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Dwight R Stoll, 73Albany, OR

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Albany, OR   

Albuquerque, NM   

11077 Nokay Lake Rd NE, Brainerd, MN 56401   

16035 Nokay Lake Rd, Brainerd, MN 56401   

Minneapolis, MN   

Fallbrook, CA   

Stanley, NM   

Santa Fe, NM   

Carlsbad, CA   

Ramah, NM   

Hemphill, TX   

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Us Patents

Chelator-Modified Inorganic Oxide Particles

US Patent:
8137548, Mar 20, 2012
Filed:
Oct 14, 2004
Appl. No.:
10/965273
Inventors:
Clayton McNeff - Anoka MN, US
Bingwen Yan - Shoreview MN, US
Dwight Stoll - Anoka MN, US
Assignee:
Zirchrom Separations, Inc. - Anoka MN
International Classification:
B01D 15/08
US Classification:
2101982, 2105021, 210635, 210656, 502402
Abstract:
The present invention is directed to inorganic oxide particles that have been modified with a chelator group. In an embodiment, the chelator group is covalently bonded to a polymer. In an embodiment, the chelator group is covalently bonded to a chiral selector ligand. The present invention is also directed to methods of modifying inorganic oxide particles with a chelator group.

High Stability Porous Metal Oxide Spherules Used For One-Step Antibody Purifications

US Patent:
2004000, Jan 15, 2004
Filed:
May 2, 2003
Appl. No.:
10/428231
Inventors:
Clayton McNeff - Anoka MN, US
Peter Carr - St. Paul MN, US
Steven Rupp - Minnetonka MN, US
Dwight Stoll - Anoka MN, US
Danielle Hawker - Shakopee MN, US
Lorinda Zigan - Browerville MN, US
Kerry Johnson - Minneapolis MN, US
International Classification:
B01D015/08
US Classification:
210/656000, 210/198200, 530/413000, 530/417000
Abstract:
The present invention describes the use of porous metal oxides for the preparative purification of antibodies and biomolecules within a range of particle physical characteristics. Typically, particles from 15 to 100 microns in average diameter with pores sizes ranging from 400 to 600 angstroms and surface areas from 10 to 50 square meters per gram, and pore volumes from 0.1 to 0.4 mL/gram can be used for purification processes. The metal oxide particles that fall within this range of physical properties show enhanced utility and greater chromatographic capacity for antibodies than materials oxide particles falling outside of this range. Metal oxides such as zirconia, titania and alumina can all be modified with a multi-Lewis base moiety such as an organophosphate ethylenediamine-N,N-tetra(methylenephosphonic) acid (EDTPA), to produce a bio-compatible purification media for, biomolecules.

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