Inventors:
Douglas L. Looker - Fort Lupton CO, US
Izydor Z. Apostol - Boulder CO, US
Eric A. Brucker - Evergreen CO, US
Michael P. Doyle - Boulder CO, US
David L. Foster - Lafayette CO, US
Christopher B. Glascock - Louisville CO, US
James C. Hartman - Boulder CO, US
Geoffrey F. Lee - Boulder CO, US
Douglas D. Lemon - Louisville CO, US
Edwin G. Moore - Boulder CO, US
Jane P. Richards - Longmont CO, US
Michael R. Schick - Louisville CO, US
Stephen P. Trimble - Boulder CO, US
David Pereira - Apex NC, US
Ton-That Hai - Mundelein IL, US
Kenneth E. Burhop - Longmont CO, US
Assignee:
Baxter International, Inc. - Deerfield IL
Baxter Healthcare S.A. - Zurich
International Classification:
A61K 35/14
Abstract:
The invention relates to novel hemoglobin compositions, particularly novel recombinant mutant hemoglobin compositions, which eliminate or substantially reduce 1) the creation of heart lesions, 2) gastrointestinal discomfort, 3) pressor effects, and 4) endotoxin hypersensitivity associated with the administration of extracellular hemoglobin compositions in various therapeutic applications. Applications described include treatments for anemia, head injury, hemorrhage or hypovolemia, ischemia, cachexia, sickle cell crisis and stroke; enhancing cancer treatments; stimulating hematopoiesis; improving repair of physically damaged tissues; alleviating cardiogenic shock; and shock resuscitation.