Duncan A Smith, 65San Juan Island, WA

6977264, Dec 20, 2005

Jul 24, 2002

10/205649

Christopher H. Fotsch - Thousand Oaks CA, US
Michael Croghan - Thousand Oaks CA, US
Elizabeth M. Doherty - Newbury Park CA, US
Michael G. Kelly - South San Francisco CA, US
Mark H. Norman - Thousand Oaks CA, US
Duncan M. Smith - Thousand Oaks CA, US
Nuria Tamayo - Newbury Park CA, US
Ning Xi - Thousand Oaks CA, US
Shimin Xu - Ventura CA, US

Amgen Inc. - Thousand Oaks CA

C07D211/06
A61K031/445

514330, 546226

Selected substituted piperidine compounds are effective for prophylaxis and treatment of diseases, such as obesity and the like. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving activation of the melanocortin receptor. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

7115607, Oct 3, 2006

Jul 24, 2002

10/202823

Christopher H. Fotsch - Thousand Oaks CA, US
Premilla Arasasingham - Thousand Oaks CA, US
Yunxin Bo - Thousand Oaks CA, US
Ning Chen - Thousand Oaks CA, US
Martin H. Goldberg - Woodland Hills CA, US
Nianhe Han - Thousand Oaks CA, US
Feng-Yin Hsieh - Thousand Oaks CA, US
Michael G. Kelly - Thousand Oaks CA, US
Qingyian Liu - Camarillo CA, US
Mark H. Norman - Thousand Oaks CA, US
Duncan M. Smith - Thousand Oaks CA, US
Markian Stec - Fillmore CA, US
Nuria Tamayo - Newbury Park CA, US
Ning Xi - Thousand Oaks CA, US
Shimin Xu - Moorpark CA, US

Amgen Inc. - Thousand Oaks CA

A61K 31/496
C07D 401/12
C07D 403/12

51425213, 51425305, 51425306, 51425313, 51425409, 544359, 544363, 544365, 544373, 544376, 544379

Selected substituted piperazine compounds of Formula I are effective for prophylaxis and treatment of diseases, such as obesity and the like. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving activation of the melanocortin receptor. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

2007026, Nov 15, 2007

Apr 27, 2005

11/116759

Christopher Fotsch - Thousand Oaks CA, US
Premilla Arasasingham - Thousand Oaks CA, US
Yunxin Bo - Thousand Oaks CA, US
Ning Chen - Thousand Oaks CA, US
Martin Goldberg - Woodland Hills CA, US
Nianhe Han - Thousand Oaks CA, US
Feng-Yin Hsieh - Thousand Oaks CA, US
Michael Kelly - South San Francisco CA, US
Qingyian Liu - Camarillo CA, US
Mark Norman - Thousand Oaks CA, US
Duncan Smith - Thousand Oaks CA, US
Markian Stec - Fillmore CA, US
Nuria Tamayo - Newbury Park CA, US
Ning Xi - Thousand Oaks CA, US
Shimin Xu - Santa Barbara CA, US
Elizabeth Doherty - Newbury Park CA, US

Amgen Inc. - Thousand Oaks CA

A61K 31/4965
A61K 31/497
A61K 31/551
A61P 3/10
C07D 243/08
C07D 401/00
C07D 403/12
C07D 407/00

514218000, 514252130, 514253010, 514253060, 514254050, 514254090, 514254110, 514255010, 540575000, 544359000, 544360000, 544363000, 544370000, 544373000, 544377000, 544386000

Selected substituted piperazine compounds are effective for prophylaxis and treatment of diseases, such as obesity and the like. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving activation of the melanocortin receptor. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

5541565, Jul 30, 1996

May 22, 1995

8/445965

John E. Dowsing - Redondo Beach CA
Jeffrey M. Edwards - Hollywood CA
Duncan M. Smith - Torrance CA

TRW Inc. - Redondo Beach CA

H01P 502
H01L 23495

333 34

An enclosure assembly for a high frequency integrated circuit. The enclosure assembly includes a plurality of lead terminals that are part of a lead frame. The lead terminals are connected to electrical ports of the circuit within the enclosure to connect the circuit to other integrated circuits and/or to a printed circuit board. A portion of the lead terminals outside of the enclosure has a specially shaped flared region that establishes the characteristic impedance of the circuit on the lead lines outside of the enclosure.

5231361, Jul 27, 1993

Feb 5, 1990

7/474909

Duncan M. Smith - Redondo Beach CA
Barry R. Allen - Redondo Beach CA

TRW Inc. - Redondo Beach CA

H03B 512
H03B 518

331 56

The present invention resides in a push-push voltage controlled oscillator (VCO) utilizing parallel LC resonant tank circuits for improved phase noise characteristics. The push-push VCO of the present invention includes two voltage controlled oscillators connected in parallel and in phase opposition, with each oscillator including a transistor connected in series with the parallel LC resonant tank circuit. The oscillators operate at the same resonant frequency f. sub. 0, but are 180 degrees out of phase. Therefore, the fundamental and odd harmonics of the resonant frequency f. sub. 0 cancel each other out and the even harmonics add together to produce an output signal at twice the resonant frequency f. sub.

6072371, Jun 6, 2000

Jun 16, 1997

8/876275

Kevin W. Kobayashi - Torrance CA
Duncan M. Smith - Torrance CA
Aaron K. Oki - Torrance CA
Arvind K. Sharma - Torrance CA
Barry R. Allen - Redondo Beach CA

TRW Inc. - Redondo Beach CA

H03B 500
H03B 512

331 49

A quenchable VCO that is adapted to be used in switched band synthesizer applications. The VCO may be formed from a heterojunction bipolar transistor (HBT) in a common collector configuration. A quenching circuit which includes a p-i-n diode, is electrically coupled in series with the collector of the HBT. The p-i-n diode is adapted to be monolithically integrated with the HBT. Since the p-i-n diode is electrically connected to the collector of the HBT, as opposed to the base and emitter terminals of the HBT, which forms the main oscillator feedback loop, the Q-factor of the p-i-n diode will have relatively less loading on the phase noise of the HBT oscillator. Moreover, since the p-i-n diode is isolated from the base-emitter junction, the configuration will result in reduced frequency pulling and generation of spurious oscillation and transient effects due to the switching of the p-i-n diode quenched circuit. The use of a p-i-n diode for quenching of VCO also provides other inherent advantages over other types of semi-conductor switches, such as FET, Schottky diodes, PN diodes for quenchable VCO applications because p-i-n diodes are relative insensitive to RF and noise modulation. Because the p-i-n diode can be constructed from existing HBT collector-base MBE epitaxy layers, the quenching circuit can be manufactured relatively inexpensively.

5995818, Nov 30, 1999

Jul 30, 1996

8/688596

Duncan M. Smith - Torrance CA

TRW Inc. - Redondo Beach CA

H04B 110

455302

A small elliptic high pass filter is incorporated into a low noise block downconverter (LNB) to reject image frequencies in a 12 GHz Direct home satellite television Broadcasting System (DBS). A waveguide transition with separate electric probes receives Ku-band satellite signals and transmits the signals to low noise amplifiers (LNAs), a power combiner, an elliptic high pass filter, and a HEMT MMIC receiver. Within the HEMT MMIC receiver, the signal is passed through an RF amplifier stage. A mixer mixes the signal from the RF amplifier stage with a local oscillator signal to produce an intermediate frequency (IF). An IF amplifier stage amplifies the IF signal which is further processed by a television decoder box. Due to the unique response of the elliptic high pass filter, the elliptic high pass filter provides a superior image rejection with lower insertion loss for the LNB, and therefore provides improved television reception quality.