Edward T Joseph, 78Houlton, WI

6482223, Nov 19, 2002

Jun 1, 2000

09/585488

Karol L. Nowakowski - Circle Pines MN
James E. Olson - Eagan MN
Edward T. Joseph - Inver Grove Heights MN
Daniel G. Ericson - Rochester MN

Closys Corporation - Edina MN

A61B 1704

606213, 424530, 210782, 210651, 422 44

Wound closure methods and apparatus are provided which utilize blood fluid by activating the clotting cascade of blood fluid outside the body within a substantially enclosed sterile container then introducing the blood fluid to the wound site to complete clotting. Methods and apparatus for providing ways of inhibiting anti-coagulating agents and slowing fibrin clot degradation are also disclosed. Kits for practicing the invention singularly or in combination with and/or associated with preferred procedures are also disclosed. The present invention provides improved methods of creating hemostasis or control of bleeding at the site of wounds, particularly wounds created in arteries during procedures employing percutaneous access. The invention preferably includes the steps of acquiring an aliquot of a patients blood, i. e. , autologous blood, removing a negatively charged anti-coagulating agent, preferably heparin, from the blood, and preferably initiating the bloods natural clotting cascades and transporting the thus treated blood to the site of the wound where the clotting cascade will be completed producing a clot at the wound site that will create a condition of hemostasis.

8343084, Jan 1, 2013

Oct 29, 2010

12/915822

Karol L. Nowakowski - Circle Pines MN, US
James E. Olson - Eagan MN, US
Edward T. Joseph - Inver Grove Heights MN, US
Daniel G. Ericson - Rochester MN, US

Closys Corporation - St. Paul MN

A61M 37/00
A61M 31/00
A61B 19/00
A61K 31/74
A61K 47/48

604 401, 604 501, 604 607, 604 609, 604 612, 604 615, 604 616, 604522, 604403, 424 7808, 424 7809, 424 781, 424 7817, 424 7826

A wound closure apparatus and associated methods are provided which utilize blood fluid by activating the clotting cascade of blood fluid within a substantially enclosed sterile container then introducing the blood fluid to the wound site to complete clotting. An apparatus for providing ways of inhibiting anticoagulating agents and slowing fibrin clot degradation are also disclosed. Kits are also disclosed. The invention provides a clotting cascade initiation apparatus including a substantially enclosed sterile containment chamber within which an aliquot of blood fluid, either autologous or from donor sources, can be received and retained. In preferred embodiments, the sterile containment chamber further includes a heparin binding agent which will bind heparin and remove it from the blood fluid. In further embodiments, the containment chamber will also include a procoagulating agent, wherein a clotting cascade can be initiated when the blood fluid is accepted into the sterile containment chamber.

2003006, Apr 10, 2003

Nov 12, 2002

10/291965

Karol Nowakowski - Circle Pines MN, US
James Olson - Eagan MN, US
Edward Joseph - Inver Grove Heights MN, US
Daniel Ericson - Rochester MN, US

Closys Corporation

A61B017/08

606/214000

Wound closure methods and apparatus are provided which utilize blood fluid by activating the clotting cascade of blood fluid outside the body within a substantially enclosed sterile container then introducing the blood fluid to the wound site to complete clotting. Methods and apparatus for providing ways of inhibiting anti-coagulating agents and slowing fibrin clot degradation are also disclosed. Kits for practicing the invention singularly or in combination with and/or associated with preferred procedures are also disclosed. The present invention provides improved methods of creating hemostasis or control of bleeding at the site of wounds, particularly wounds created in arteries during procedures employing percutaneous access. The invention preferably includes the steps of acquiring an aliquot of a patient's blood, i.e., autologous blood, removing a negatively charged anti-coagulating agent, preferably heparin, from the blood, and preferably initiating the blood's natural clotting cascades and transporting the thus treated blood to the site of the wound where the clotting cascade will be completed producing a clot at the wound site that will create a condition of hemostasis. The invention further provides a clotting cascade initiation apparatus including a substantially enclosed sterile containment chamber within which an aliquot of blood fluid, either autologous or from donor sources, can be received and retained. In preferred embodiments, the sterile containment chamber further includes a heparin binding agent which will bind heparin and remove it from the blood fluid. In further embodiments the containment chamber will also include a procoagulating agent, wherein a clotting cascade can be initiated when the blood fluid is accepted into the sterile containment chamber.

6015419, Jan 18, 2000

Aug 31, 1998

9/143833

Scott E. Strome - Rochester MN
Edward T. Joseph - Inver Grove Heights MN

Strome Steel Surgical, Inc. - Ann Arbor MI

A61B 1732

606167

A surgical instrument includes a hollow handle having an end slot and a side slot and a blade carrier securable to a scalpel blade and moveable between first and second positions relative to the handle. One of the first and second positions is an extended, in-use position wherein the scalpel blade extends out of the handle through the end slot. The other position is a retracted, non-use position wherein the scalpel blade is wholly disposed within the handle. At least one finger extends from the blade carrier and has a first contoured portion engageable, when the blade carrier is in the first position, with a second contoured portion of the handle. The first and second contoured portions are substantially complementary such that the finger must deflect to permit disengagement of the first contoured portion of the finger from the second contoured portion of the handle so that the blade carrier can be moved from the first position toward the second position. A locking cam is moveable between a locked position wherein the locking cam substantially inhibits deflection of the finger of the blade carrier and an unlocked position wherein the locking cam permits deflection of the finger of the blade carrier. A method of using this surgical instrument includes the steps of moving the locking cam to the unlocked position if the locking cam is in the locked position, moving the blade carrier from the first position to the second position or from the second position to the first position, and moving the locking cam to the locked position.