invention relates to novel hemoglobin compositions, particularly novel recombinant mutant hemoglobin compositions, which eliminate or substantially reduce 1) the creation of heart lesions, 2) gastrointestinal discomfort, 3) pressor effects, and 4) endotoxin hypersensitivity associated with the administration of extracellular hemoglobin compositions in various therapeutic applications. Applications described include treatments for anemia, head injury, hemorrhage or hypovolemia, ischemia, cachexia, sickle cell crisis and stroke; enhancing cancer treatments; stimulating hematopoiesis; improving repair of physically damaged tissues; alleviating cardiogenic shock; and shock resuscitation.

Dna Encoding Fused Di-Alpha Globins And Production Of Pseudotetrameric Hemoglobin

US Patent:
5545727, Aug 13, 1996
Filed:
Nov 8, 1991
Appl. No.:
7/789179
Inventors:
Stephen J. Hoffman - Denver
Douglas L. Looker - Lafayette CO
Kiyoshi Nagai - Cambridge, GB2
Assignee:
Somatogen, Inc. - Boulder CO
International Classification:
C12N 1512
C07K 14805
US Classification:
536234
Abstract:
The alpha subunits of hemoglobin, which in nature are formed as separate polypeptide chains which bind noncovalently to the beta subunits, are here provided in the form of the novel molecule di-alpha globin, a single polypeptide chain defined by connecting the two alpha subunits either directly via peptide bond or indirectly by a flexible amino acid or peptide linker. Di-alpha globin may be combined in vivo or in vitro with beta globin and heme to form hemoglobin. Di-alpha globin is expressed by recombinant DNA techniques. Di-beta globin may be similarly obtained. DNA encoding alpha globin fusion proteins is provided.

Storage Stable Hemoglobin Solutions

US Patent:
5929031, Jul 27, 1999
Filed:
May 2, 1995
Appl. No.:
8/433896
Inventors:
Bruce A. Kerwin - Lafayette CO
Douglas L. Looker - Lafayette CO
Assignee:
Baxter Biotech Technology Sarl - Neuchatel
International Classification:
A61K 3816
A61K 3514
C07K 100
US Classification:
514 12
Abstract:
The present invention relates to storage stable hemoglobin solutions which contain partially deoxygenated and surprisingly low amounts of reducing agents. Methods for preparing such storage stable hemoglobin solutions are also provided as well as a systems for storing the solutions.

Stabilized Compositions Containing Hemoglobin

US Patent:
6242417, Jun 5, 2001
Filed:
Apr 5, 1995
Appl. No.:
8/417644
Inventors:
Michael J. Gerber - Denver CO
Douglas L. Looker - Lafayette CO
Bruce A. Kerwin - Lafayette CO
Assignee:
Somatogen, Inc. - Boulder CO
International Classification:
A61K 3816
A01N 102
G01N 3372
G01N 3100
US Classification:
514 6
Abstract:
The present invention relates to a hemoglobin compositions stabilized against the formation of aggregates. The present invention further relates to methods of making such hemoglobin compositions.

Method Of Determining A Functional Linker For Fusing Globin Subunts

US Patent:
6274331, Aug 14, 2001
Filed:
May 19, 1995
Appl. No.:
8/444915
Inventors:
Douglas L. Looker - Lafayette CO
Gary L. Stetler - Denver CO
Assignee:
Somatogen, Inc. - Boulder CO
International Classification:
G01N 3353
US Classification:
435 72
Abstract:
A functional linker for a polypeptide in which two alpha or beta globin-like domains are genetically fused is determined by screening a library of genetically fused polypeptides, in which the linker region is varied, for the ability to participate in the formation of hemoglobin-like protein, as measured by the protein's response to carbon monoxide. In a preferred embodiment, cells expressing the protein turn red as a result of carbon monoxide pressure.

Genetically Fused Globin-Like Polypeptides Having Hemoglobin-Like Activity

US Patent:
5844089, Dec 1, 1998
Filed:
May 25, 1995
Appl. No.:
8/450733
Inventors:
Stephen J. Hoffman - Denver CO
Douglas L. Looker - Lafayette CO
Mary S. Rosendahl - Broomfield CO
Gary L. Stetler - Denver CO
Michael Wagenbach - Osaka, JP
David C. Anderson - Lafayette CO
Antony James Mathews - Louisville CO
Kiyoshi Nagai - Cambridge, GB2
Assignee:
Somatogen, Inc. - Boulder CO
International Classification:
C07K 14805
US Classification:
530385
Abstract:
The alpha subunits of hemoglobin, which in nature are formed as separate polypeptide chains which bind noncovalently to the beta subunits, are here provided in the form of the novel molecule di-alpha globin, a single polypeptide chain defined by connecting the two alpha subunits either directly via peptide bond or indirectly by a flexible amino acid or peptide linker. Di-alpha globin may be combined in vivo or in vitro with beta globin and heme to form hemoglobin. Di-alpha globin is expressed by recombinant DNA techniques. Di-beta globin may be similarly obtained.

Possible Relatives

David G Looker  Dennis W Looker  George H Looker  Hazel F Looker  Hugh E Looker  James A Looker  Joseph C Looker  Douglas P Johnson  Douglas R Stamps  Douglas J Standish 

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